Search Results - "Abdulla, Maha Hamadien"

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells by El-Wetidy, Mohammad S., Ahmad, Rehan, Rady, Islam, Helal, Hamed, Rady, Mohamad I., Vaali-Mohammed, Mansoor-Ali, Al-Khayal, Khayal, Traiki, Thamer Bin, Abdulla, Maha-Hamadien

“…Colorectal cancer (CRC) is the second most common gastrointestinal cancer globally. Prevention of tumor cell proliferation and metastasis is vital for…”
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Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer by Eldehna, Wagdy M., Salem, Rofaida, Elsayed, Zainab M., Al-Warhi, Tarfah, Knany, Hamada R., Ayyad, Rezk R., Traiki, Thamer Bin, Abdulla, Maha-Hamadien, Ahmad, Rehan, Abdel-Aziz, Hatem A., El-Haggar, Radwan

“…In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a-e and 7a-i) was designed and synthesised. The anticancer activity for…”
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The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer by Abdulla, Maha-Hamadien, Alzailai, Aminah Ahmad, Vaali-Mohammed, Mansoor-Ali, Ahmad, Rehan, Fatima, Sabiha, Zubaidi, Ahmed, Traiki, Thamer bin, Mahmood, Amer, Hamoud Alrashoudi, Reem, Khan, Zahid

“…Introduction: There is a steady increase in colorectal cancer (CRC) incidences worldwide; at diagnosis, about 20 percent of cases show metastases. The…”
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Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor by Abdulla, Maha-Hamadien, Lim, Kee-Chong, Sajid, Mohammed, McKerrow, James H, Caffrey, Conor R

“…Schistosomiasis is a chronic, debilitating parasitic disease infecting more than 200 million people and is second only to malaria in terms of public health…”
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Herbal melanin inhibits colorectal cancer cell proliferation by altering redox balance, inducing apoptosis, and modulating MAPK signaling by Al-Obeed, Omar, El-Obeid, Adila Salih, Matou-Nasri, Sabine, Vaali-Mohammed, Mansoor-Ali, AlHaidan, Yazeid, Elwatidy, Mohammed, Al Dosary, Hamad, Alehaideb, Zeyad, Alkhayal, Khayal, Haseeb, Adil, McKerrow, James, Ahmad, Rehan, Abdulla, Maha-Hamadien

“…Colorectal carcinoma is one of the most deadly cancers that requests effective and safe chemotherapy. Evaluation of natural product-based anticancer drugs as…”
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Bursatella leachii Purple Ink Secretion Concentrate Exerts Cytotoxic Properties against Human Hepatocarcinoma Cell Line (HepG2): In Vitro and In Silico Studies by Alehaideb, Zeyad I, Venkatraman, Anuradha, Kokane, Mahadev, Mohamed, Syed Ali, Rameshbabu, Saranya, Suliman, Rasha S, Alghamdi, Sahar S, Al-Eidi, Hamad, Alghanem, Bandar, Abdulla, Maha-Hamadien, Matou-Nasri, Sabine

“…Liver cancer is a leading cause of cancer death globally. Marine mollusc-derived drugs have gained attention as potential natural-based anti-cancer agents to…”
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Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population by Alkhayal, Khayal A, Awadalia, Zainab H, Vaali-Mohammed, Mansoor-Ali, Al Obeed, Omar A, Al Wesaimer, Alanoud, Halwani, Rabih, Zubaidi, Ahmed M, Khan, Zahid, Abdulla, Maha-Hamadien

“…Vitamin D, causally implicated in bone diseases and human malignancies, exerts its effects through binding to the vitamin D receptor (VDR). VDR is a…”
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Evidence of Association between CTLA-4 Gene Polymorphisms and Colorectal Cancers in Saudi Patients by Al-Harbi, Nouf, Abdulla, Maha-Hamadien, Vaali-Mohammed, Mansoor-Ali, Bin Traiki, Thamer, Alswayyed, Mohammed, Al-Obeed, Omar, Abid, Islem, Al-Omar, Suliman, Mansour, Lamjed

“…Cytotoxic T lymphocyte antigen-4 (CTLA-4) has been identified as an immunosuppressive molecule involved in the negative regulation of T cells. It is highly…”
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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening by Abdulla, Maha-Hamadien, Ruelas, Debbie S, Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R, Williams, Janice, McKerrow, James H, Caffrey, Conor R

