Search Results - "Abdellatif, Khaled R.A."

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies by Fadaly, Wael A.A., Elshaier, Yaseen A.M.M., Hassanein, Emad H.M., Abdellatif, Khaled R.A.

“…[Display omitted] •Two new series of hybrid structures 16a-f and 19a-f containing 1,2,4-triazole and pyrazole were synthesized.•16a-f and 19a-f showed good in…”
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Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors by Abdellatif, Khaled R.A., Abdelgawad, Mohamed A., Labib, Madlen B., Zidan, Taha H.

“…[Display omitted] A new series of triarylpyrazoline derivatives 8a–p containing the most important COX-2 pharmacophore (SO2CH3 or/and SO2NH2) were synthesized…”
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Nitric Oxide-NASIDS Donor Prodrugs as Hybrid Safe Anti-inflammatory Agents by Abdellatif, Khaled R A, Abdelall, Eman K A, Bakr, Rania B

“…Selective inhibition of cyclooxygenase-2 (COX-2) isozyme afforded a useful drug design concept that resulted in the development of effective anti-inflammatory…”
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Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues by Abdellatif, Khaled R.A., Belal, Amany, Omar, Hany A.

“…Design of novel tamoxifen analogs with potential activity against breast cancer cell lines, compounds 5c and 5e showed inhibitory activity in a micromolar…”
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Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones by Abdellatif, Khaled R A, Elbadawi, Mostafa M, Elsaady, Mohammed T, Abd El-Hafeez, Amer A, Fujimura, Takashi, Kawamoto, Seiji, Khodair, Ahmed I

“…Some 2-thioxoimidazolidinones have been reported as anti-prostate and anti-breast cancer agents through their inhibitory activity on topoisomerase I that is…”
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Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: Synthesis, biological evaluation and nitric oxide release studies by Abdellatif, Khaled R.A., Chowdhury, Morshed Alam, Dong, Ying, Das, Dipankar, Yu, Gang, Velázquez, Carlos A., Suresh, Mavanur R., Knaus, Edward E.

“…A new group of hybrid nitric oxide (NO) releasing anti-inflammatory (AI) ester prodrugs (NONO-NSAIDs) wherein a 1,3-dinitrooxy-2-propyl (12a–c), or…”
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Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: Dual Inhibitors of cyclooxygenases and 5-lipoxygenase by Yu, Gang, Praveen Rao, P.N., Chowdhury, Morshed A., Abdellatif, Khaled R.A., Dong, Ying, Das, Dipankar, Velázquez, Carlos A., Suresh, Mavanur R., Knaus, Edward E.

“…A new group of acetic acid ( 7a– c, R 1 = H), and propionic acid ( 7d– f, R 1 = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is…”
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A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5 H -furan-2-one: Synthesis, biological evaluation and nitric oxide release studies by Abdellatif, Khaled R.A., Huang, Zhangjian, Chowdhury, Morshed A., Kaufman, Susan, Knaus, Edward E.

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Triaryl ( Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors by Abdellatif, Khaled R.A., Velázquez, Carlos A., Huang, Zhangjian, Chowdhury, Morshed A., Knaus, Edward E.

“…A group of ( Z)-1,2-diphenyl-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]but-1-enes were synthesized using methodologies that will allow incorporation of a […”
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Synthesis of certain 8-quinolyloxy and/or carbocyclic nitrogenous compounds for microbiological testing by Khaled R.A. Abdellatif, Madlen B. Labib, Ossama M. El-Badry, Sameha M.A. Roshdy, Mervat M. El-Enany

“…Two new series as azosalicylic acid derivatives IVa-l and Va-c in addition to three series containing 8-quinolyloxy moiety Xa-i, XIIa-n and XIVa-e were…”
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Synthesis of phenylacetic acid regioisomers possessing an N-substituted 1,2-dihydropyrid-2-one pharmacophore — Evaluation as inhibitors of cyclooxygenases and 5-lipoxygenase by Yu, Gang, Chowdhury, Morshed A, Huang, Zhangjian, Abdellatif, Khaled R.A, Knaus, Edward E

“…The Suzuki–Miyaura cross-coupling reaction provides a useful method for the synthesis of methyl 2-(2-chloropyridyl or 2-methoxypyridyl)phenylacetates. The…”
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Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers by Chowdhury, Morshed Alam, Dong, Ying, Chen, Qiao-Hong, Abdellatif, Khaled R.A., Knaus, Edward E.

