Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women

Red blood cell distribution width and iron deficiency anemia among pregnant Sudanese women

Iron deficiency anemia (IDA) is a major health problem during pregnancy and it has adverse effects on the mother and the newborn. Red cell distribution width (RDW), which is a quantitative measure for red cell size variation (anisocytosis), is a predictor of IDA. Little is known regarding RDW and ID...

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Bibliographic Details
Published in:Diagnostic pathology Vol. 7; no. 1; p. 168
Main Authors: Abdelrahman, Esam G, Gasim, Gasim I, Musa, Imad R, Elbashir, Leana M, Adam, Ishag
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 03-12-2012
BioMed Central
BMC
Subjects:
Adult
Anemia
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - diagnosis
Biomarkers - blood
Blood
Care and treatment
Cross-Sectional Studies
Development and progression
Diagnosis
Erythrocyte Indices
Erythrocytes
Female
Ferritin
Ferritins - blood
Gestational Age
Health aspects
Humans
Iron
Iron deficiency anemia
Medical examination
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Hematologic - blood
Pregnancy Complications, Hematologic - diagnosis
Pregnant women
Red cell distribution width
Sensitivity and Specificity
Studies
Sudan
Womens health
Young Adult
Sudan
Africa
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Summary:Iron deficiency anemia (IDA) is a major health problem during pregnancy and it has adverse effects on the mother and the newborn. Red cell distribution width (RDW), which is a quantitative measure for red cell size variation (anisocytosis), is a predictor of IDA. Little is known regarding RDW and IDA during pregnancy. A cross sectional study was conducted at the antenatal clinic of Khartoum Hospital, Sudan, to determine the performance of RDW in the diagnosis of IDA using serum ferritin as a gold standard. Among 194 pregnant women with a gestational period of 21.4 ± 6.5 weeks, 57 (29.4%) had IDA according to serum ferritin levels (<15 μg/l) and 61 (31.4%) had IDA according to RDW (>14.5). The sensitivity, specificity, positive predictive value, and negative predictive value of RDW where serum ferritin was the gold standard were 43.8% (95% CI: 31.4-57.0%), 73.7% (95% CI: 65.8-80.5%), 41.0% (95% CI: 29.2-53.6%), and 76.0% (95% CI: 68.1-82.6%), respectively. In this study, we found that RDW has a poor performance in diagnosing IDA among pregnant women compared with serum ferritin as the gold standard.
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ISSN:1746-1596
1746-1596
DOI:10.1186/1746-1596-7-168