Search Results - "Abdelrahman, Mostafa H."

5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents by Youssif, Bahaa G.M., Mohamed, Ashraf M., Osman, Essam Eldin A., Abou-Ghadir, Ola F., Elnaggar, Dina H., Abdelrahman, Mostafa H., Treamblu, Laurent, Gomaa, Hesham A.M.

“…Cannabinoids as THC and the CB1 allosteric modulator CBD were reported to have antiproliferative activities with no reports for other CB1 allosteric modulators…”
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Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors by Abdelbaset, Mahmoud S., Abdel-Aziz, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Abbas Bukhari, Syed Nasir, Ali, Taha F.S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G M

“…A small set of indole-based derivatives, and - , was designed and synthesized. Compounds - demonstrated promising antiproliferative activity, with GI values…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors by Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.

“…A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both…”
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Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors by Al-Wahaibi, Lamya H, Mostafa, Yaser A, Abdelrahman, Mostafa H, El-Bahrawy, Ali H, Trembleau, Laurent, Youssif, Bahaa G. M

“…The apoptotic antiproliferative actions of our previously reported CB1 allosteric modulators 5-chlorobenzofuran-2-carboxamide derivatives VIIa–j prompted us to…”
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Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Youssif, Bahaa G.M., Shaykoon, Montaser Sh. A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •12 novel compounds contain Tetrahydrobenzo[4,5]Thieno[2,3-d]pyrimidinone as a novel cap group, attached to ZBG via aliphatic, aralkyl or…”
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Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity by Al-Wahaibi, Lamya H, Abou-Zied, Hesham A, Abdelrahman, Mostafa H, Morcoss, Martha M, Trembleau, Laurent, Youssif, Bahaa G M, Bräse, Stefan

“…The present study details the design, synthesis, and bio-evaluation of indoles as dual inhibitors of aromatase and inducible nitric oxide synthase (iNOS)with…”
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Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug by Abdu-Allah, Hajjaj H. M., Youssif, Bahaa G. M., Abdelrahman, Mostafa H., Abdel-Hamid, Mohammed K., Reshma, Rudraraju Srilakshmi, Yogeeswari, Perumal, Aboul-Fadl, Tarek, Sriram, Dharmarajan

“…The antitubercular drug; para -aminosalicylic acid (PAS) was used as the core scaffold for the design of a series of 1 H -1,2,3-triazolylsalicylhydrazones upon…”
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Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-Ib/I]indol-3-one Derivatives as Potent Inhibitors of EGFR[sup.T790M]/BRAF[sup.V600E] Pathways by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdelrahman, Mostafa H, Trembleau, Laurent, Youssif, Bahaa G. M

“…Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We…”
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Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity by Mohamed, Fatma A.M., Gomaa, Hesham A.M., Hendawy, O.M., Ali, Asmaa T., Farghaly, Hatem S., Gouda, Ahmed M., Abdelazeem, Ahmed H., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G.M.

“…[Display omitted] •A series of novel indole-2-carboxmide derivatives 9–23 as EGFR inhibitors has been designed and synthesized.•Compounds 10, 11, 13, 15 and…”
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New potent ciprofloxacin-uracil conjugates as DNA gyrase and topoisomerase IV inhibitors against methicillin-resistant Staphylococcus aureus by Samir, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Elbastawesy, Mohammed A.I., Halby, Hamada Mohamed, Abdel-Aziz, Mohamed, Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •New ciprofloxacin-uracil conjugates were prepared and characterized.•Promising activity against S. aureus ATCC 6538 better than the…”
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Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities by Gomaa, Hesham A.M., Shaker, Mohamed E., Alzarea, Sami I., Hendawy, O.M., Mohamed, Fatma A.M., Gouda, Ahmed M., Ali, Asmaa T., Morcoss, Martha M., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G.M.

“…[Display omitted] •A series of 2,3-dihydropyrazino[1,2-a]indole-1,4-diones 13–22 as dual EGFR/ BRAFV600E inhibitors has been developed.•Compounds 15 and 19–22…”
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Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity by Abdelrahman, Mostafa H., Youssif, Bahaa G.M., abdelgawad, Mohamed A., Abdelazeem, Ahmed H., Ibrahim, Hussein M., Moustafa, Abd El Ghany A., Treamblu, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel quinoline-2-carboxamides 15–28 was synthesized and evaluated in vitro as dual COXs/LOX inhibitors. Compounds 19 and 27 exhibited the highest…”
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Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors by Abdelbaset, Mahmoud S., Abuo-Rahma, Gamal El-Din A., Abdelrahman, Mostafa H., Ramadan, Mohamed, Youssif, Bahaa G.M., Bukhari, Syed Nasir Abbas, Mohamed, Mamdouh F.A., Abdel-Aziz, Mohamed

“…[Display omitted] •Novel quinolinyl pyrrolone and quinolinyl pyridazinone derivatives.•Antiproliferative activity.•BRAF kinase inhibition.•Tubulin…”
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Design and synthesis of pyrazolo[3,4-d]pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma by Elshaier, Yaseen A.M.M., Shaaban, Mohamed A., Abd El Hamid, Mohammed K., Abdelrahman, Mostafa H., Abou-Salim, Mahrous A., Elgazwi, Sara M., Halaweish, Fathi

“…[Display omitted] A new series of pyrazolo[3,4-d]pyrimidines tethered with nitric oxide (NO) producing functionality was designed and synthesized…”
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Design, synthesis and pharmacophoric model building of new 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamides with potential antiproliferative activity by Abdelrahman, Mostafa H., Aboraia, Ahmed S., Youssif, Bahaa G. M., Elsadek, Bakheet E. M.

“…Novel 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamide derivatives were synthesized and evaluated for their anticancer activity. Most of the tested compounds…”
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Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR WT/ EGFR T790M inhibitors by Al-Wahaibi, Lamya H, Mohammed, Anber F, Abdel Rahman, Fatema El-Zahraa S, Abdelrahman, Mostafa H, Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G M

“…A new series of indole-2-carboxamides , and pyrido[3,4-b]indol-1-ones and have been developed as new antiproliferative agents that target both wild and mutant…”
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Receptor conformational change induces fluoride binding despite competitive water binding by Trembleau, Laurent, Smith, Tim A D, Abdelrahman, Mostafa H

“…Fluoride binding by artificial receptors in water remains a challenging task due to the high hydration enthalpy of this anion. A novel cationic boron-based…”
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