Search Results - "Abdellatif, Khaled R A"

Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives by Bakr, Rania B, Mehany, Ahmed B M, Abdellatif, Khaled R A

“…as EGFR inhibitors, mammalian target of rapamycin (mTOR) inhibitors, Src or dual Src/Abl inhibitors, glycogen synthase kinase-3b (GSK-3b) inhibitors or cyclin…”
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Ethanesulfohydroxamic Acid Ester Prodrugs of Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory, and Ulcerogenicity Index Studies by Huang, Zhangjian, Velázquez, Carlos A, Abdellatif, Khaled R. A, Chowdhury, Morshed A, Reisz, Julie A, DuMond, Jenna F, King, S. Bruce, Knaus, Edward E

“…The carboxylic acid group of the anti-inflammatory (AI) drugs indo-methacin, (S)-naproxen and ibuprofen was covalently linked via a two-carbon ethyl spacer to…”
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Synthesis and biological evaluation of 2-(4-methylsulfonyl phenyl) indole derivatives: multi-target compounds with dual antimicrobial and anti-inflammatory activities by Shaker, Ahmed M. M., Abdelall, Eman K. A., Abdellatif, Khaled R. A., Abdel-Rahman, Hamdy M.

“…Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their…”
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Synthesis and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing an aminosulphonyl pharmacophore by Abdellatif, Khaled R. A, Abdelgawad, Mohamed A, Elshemy, Heba A. H, Alsayed, Shahinda S. R, Kamel, Gehan

“…A novel series of 2-pyrazoline derivatives 13a–l was synthesized via aldol condensation of 4-substituted acetophenones with appropriately substituted aldehydes…”
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Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities by A A Fadaly, Wael, A M M Elshaier, Yaseen, T M Nemr, Mohamed, R A Abdellatif, Khaled

“…[Display omitted] •Twelve pyrazole derivatives 10a-f and 11a-f were designed and synthesized.•10e-f and 11a-f showed good in vitro COX-2 selectivity.•10c, 11a…”
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Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity by Chowdhury, Morshed A, Abdellatif, Khaled R. A, Dong, Ying, Das, Dipankar, Suresh, Mavanur R, Knaus, Edward E

“…A novel class of 1-(4-methanesulfonylphenyl and 4-aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole hybrid…”
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Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies by Abdellatif, Khaled R.A., Chowdhury, Morshed A., Velázquez, Carlos A., Huang, Zhangjian, Dong, Ying, Das, Dipankar, Yu, Gang, Suresh, Mavanur R., Knaus, Edward E.

“…A new class of anti-inflammatory (AI) cupferron prodrugs was synthesized wherein a diazen-1-ium-1,2-diolato ammonium salt, and its O2-methyl and…”
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Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2 H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: A search for novel nitric oxide donor anti-inflammatory agents by Chowdhury, Morshed Alam, Abdellatif, Khaled R.A., Dong, Ying, Knaus, Edward E.

“…A group of 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2 H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines ( 11– 14) possessing a variety of substituents…”
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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study by Fadaly, Wael A A, Nemr, Mohamed T M, Zidan, Taha H, Mohamed, Fatma E A, Abdelhakeem, Marwa M, Abu Jayab, Nour N, Omar, Hany A, Abdellatif, Khaled R A

“…A new series of bis-triazole 19a-l was synthesised for the purpose of being hybrid molecules with both anti-inflammatory and anti-cancer activities and…”
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Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: Dual Inhibitors of cyclooxygenases and 5-lipoxygenase by Yu, Gang, Praveen Rao, P.N., Chowdhury, Morshed A., Abdellatif, Khaled R.A., Dong, Ying, Das, Dipankar, Velázquez, Carlos A., Suresh, Mavanur R., Knaus, Edward E.