“…Praziquantel (PZQ) is the only widely available drug to treat schistosomiasis. Given the potential for drug resistance, it is prudent to search for novel…”
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5-year oncological outcomes in left-sided malignant colonic obstruction: stent as bridge to surgery by Alhassan, Noura S, AlShammari, Sulaiman A, AlRabah, Razan N, AlZahrani, Amirah M, Abdulla, Maha-Hamadien, Traiki, Thamer A Bin, Zubaidi, Ahmad M, Al-Obeed, Omar A, Alkhayal, Khayal A

“…A considerable number of patients with colon cancer present with a colonic obstruction. The use of self-expanding metallic stents (SEMS) as a bridge to surgery…”
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Oncological outcomes of elective versus emergency surgery for colon cancer: A tertiary academic center experience by Bin Traiki, Thamer A, AlShammari, Sulaiman A, AlRabah, Razan N, AlZahrani, Amirah M, Alshenaifi, Saud T, Alhassan, Noura S, Abdulla, Maha-Hamadien, Zubaidi, Ahmad M, Al-Obeed, Omar A, Alkhayal, Khayal A

“…In this study, we aimed to identify the oncological outcomes in colon cancer patients who underwent elective versus emergency curative resection. All patients…”
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The Anticancer Effects of the Pro-Apoptotic Benzofuran-Isatin Conjugate (5a) Are Associated With p53 Upregulation and Enhancement of Conventional Chemotherapeutic Drug Efficiency in Colorectal Cancer Cell Lines by Vaali-Mohammed, Mansoor-Ali, Abdulla, Maha-Hamadien, Matou-Nasri, Sabine, Eldehna, Wagdy M., Meeramaideen, M., Elkaeed, Eslam B., El-Watidy, Mohammed, Alhassan, Noura S., Alkhaya, Khayal, Al Obeed, Omar

“…The present study aimed to investigate in-depth a cytotoxic novel benzofuran-isatin conjugate (5a,…”
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The impact of preoperative total parenteral nutrition on the surgical complications of Crohn's disease: A retrospective cohort study by Traiki, Thamer, Alshammari, Sulaiman, Aljomah, Nadia, Alsalouli, Monirah, Altawil, Esraa, Abdulla, Maha-Hamadien, Alhassan, Noura, Alkhayal, Khayal

“…Background: Crohn's disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients,…”
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Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs by Abdulla, Maha-Hamadien, Lim, Kee-Chong, McKerrow, James H, Caffrey, Conor R

“…Eggs deposited in the liver of the mammalian host by the blood fluke parasite, Schistosoma mansoni, normally drive a T-helper-2 (Th2)-mediated granulomatous…”
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RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model by Abdulla, Maha-Hamadien, O'Brien, Theresa, Mackey, Zachary B, Sajid, Mohamed, Grab, Dennis J, McKerrow, James H

“…We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an…”
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Anti-Proliferative and Pro-Apoptotic Effects of Calligonum comosum (L’Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells by Alehaideb, Zeyad, AlGhamdi, Saleh, Yahya, Wesam Bin, Al-Eidi, Hamad, Alharbi, Mashael, Alaujan, Monira, Albaz, Abeer, Tukruni, Muruj, Nehdi, Atef, Abdulla, Maha-Hamadien, Matou-Nasri, Sabine

“…Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an…”
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Prevalence of vasovagal syncope following bariatric surgery by Al Obeed, Omar, Traiki, Thamer, Alfahad, Yara, Abdulla, Maha-Hamadien, AlAli, Mohamed, Alharbi, Abdulhamed, Alharbi, Reem, Nouh, Thamer, Hersi, Ahmad

“…Background: Obesity is a major global public health problem. Observational studies have shown an increasing incidence of syncope and pre-syncope following…”
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TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection by Abdulla, Maha-Hamadien, Bakhiet, Moiz, Lejon, Veerle, Andersson, Jan, McKerrow, James, Al-Obeed, Omar, Harris, Robert A

“…Trypanosome-derived lymphocyte triggering factor (TLTF) is a molecule released by African trypanosomes that interacts with the host immune system, resulting in…”
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Lymphangioma of the ileocecal valve clinically masquerading as a submucosal small intestinal GIST: report of a case and literature review by Al-Obeed, Omar A, Abdulla, Maha-Hamadien

“…Lymphangiomas are rare tumors affecting the gastrointestinal tract, and may be seen in the bowel, gall bladder, and pancreas. They resemble hemangiomas, but…”
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Association of the microbiome with colorectal cancer development (Review) by Abdulla, Maha-Hamadien, Agarwal, Disha, Singh, Jaikee Kumar, Traiki, Thamer Bin, Pandey, Manoj Kumar, Ahmad, Rehan, Srivastava, Sandeep Kumar

“…Colorectal cancer (CRC) is the second most common malignancy causing cancer-related mortality globally. It is the third most common type of cancer detected…”
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