Search Results - "Abdelkawy, Khaled"
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The Antihypertensive Effect of Quercetin in Young Spontaneously Hypertensive Rats; Role of Arachidonic Acid Metabolism
Published in International journal of molecular sciences (08-09-2020)“…Hypertension affects almost 50% of the adult American population. Metabolites of arachidonic acid (AA) in the kidney play an important role in blood pressure…”
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A new validated HPLC method for the determination of quercetin: Application to study pharmacokinetics in rats
Published in Biomedical chromatography (01-03-2017)“…A simple, accurate, and reproducible high‐performance liquid chromatography (HPLC) method has been developed and validated for the quantification of quercetin…”
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Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors
Published in European journal of drug metabolism and pharmacokinetics (01-06-2017)“…Up-regulation of arginase activity in several chronic disease conditions, including cancer and hypertension, may suggest new targets for treatment. Recently,…”
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Simple HPLC-UV Method for Piperacillin/Tazobactam Assay in Human Plasma
Published in Antibiotics (Basel) (03-02-2023)“…Piperacillin (Pip)/tazobactam (Taz) is a broad-spectrum antimicrobial agent that has been commonly used in the intensive care unit for severe and…”
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Unveiling the lockdown effects: exploring behavior, dietary habits and weight changes in rural Egypt during COVID-19 lockdown: a cross-sectional retrospective study
Published in Journal of health, population and nutrition (15-06-2024)“…The COVID-19 lockdown significantly impacted dietary habits and body weights globally, particularly in Egypt, where 57.03% of the population resides in rural…”
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Changes in dietary habits during Covid-19 lockdown in Egypt: the Egyptian COVIDiet study
Published in BMC public health (25-05-2023)“…COVID-19 lockdown changed social habits and lifestyle, including dietary habits, of people worldwide. However, limited information is available about these…”
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Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers
Published in European journal of drug metabolism and pharmacokinetics (01-06-2020)“…Background and Objectives Green tea catechins were recently reported to inhibit drug transporters such as organic anion-transporting polypeptides (OATPs) and…”
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Prevalence of Drug-Drug Interactions in Primary Care Prescriptions in Egypt: A Cross-Sectional Retrospective Study
Published in Pharmacy (18-06-2023)“…In clinical practice, drug-drug interactions (DDIs) pose significant risks to a large number of patients. Consequently, healthcare providers are required to…”
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Effects of Lemon and Seville Orange Juices on the Pharmacokinetic Properties of Sildenafil in Healthy Subjects
Published in Drugs in R&D (01-09-2016)“…Purpose Several severe drug interactions have been reported when sildenafil, a potent drug for the treatment of erectile dysfunction, is co-administered with…”
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Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities
Published in Pharmacognosy Magazine (01-10-2017)“…Background: Quercetin (QR) and thymoquinone (TQ) are herbal remedies that are currently extensively used by the general population to prevent and treat various…”
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The promising role of CCL2 as a noninvasive marker for nonalcoholic steatohepatitis diagnosis in Egyptian populations
Published in European journal of gastroenterology & hepatology (01-12-2021)“…Nonalcoholic fatty liver disease (NAFLD) is a common liver problem, including both nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). In…”
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Clinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study
Published in Clinical drug investigation (01-12-2023)“…Background and Objectives Tramadol is a centrally acting analgesic with a lower risk of addiction compared to opioids. Tramadol overdose is becoming a health…”
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The effects of genetic polymorphism on toxicity and pharmacokinetics of methotrexate in Egyptian adult patients with leukaemia or lymphoma
Published in Xenobiotica (07-02-2024)“…Polymorphisms in genes coding folate-metabolising enzymes might alter the pharmacokinetics and sensitivity for methotrexate "MTX".The aim of the study aimed to…”
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Effect of Dietary Doses of Quercetin on Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats
Published in European journal of drug metabolism and pharmacokinetics (01-12-2019)“…Background Administration of quercetin (QR) has shown several health benefits in clinical and pre-clinical studies. Objective This study investigates the…”
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