“…A new group of acetic acid ( 7a– c, R 1 = H), and propionic acid ( 7d– f, R 1 = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is…”
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New indomethacin analogs as selective COX‐2 inhibitors: Synthesis, COX‐1/2 inhibitory activity, anti‐inflammatory, ulcerogenicity, histopathological, and docking studies by Abdellatif, Khaled R. A., Abdelall, Eman K. A., Elshemy, Heba A. H., El‐Nahass, El‐Shaymaa, Abdel‐Fattah, Maha M., Abdelgawad, Yasmin Y. M.

“…New indomethacin analogs 4a–g, 5, 6, 8a, and 8b were synthesized to overcome the nonselectivity and ulcer liability of indomethacin. All newly synthesized…”
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Synthesis and anticancer activity of some new pyrazolo[3,4-d]pyrimidin-4-one derivatives by Abdellatif, Khaled R A, Abdelall, Eman K A, Abdelgawad, Mohamed A, Ahmed, Rasha R, Bakr, Rania B

“…3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-d][1,3]oxazin-4-one (3) was prepared by hydrolysis of ethyl 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carboxylate (1) to…”
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Triaryl ( Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors by Abdellatif, Khaled R.A., Velázquez, Carlos A., Huang, Zhangjian, Chowdhury, Morshed A., Knaus, Edward E.

“…A group of ( Z)-1,2-diphenyl-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]but-1-enes were synthesized using methodologies that will allow incorporation of a […”
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Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile by Abdellatif, Khaled R.A., Abdelgawad, Mohamed A., Elshemy, Heba A.H., Alsayed, Shahinda S.R.

“…[Display omitted] •Two groups of thiazolidin-4-ones 4a–c and 8a–e were designed and synthesized.•Compounds 8c and 8d showed the best overall in vitro COX-2…”
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Synthesis, cyclooxygenase inhibition and anti-inflammatory evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing methanesulphonyl pharmacophore by Abdellatif, Khaled R A, Elsaady, Mohammed T, Abdel-Aziz, Salah A, Abusabaa, Ahmed H A

“…A new series of 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives 13a-p were synthesized via aldol condensation of 3/4-nitroacetophenones with appropriately…”
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Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,5-diarylpyrazole derivatives by Abdellatif, Khaled R A, Fadaly, Wael A A, Ali, Waleed A M, Kamel, Gehan M

“…A new series of 1,5-diarylpyrazoles 10a-l was designed and synthesized for evaluation as COX inhibitors and as anti-inflammatory agents. All compounds were…”
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Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: A search for novel nitric oxide donor anti-inflammatory agents by Abdellatif, Khaled R.A., Moawad, Abeer, Knaus, Edward E.

“…[Display omitted] A group of 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles (12a–f) was synthesized and…”
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Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies by Chowdhury, Morshed A., Abdellatif, Khaled R.A., Dong, Ying, Yu, Gang, Huang, Zhangjian, Rahman, Moshfiqur, Das, Dipankar, Velázquez, Carlos A., Suresh, Mavanur R., Knaus, Edward E.

“…A new group of hybrid nitric oxide (NO) releasing anti-inflammatory (AI) coxib prodrugs (NO-coxibs) wherein the para-tolyl moiety present in celecoxib was…”
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Synthesis and Biological Evaluation of New Diarylpyrazole and Triarylimidazoline Derivatives as Selective COX‐2 Inhibitors by Abdellatif, Khaled R.A., Abdelgawad, Mohamed A., Labib, Madlen B., Zidan, Taha H.

“…New series of diarylpyrazoles 8a–f and triarylimidazoline‐5‐ones 11a–g were synthesized and evaluated for their in vitro cyclooxygenase‐1 (COX‐1) and COX‐2…”
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Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-( N-hydroxypyridin-2(1 H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitors by Chowdhury, Morshed Alam, Chen, Hua, Abdellatif, Khaled R.A., Dong, Ying, Petruk, Kenneth C., Knaus, Edward E.

“…A hitherto unknown class of linear acetylene regioisomers were designed such that a SO 2NH 2 group was located at the ortho-, meta-, or para-position of the…”
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