Search Results - "Abdelfadiel, Elsamani I."

A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation by Boothello, Rio S, Patel, Nirmita J, Sharon, Chetna, Abdelfadiel, Elsamani I, Morla, Shravan, Brophy, Donald F, Lippman, H Robert, Desai, Umesh R, Patel, Bhaumik B

“…Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated…”
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Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors by Abdelfadiel, Elsamani I., Gunta, Rama, Villuri, Bharath Kumar, Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Desai, Umesh R.

“…Natural glycosaminoglycans (GAGs) are arguably the most diverse collection of natural products. Unfortunately, this bounty of structures remains untapped…”
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Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity by Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

“…Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic…”
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A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding by Al‐Horani, Rami A., Abdelfadiel, Elsamani I., Afosah, Daniel K., Morla, Shravan, Sistla, Jyothi C., Mohammed, Bassem, Martin, Erika J., Sakagami, Masahiro, Brophy, Donald F., Desai, Umesh R.

“…Background Human factor XIa (FXIa) is an actively pursued target for development of safer anticoagulants. Our long‐standing hypothesis has been that…”
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518 - G2.2, a Unique Non-Sachharide Mimetic of Heparin Hexasaccharide Selectively Inhibits Cancerous but Protects Adult Colonic Stem/Progenitor Cells via a Common Mechanism of Induction of P38 Mitogen-Activated Protein Kinase by Boothello, Rio S., Patel, Nirmita, Sharon, Chetna, Karuturi, Rajesh, Abdelfadiel, Elsamani I., Morla, Shravan, Brophy, Donald F., Lippman, Robert, Desai, Umesh R., Patel, Bhaumik B.

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A Unique Non-Saccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation by Boothello, Rio S., Patel, Nirmita J., Sharon, Chetna, Abdelfadiel, Elsamani I., Morla, Shravan, Brophy, Donald F., Lippman, H Robert, Desai, Umesh R., Patel, Bhaumik B.

“…Targeting of cancer stem cells (CSCs) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated…”
Get full text