Search Results - "Abdelrahman, Kamal S."
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Development and Assessment of 1,5–Diarylpyrazole/Oxime Hybrids Targeting EGFR and JNK–2 as Antiproliferative Agents: A Comprehensive Study through Synthesis, Molecular Docking, and Evaluation
Published in Molecules (Basel, Switzerland) (01-09-2023)“…New 1,5-diarylpyrazole oxime hybrid derivatives (scaffolds A and B) were designed, synthesized, and then their purity was verified using a variety of…”
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Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights
Published in Journal of enzyme inhibition and medicinal chemistry (01-12-2023)“…This research study describes the development of new small molecules based on 2,4-thiazolidinedione (2,4-TZD) and their aldose reductase (AR) inhibitory…”
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Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation
Published in Bioorganic chemistry (01-09-2020)“…[Display omitted] •A series of novel 1,6-dihydropyrimidin-2-thio was designed and synthesized.•Compounds 3a, 3b, 3e and 4b were selected for in vitro…”
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Utility of Cilefa Pink B, a foodstuff dye as a fluoro-substrate in the devising of the first facile green Molecular-mass-Related Fluorescence Sensor for quantifying amlodipine in batched material and dosage forms; content uniformity evaluation
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-03-2024)Get full text
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Design of Multi-Target drugs of HDACs and other Anti-Alzheimer related Targets: Current strategies and future prospects in Alzheimer’s diseases therapy
Published in Bioorganic chemistry (01-10-2024)“…[Display omitted] •The HDACs ability to synergistically boost the performance of other anti-AD drugs, as well as the ease with which HDACs inhibitor cap group,…”
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Integration of a facile sustainable resonance Rayleigh scattering switchable-based system for feasible determination of centrophenoxine, a nootropic and antioxidant agent; application to crude materials and dosage forms
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (15-05-2024)“…A simple scheming summarizing the planned method and giving overall picture about the article concerns, CPX-Erythrosine B coupled product suggested mechanism,…”
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A new application of isoindole fluorophore derivative in sitagliptin antidiabetic medication assay: Application to dosage forms and biological fluid evaluation
Published in Luminescence (Chichester, England) (01-06-2023)“…Dipeptidyl peptidase‐4 enzyme suppressant is a unique category of oral antidiabetic medication. Sitagliptin (STG) is a perfect member of this category and is…”
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Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing
Published in Luminescence (Chichester, England) (01-01-2024)“…The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that…”
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Factorial design-aided derivatization-free fluorimetric ultrasensitive assay of vonoprazan with application in uniformity of dosage units and plasma samples analysis: Comprehensive and comparative greenness and whiteness assessment
Published in Microchemical journal (01-10-2024)“…[Display omitted] •A novel factorial design-optimized spectrofluorimetric method for vonoprazan without pre-derivatization.•Complex formation between…”
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Roth's switch-on fluoremetric probe for green tracking and quantifying of 1.4-dihydropyridine medication: Evaluation of greenness, whiteness, and blueness
Published in Sustainable chemistry and pharmacy (01-12-2023)“…Facile incorporation of a fluorescence-modulating moiety to decorate a molecular derivatized system for an ultrasensitive quantifying of an individual of…”
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