Association Between Human Papillomavirus and Transitional Cell Carcinoma of the Bladder

Bladder carcinoma is one of the most common malignancies in worldwide. Among several risk factors, Human Papilloma Virus (HPV) have been presumed to play a causative role in the etiology of bladder cell carcinoma. The aim of this study was to evaluate the involvement of HPV infection in biopsy speci...

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Bibliographic Details
Published in:	Urology journal Vol. 14; no. 6; pp. 5047 - 5050
Main Authors:	Abdollahzadeh, Pourya, Madani, Seyed Hamid, Khazaei, Sedigheh, Sajadimajd, Soraya, Izadi, Babak, Najafi, Farid
Format:	Journal Article
Language:	English
Published:	Iran Urology and Nephrology Research Center 01-11-2017
Subjects:	Biopsy Bladder Bladder cancer Carcinoma, Transitional Cell - epidemiology Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - virology Case-Control Studies Female Human papillomavirus Humans Immunohistochemistry Iran - epidemiology Male Middle Aged Papillomavirus Infections - diagnosis Papillomavirus Infections - metabolism Risk Factors Urinary Bladder - pathology Urinary Bladder Neoplasms - epidemiology Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - virology Iran
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Summary:	Bladder carcinoma is one of the most common malignancies in worldwide. Among several risk factors, Human Papilloma Virus (HPV) have been presumed to play a causative role in the etiology of bladder cell carcinoma. The aim of this study was to evaluate the involvement of HPV infection in biopsy specimens of patients with transitional cell carcinoma at the west of Iran. In this study, 97 biopsy specimens including 67 patients with transitional cell carcinoma (TCC) of bladder and 30 cases of control group with the mean age of 63 years were studied using immunohistochemistry to identify HPV. 22.4% of patients with TCC of bladder and 3.3% of control group were positive for HPV with a meaningful relation (P=.019). The prevalence of HPV was 4.3 fold higher in men than women. Most TCC patients werebelonged to grades II and III. Considering the higher incidence of HPV positivity in patients with TCC of bladder compared to control group, it seems to be a meaningful association between HPV infection and TCC of bladder, at least in the west of Iran.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1735-1308 1735-546X
DOI:	10.22037/uj.v14i6.3748