Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches?

Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches?

Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and cartilage formation and then discovered that this factor mediates several physiologic functions and hemostasis. Besides physiological condition...

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Bibliographic Details
Published in:Journal of drug targeting Vol. 31; no. 7; pp. 714 - 724
Main Authors: Alkhathami, Ali G., Abdullah, Mustafa Ryadh, Ahmed, Muhjaha, Hassan Ahmed, Hanan, Alwash, Sarab W., Muhammed Mahdi, Zahra, Alsaikhan, Fahad, Dera, Ayed A.
Format: Journal Article
Language:English
Published: England Taylor & Francis 09-08-2023
Subjects:
BMP9
cancer
cancer targeting
GDF2
SMADs
solid tumour
TGFβ
tumour targeting
cancer targeting
tumor targeting
SMADs
GDF2
TGFβ
solid tumor
BMP9
Cancer
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Summary:Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and cartilage formation and then discovered that this factor mediates several physiologic functions and hemostasis. Besides physiological conditions, BMP9 has also been elucidated that it is involved in several pathological situations, especially cancer. In various cancers, dysregulation of BMP9 has raised the issue that BMP9 might play a conflicting role in tumour development. BMP9 binding to its receptors (BMPRs), including ALKs and BMPRII, induces canonical SMAD-dependent and non-canonical PI3K/AKT and MAPK signalling pathways in tumour cells. BMP9, via inducing apoptosis, inhibiting tumour-promoting cell signalling pathways, suppressing epithelial-mesenchymal transition (EMT) process, blocking angiogenesis, and preventing cross-talk in the tumour microenvironment, mainly exerts tumour-suppressive functions. In contrast, BMP9 triggers tumour-supportive signalling pathways, promotes EMT, and enhances angiogenesis, suggesting that BMP9 is also involved in tumour development. It has been demonstrated that modulating BMP9 expression and functions might be a promising approach to cancer treatment. It has also been indicated that evaluating BMP9 expression in cancers might be a biomarker for predicting cancer prognosis. Overall, BMP9 would provide a promising target in cancer management.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2023.2236330