Search Results - "Abdulazeez, Sayed"
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In-Silico Computing of the Most Deleterious nsSNPs in HBA1 Gene
Published in PloS one (29-01-2016)“…α-Thalassemia (α-thal) is a genetic disorder caused by the substitution of single amino acid or large deletions in the HBA1 and/or HBA2 genes. Using modern…”
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Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine
Published in Biomedicine & pharmacotherapy (01-07-2021)“…Migraine is a neurological ailment that is characterized by severe throbbing unilateral headache and associated with nausea, photophobia, phonophobia and…”
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Environmental and Genetic Factors in Autism Spectrum Disorders: Special Emphasis on Data from Arabian Studies
Published in International journal of environmental research and public health (23-02-2019)“…One of the most common neurodevelopmental disorders worldwide is autism spectrum disorder (ASD), which is characterized by language delay, impaired…”
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4
State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2
Published in Archives of medical science (2020)“…The extreme health and economic problems in the world due to the SARS-CoV-2 infection have led to an urgent need to identify potential drug targets for…”
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The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching
Published in PloS one (15-02-2019)“…B-cell lymphoma/leukaemia 11A (BCL11A) is a C2H2-type zinc-finger transcription factor protein that is a critical modulator of haemoglobin switching and…”
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6
Genome-Guided Identification of Surfactin-Producing Bacillus halotolerans AQ11M9 with Anti- Candida auris Potential
Published in International journal of molecular sciences (01-10-2024)“…The emergence of multidrug-resistant fungi is a worldwide health crisis connected with high rates of mortality. There is a critical need to find novel and…”
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SPIONs/3D SiSBA-16 based Multifunctional Nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines
Published in Scientific reports (10-10-2019)“…Multifunctional nanomaterials can be used for dual applications: drug delivery as well as in bioimaging. In current study, we investigated potential use of…”
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Phenomics and genomic features of Enterococcus avium IRMC1622a isolated from a clinical sample of hospitalized patient
Published in Journal of infection and public health (01-07-2024)“…Enterococcus avium (E. avium) is a Gram-positive nosocomial pathogen that is commonly isolated from the alimentary tract. The objective of this functional…”
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Genetic disorder prenatal diagnosis and pregnancy termination practices among high consanguinity population, Saudi Arabia
Published in Scientific reports (21-11-2019)“…The prevalence of consanguineous marriage and genetic disorders are high in Saudi Arabia. There were records on the practices of Saudis toward prenatal…”
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Genomic Insights into Virulence Factors and Multi-Drug Resistance in Clostridium perfringens IRMC2505A
Published in Toxins (25-05-2023)“…is a spore-forming, Gram-positive anaerobic pathogen that causes several disorders in humans and animals. A multidrug-resistant strain was isolated from the…”
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Emerging Status of Multidrug-Resistant Bacteria and Fungi in the Arabian Peninsula
Published in Biology (Basel, Switzerland) (06-11-2021)“…We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the…”
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12
Risk Y-haplotypes and pathogenic variants of Arab-ancestry boys with autism by an exome-wide association study
Published in Molecular biology reports (01-10-2020)“…Autism is heterogeneous multifactorial neurodevelopmental and neuropsychiatric disorder with repetitive and limited behaviors as well as communication…”
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13
Functional multigenic variations associated with hodgkin lymphoma
Published in International journal of laboratory hematology (01-12-2021)“…Introduction The current study aimed to describe genotypes associated with Hodgkin lymphoma (HL) in a cohort of Saudi and non‐Saudi patients and discuss their…”
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Highly deleterious variations in COX1, CYTB, SCG5, FK2, PRL and PGF genes are the potential adaptation of the immigrated African ostrich population
Published in Computers in biology and medicine (01-09-2018)“…Because of variable inconvenient living conditions in some places around the world, it is difficult to collect reliable physiological data for ostriches…”
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15
Novel Feather Degrading Keratinases from Bacillus cereus Group: Biochemical, Genetic and Bioinformatics Analysis
Published in Microorganisms (Basel) (01-01-2022)“…In this study, five keratinolytic bacteria were isolated from poultry farm waste of Eastern Province, Saudi Arabia. The highest keratinase activity was…”
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Therapeutic Intervention for Various Hospital Setting Strains of Biofilm Forming Candida auris with Multiple Drug Resistance Mutations Using Nanomaterial Ag-Silicalite-1 Zeolite
Published in Pharmaceutics (21-10-2022)“…( ), an emerging multidrug-resistant microorganism, with limited therapeutical options, is one of the leading causes of nosocomial infections. The current…”
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Safety of Tocilizumab in COVID-19 Patients and Benefit of Single-Dose: The Largest Retrospective Observational Study
Published in Pharmaceutics (11-03-2022)“…Severe acute respiratory coronavirus-2 (SARS-CoV-2) still presents a public threat and puts extra strain on healthcare facilities. Without an effective…”
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A comprehensive review of the prevalence of beta globin gene variations and the co-inheritance of related gene variants in Saudi Arabians with beta-thalassemia
Published in Saudi medical journal (01-04-2018)“…Beta-thalassemia is a genetic disorder that is caused by variations in the beta-hemoglobin (HBB) gene. Saudi Arabia is among the countries most affected…”
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The Potential of Dutasteride for Treating Multidrug-Resistant Candida auris Infection
Published in Pharmaceutics (01-06-2024)“…Novel antifungal drugs are urgently needed to treat candidiasis caused by the emerging fungal multidrug-resistant pathogen . In this study, the most…”
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Co-inheritance of alpha globin gene deletion lowering serum iron level in female beta thalassemia patients
Published in Molecular biology reports (2020)“…In the Eastern province of Saudi Arabia, thalassemia is highly common. Data on the effect of alpha globin gene variation on the concentration of iron on…”
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