Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease

Adiponectin rs1501299 and chemerin rs17173608 gene polymorphism in children with type 1 diabetes mellitus: relation with macroangiopathy and peripheral artery disease

Aim Although macrovascular complications represent the leading cause of mortality in type 1 diabetes mellitus (T1DM), the prevalence of subtle macrovascular affection including peripheral artery disease (PAD) among children with T1DM and its genetic predictors remains to be unraveled. Increasing evi...

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Published in:Journal of endocrinological investigation Vol. 47; no. 4; pp. 983 - 994
Main Authors: Salah, N. Y., Madkour, S. S., Ahmed, K. S., Abdelhakam, D. A., Abdullah, F. A., Mahmoud, R. A. E. H.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-04-2024
Springer Nature B.V
Subjects:
Adiponectin
Alleles
Ankle
Atherogenesis
Children
Cholesterol
Diabetes
Diabetes mellitus (insulin dependent)
Endocrinology
Gene polymorphism
Hemoglobin
High density lipoprotein
Hyperlipidemia
Insulin resistance
Internal Medicine
Lipids
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Polymorphism
Vascular diseases
Vein & artery diseases
Chemerin
Peripheral artery disease
Children
Type 1 diabetes
Adiponectin
Polymorphism
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Summary:Aim Although macrovascular complications represent the leading cause of mortality in type 1 diabetes mellitus (T1DM), the prevalence of subtle macrovascular affection including peripheral artery disease (PAD) among children with T1DM and its genetic predictors remains to be unraveled. Increasing evidence suggests a link between adiponectin rs1501299 and chemerin rs17173608 gene polymorphism and atherogenesis, and insulin resistance. Hence, this study assess the prevalence of these variants among children with T1DM in comparison to healthy controls and their association with macrovascular complications, namely PAD and hyperlipidemia. Methods Fifty children with T1DM and 50 matched controls underwent a thorough assessment including adiponectin rs1501299 and chemerin rs17173608 gene polymorphisms, fasting lipids, glycated hemoglobin (HbA1c), and ankle–brachial index (ABI). Cochran–Armitage trend test was used to decide the risk allele and evaluate the association between the candidate variant and PAD using a case–control design. Results Children with T1DM were found to have significantly higher ABI ( p  = 0.011) than controls. Chemerin gene polymorphism was detected in 41 children with T1DM (82.0%), while adiponectin gene polymorphism was detected in 19 children (38.0%). Children with T1DM having GG chemerin variant and those having TT adiponectin variant had significantly higher cholesterol with significantly lower HDL-C and ABI than those having the other two variants ( p  < 0.005). Children with T1DM having abnormal ABI had significantly higher chemerin G ( p  = 0.017) and adiponectin T ( p  = 0.022) alleles than those with normal ABI. Cholesterol and ABI were independently associated with chemerin and adiponectin gene polymorphism by multivariable regression analysis. Conclusion Children with T1DM having chemerin and adiponectin gene polymorphisms have significantly higher cholesterol and ABI than those without these polymorphisms and controls. Trial registration The Research Ethics Committee of Ain Shams University, approval number R 31/2021.
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ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02215-z