Search Results - "Abdulahad, Wayel H"

Serum IL-23, IL-10, and TNF-α predict in-hospital mortality in COVID-19 patients by Smail, Shukur Wasman, Babaei, Esmaeil, Amin, Kawa, Abdulahad, Wayel H

“…The hyperinflammatory response, caused by severe acute respiratory syndrome-2 (SARS-CoV-2), is the most common cause of death in patients with coronavirus…”
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Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention by Kallenberg, Cees G.M., MD, PhD, Stegeman, Coen A., MD, PhD, Abdulahad, Wayel H., PhD, Heeringa, Peter, PhD

“…The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) comprise granulomatosis with polyangiitis (GPA), primarily associated with…”
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Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production by von Borstel, Anouk, Abdulahad, Wayel H, Dekkema, Gerjan, Rutgers, Abraham, Stegeman, Coen A, Veldman, Johanna, Heeringa, Peter, Sanders, Jan Stephan

“…Granulomatosis with polyangiitis (GPA) is an autoimmune disease affecting mainly small blood vessels. B-cells are important in the GPA pathogenesis as…”
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Disturbed B Cell Homeostasis in Newly Diagnosed Giant Cell Arteritis and Polymyalgia Rheumatica by Geest, Kornelis S. M., Abdulahad, Wayel H., Chalan, Paulina, Rutgers, Abraham, Horst, Gerda, Huitema, Minke G., Roffel, Mirjam P., Roozendaal, Caroline, Kluin, Philip M., Bos, Nicolaas A., Boots, Annemieke M. H., Brouwer, Elisabeth

“…Objective Several lines of evidence indicate that B cells may be involved in the immunopathology of giant cell arteritis (GCA) and polymyalgia rheumatica…”
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Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica by van Sleen, Yannick, Graver, Jacoba C, Abdulahad, Wayel H, van der Geest, Kornelis S M, Boots, Annemieke M H, Sandovici, Maria, Brouwer, Elisabeth

“…Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are inflammatory diseases requiring long-term glucocorticoid treatment. Limited data on dynamics in…”
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Monocyte subsets and monocyte-related chemokines in Takayasu arteritis by de Aguiar, Mariana Freitas, Torquato, Heron, Salu, Bruno Ramos, Oliveira, Ana Cecília Diniz, Oliva, Maria Luiza Vilela, Paredes-Gamero, Edgar Julian, Abdulahad, Wayel H., Brouwer, Elisabeth, de Souza, Alexandre W. S.

“…The pathogenesis of Takayasu arteritis (TAK) is poorly understood and no previous studies have analyzed monocytes in TAK. This study evaluated monocyte subsets…”
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B Cell Depletion Therapy Normalizes Circulating Follicular Th Cells in Primary Sjögren Syndrome by Verstappen, Gwenny M, Kroese, Frans G M, Meiners, Petra M, Corneth, Odilia B, Huitema, Minke G, Haacke, Erlin A, van der Vegt, Bert, Arends, Suzanne, Vissink, Arjan, Bootsma, Hendrika, Abdulahad, Wayel H

“…To assess the effect of B cell depletion therapy on effector CD4+ T cell homeostasis and its relation to objective measures of disease activity in patients…”
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Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis by van Sleen, Yannick, Wang, Qi, van der Geest, Kornelis S. M., Westra, Johanna, Abdulahad, Wayel H., Heeringa, Peter, Boots, Annemieke M. H., Brouwer, Elisabeth

“…Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia…”
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Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica by Reitsema, Rosanne D., Hesselink, Bernd-Cornèl, Abdulahad, Wayel H., van der Geest, Kornelis S. M., Brouwer, Elisabeth, Heeringa, Peter, van Sleen, Yannick

“…Background Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) are overlapping inflammatory diseases. Antigen-presenting cells (APCs), including…”
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T cells in vascular inflammatory diseases by Lintermans, Lucas L, Stegeman, Coen A, Heeringa, Peter, Abdulahad, Wayel H

“…Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases,…”
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Ferric carboxymaltose and SARS-CoV-2 vaccination-induced immunogenicity in kidney transplant recipients with iron deficiency: The COVAC-EFFECT randomized controlled trial by Vinke, Joanna Sophia J, Altulea, Dania H A, Eisenga, Michele F, Jagersma, Renate L, Niekolaas, Tessa M, van Baarle, Debbie, Heiden, Marieke van Der, Steenhuis, Maurice, Rispens, Theo, Abdulahad, Wayel H, Sanders, Jan-Stephan F, De Borst, Martin H

“…Kidney transplant recipients (KTRs) have an impaired immune response after vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)…”
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B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells by Bonasia, Carlo G., Abdulahad, Wayel H., Rutgers, Abraham, Heeringa, Peter, Bos, Nicolaas A.