“…A group of 1-(aminosulfonylphenyl and methylsulfonylphenyl)-2-(pyridyl)acetylene regioisomers were designed such that a COX-2 SO 2NH 2 pharmacophore was…”
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Synthesis and antimicrobial evaluation of certain purine, benzothiazole and thiazole systems substituted with dialkylaminoalkyl-o-cresols by Khaled R.A. Abdellatif, Ghada A. Abd El Wareth, Ossama M. El-Badry, Hamdy M. Ragab, Mervat M. El-Enany

“…Novel series of dialkylaminoalkyl-o-cresols incorporated with purine nucleus 2a–b, benzothiazole nucleus 5a–b, 8a–b and thiazole nucleus 11a–d, 13a–d were…”
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Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment by Abdellatif, Khaled R. A., Bakr, Rania B.

“…Pyrimidine ring and its fused derivatives including pyrazolo[3,4- d ]pyrimidine, pyrido[2,3- d ]pyrimidine, quinazoline, and furo[2,3- d ]pyrimidine compounds…”
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New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds by Abdellatif, Khaled R.A., Bakr, Rania B.

“…Pyrazolo[3,4-d]pyrimidine ring system constitute an important class of heterocyclic compounds which can serve as a promising scaffold exhibiting many…”
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Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments by Elbadawi, Mostafa M., Khodair, Ahmed I., Awad, Mohamed K., Kassab, Shaymaa E., Elsaady, Mohammed T., Abdellatif, Khaled R.A.

“…•Novel 5a–c and 6a–c were designed and synthesized based on 3 that has been reported to have cytotoxicity with topo I inhibition.•The structures of all…”
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Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors by Abdellatif, Khaled R.A., Fadaly, Wael A.A., Kamel, Gehan M., Elshaier, Yaseen A.M.M., El-Magd, Mohammed A.

“…[Display omitted] •Twelve thiazolidine derivatives 12a-f and 13a-f were designed and synthesized.•12e-f and 13a-f showed good in vitro COX-2 selectivity and in…”
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Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS by Abdellatif, Khaled R.A., Belal, Amany, El-Saadi, Mohamed T., Amin, Noha H., Said, Eman G., Hemeda, Loah R.

“…[Display omitted] •A series of hybridized benzothiazole pyrimidine-based on targeting EGFR/HER2 and TS enzymes was designed and synthesized.•They were…”
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Design, synthesis of new anti-inflammatory agents with a pyrazole core: COX-1/COX-2 inhibition assays, anti-inflammatory, ulcerogenic, histopathological, molecular Modeling, and ADME studies by Abdellatif, Khaled R.A., Abdelall, Eman K.A., Elshemy, Heba A.H., Lamie, Phoebe F., Elnahaas, Elshaymaa, Amin, Dina M.E.

“…•Design and synthesis of twenty two pyrazole derivatives.•Compounds 5b, 6a, 6b, 11b, 13a, 13c, 14a, and 14c all with (SO2CH3 or SO2NH2 - COX-2 pharmacophores)…”
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3-methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents by Abdellatif, Khaled R A, Lamie, Phoebe F, Omar, Hany A

“…In a new group of 3-methyl-2-phenyl-1-substituted-indole derivatives (10a-f), the indomethacin analogs were prepared via the Fisher indole synthesis reaction…”
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