Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

is a nosocomial pathogen and gram-negative coccobacillus that is responsible for opportunistic infections, pneumonia, and infections of the urinary tract, bloodstream, skin, and soft tissue. This bacterium poses a major public health problem due to inducing resistance to several drugs, isolates, mul...

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Bibliographic Details
Published in:	Infection and drug resistance Vol. 13; pp. 423 - 434
Main Authors:	Abdi, Seyyed Naser, Ghotaslou, Reza, Ganbarov, Khudaverdi, Mobed, Ahmad, Tanomand, Asghar, Yousefi, Mehdi, Asgharzadeh, Mohammad, Kafil, Hossein Samadi
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-02-2020 Taylor & Francis Ltd Dove Dove Medical Press
Subjects:	Acinetobacter baumannii Antibiotic resistance Antibiotics Antimicrobial agents Bacteria Bacterial infections biofilm Biofilms Cell division Chromosomes Drug resistance E coli efflux pumps Gene mutation Genetic aspects Health aspects Hospitals Infection Intensive care Microbial drug resistance Nosocomial infections Opportunistic infections Pathogenic microorganisms Pathogens Permeability Pneumonia Proteins Public health Public health movements Review Skin Tetracyclines Tigecycline transporters Urinary tract Urinary tract infections Iran Acinetobacter baumannii transporters antibiotic resistance efflux pumps biofilm
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Summary:	is a nosocomial pathogen and gram-negative coccobacillus that is responsible for opportunistic infections, pneumonia, and infections of the urinary tract, bloodstream, skin, and soft tissue. This bacterium poses a major public health problem due to inducing resistance to several drugs, isolates, multidrug treatment, and occasionally pan drugs. Drug resistance is not only a major concern caused by but also is considered as the main challenge in many other pathogens. Several factors such as the efflux pump are associated with antibiotic resistance, biofilm production, and genetic mutations. In this review, is introduced in then some of the practical works conducted on the existing efflux pump are reviewed. The importance of the efflux pump is considered in this paper in relation to the antibiotic resistance and mechanisms developed for the inhibition of these pumps as well.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1178-6973 1178-6973
DOI:	10.2147/idr.s228089