Search Results - "Abdelgawad, Ibrahim Y."

Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction by Grant, Marianne K. O, Abdelgawad, Ibrahim Y, Lewis, Christine A, Seelig, Davis, Zordoky, Beshay N, Lionetti, Vincenzo

“…Sex-related differences in cardiovascular diseases are highly complex in humans and model-dependent in experimental laboratory animals. The objective of this…”
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Canagliflozin mitigates carfilzomib-induced endothelial apoptosis via an AMPK-dependent pathway by Dabour, Mohamed S., Abdelgawad, Ibrahim Y., Grant, Marianne K.O., El-Sawaf, Engie S., Zordoky, Beshay N.

“…Carfilzomib (CFZ) is a proteasome inhibitor approved for relapsed/refractory multiple myeloma (MM) but its clinical use is limited by cardiovascular toxicity…”
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Losmapimod ameliorates doxorubicin-induced cardiotoxicity through attenuating senescence and inflammatory pathways by Dabour, Mohamed S., Abdelgawad, Ibrahim Y., Sadaf, Bushra, Daniel, Mary R., Grant, Marianne K.O., Seelig, Davis, Zordoky, Beshay N.

“…Irreversible cardiotoxicity limits the clinical application of doxorubicin (DOX). DOX-induced cardiotoxicity has been associated with induction of senescence…”
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Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation by Grant, Marianne K O, Abdelgawad, Ibrahim Y, Lewis, Christine A, Zordoky, Beshay N

“…Doxorubicin (DOX) is an effective chemotherapeutic agent used to treat a wide variety of malignancies. In addition to its multi-organ toxicity, DOX treatment…”
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Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells by Abdelgawad, Ibrahim Y, Agostinucci, Kevin, Sadaf, Bushra, Grant, Marianne K O, Zordoky, Beshay N

“…Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial…”
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Doxorubicin Paradoxically Ameliorates Tumor-Induced Inflammation in Young Mice by Abdelgawad, Ibrahim Y, Grant, Marianne K O, Popescu, Flavia E, Largaespada, David A, Zordoky, Beshay N

“…Doxorubicin (DOX) is one of the most widely used chemo-therapeutic agents in pediatric oncology. DOX elicits an inflammatory response in multiple organs, which…”
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Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology by Abdelgawad, Ibrahim Y, Grant, Marianne K O, Zordoky, Beshay N

“…Cardio-oncology is a clinical/scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of…”
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Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice by Grant, Marianne K O, Seelig, Davis M, Sharkey, Leslie C, Choi, Wan S V, Abdelgawad, Ibrahim Y, Zordoky, Beshay N

“…Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female…”
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Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice by Grant, Marianne K. O., Razzoli, Maria, Abdelgawad, Ibrahim Y., Mansk, Rachel, Seelig, Davis, Bartolomucci, Alessandro, Zordoky, Beshay N.

“…Childhood cancer survivors have a high risk for premature cardiovascular diseases, mainly due to cardiotoxic cancer treatments such as doxorubicin (DOX)…”
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EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263 by Abdelgawad, Ibrahim Y, Agostinucci, Kevin, Ismail, Somia G, Grant, Marianne K O, Zordoky, Beshay N

“…Doxorubicin (DOX) induces endothelial cell (EC) senescence, which contributes to endothelial dysfunction and cardiovascular complications. Senolytic drugs…”
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Cardiovascular ramifications of therapy-induced endothelial cell senescence in cancer survivors by Abdelgawad, Ibrahim Y, Agostinucci, Kevin, Zordoky, Beshay N

“…Cancer survivorship has remarkably improved over the past decades; nevertheless, cancer survivors are burdened with multiple health complications primarily…”
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Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence by Abdelgawad, Ibrahim Y., Sadak, Karim T., Lone, Diana W., Dabour, Mohamed S., Niedernhofer, Laura J., Zordoky, Beshay N.

“…Cancer treatment has been associated with accelerated aging that can lead to early-onset health complications typically experienced by older populations. In…”
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Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in a Sex‐Dependent Manner by Agostinucci, Kevin, Grant, Marianne K. O., Melaku, Wongel, Abdelgawad, Ibrahim Y., Zordoky, Beshay N.

“…Introduction Subclinical cardiotoxicity occurs in cancer patients who receive low doses of anthracyclines such as doxorubicin (DOX), which can develop into…”
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Sex-related differences in delayed doxorubicin-induced cardiac dysfunction in C57BL/6 mice by Abdelgawad, Ibrahim Y., George, Benu, Grant, Marianne K. O., Huang, Yingbo, Shan, Yuting, Huang, R. Stephanie, Zordoky, Beshay N.

“…Cancer survivors may experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (DOX). The exact mechanism of delayed…”
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Abstract P3117: Cardiac Proteomics Analysis Reveals Sex-related Differences In Doxorubicin-induced Delayed Cardiotoxicity by Abdelgawad, Ibrahim Y, George, Benu, Grant, Marianne, Huang, Yingbo, Shan, Yuting, Huang, R. Stephanie, Zordoky, Beshay

“…Abstract only Introduction: Cancer survivors experience long-term cardiovascular complications due to chemotherapeutic drugs such as doxorubicin (DOX). Sex was…”
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Doxorubicin Cardiotoxicity in Young Tumor‐Bearing Mice by Abdelgawad, Ibrahim Y., Grant, Marianne K.O., Lewis, Christine, Popescu, Flavia, Largaespada, David, Zordoky, Beshay N.

“…Abstract only Background Childhood cancer survivors have about 15‐times higher risk of heart failure than their siblings mainly due to the cardiotoxicity of…”
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Abstract 1257: Early blood uMRD correlates with improved PFS in patients with CLL by Abdelgawad, Ibrahim Y., Suleiman, Ahmed A., Chyla, Brenda, Ghanim, Majd, Salem, Ahmed H., Badawi, Mohamed

“…Abstract The approval of targeted therapies has greatly improved outcomes for patients (pts) with chronic lymphocytic leukemia (CLL) in both 1L and…”
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