“…Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and…”
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Increased expression of Toll-like receptors by monocytes and natural killer cells in ANCA-associated vasculitis by Tadema, Henko, Abdulahad, Wayel H, Stegeman, Coen A, Kallenberg, Cees G M, Heeringa, Peter

“…Toll-like receptors (TLRs) are a family of receptors that sense pathogen associated patterns such as bacterial cell wall proteins. Bacterial infections are…”
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Evidence for increased interferon type I activity in CD8+ T cells in giant cell arteritis patients by van Nieuwland, Marieke, Esen, Idil, Reitsema, Rosanne D, Abdulahad, Wayel H, van Sleen, Yannick, Jiemy, William F, Sandovici, Maria, Brouwer, Elisabeth, van Bon, Lenny

“…Giant cell arteritis (GCA) is a vasculitis of the medium- and large-sized arteries. Interferon type I (IFN-I) is increasingly recognized as a key player in…”
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Mucosal-associated invariant T cells in patients with axial spondyloarthritis by van der Meer, Rienk Gerben, Spoorenberg, Anneke, Brouwer, Elisabeth, Doornbos-van der Meer, Berber, Boots, Annemieke M H, Arends, Suzanne, Abdulahad, Wayel H

“…Several studies implicate Th17-cells and its cytokine (IL-17) in disease pathogenesis of spondyloarthritis (SpA), with available evidence supporting a…”
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Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica by Reitsema, Rosanne D, Jiemy, William F, Wekema, Lieske, Boots, Annemieke M H, Heeringa, Peter, Huitema, Minke G, Abdulahad, Wayel H, van Sleen, Yannick, Sandovici, Maria, Roozendaal, Caroline, Diepstra, Arjan, Kwee, Thomas, Dasgupta, Bhaskar, Brouwer, Elisabeth, van der Geest, Kornelis S M

“…Although polymyalgia rheumatica (PMR) is a very common rheumatic inflammatory disease, current insight into the pathobiology of PMR is limited and largely…”
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Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients by Lintermans, Lucas L, Rutgers, Abraham, Stegeman, Coen A, Heeringa, Peter, Abdulahad, Wayel H

“…Background Persistent expansion of circulating CD4.sup.+ effector memory T cells (T.sub.EM) in patients with granulomatosis with polyangiitis (GPA) suggests…”
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Checks and Balances in Autoimmune Vasculitis by Hid Cadena, Rebeca, Abdulahad, Wayel H, Hospers, G A P, Wind, T T, Boots, Annemieke M H, Heeringa, Peter, Brouwer, Elisabeth

“…Age-associated changes in the immune system including alterations in surface protein expression are thought to contribute to an increased susceptibility for…”
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Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells by Kallemeijn, Martine J., Boots, Anne Mieke H., van der Klift, Michèle Y., Brouwer, Elisabeth, Abdulahad, Wayel H., Verhaar, Jan A. N., van Dongen, Jacques J. M., Langerak, Anton W.

“…Ageing is a broad cellular process, largely affecting the immune system, especially T-lymphocytes. Additionally to immunosenescence alone, cytomegalovirus…”
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Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis by Dekkema, Gerjan J, Bijma, Theo, Jellema, Pytrick G, Van Den Berg, Anke, Kroesen, Bart-Jan, Stegeman, Coen A, Heeringa, Peter, Abdulahad, Wayel H, Sanders, Jan-Stephan

“…Regulatory T cells (Tregs) are frequently functionally impaired in patients with granulomatosis with polyangiitis (GPA). However, the mechanism underlying…”
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