Search Results - "Abdelbary, Aly A"
-
1
Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation
Published in Drug delivery (2018)“…Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated…”
Get full text
Journal Article -
2
Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: Application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study
Published in International journal of pharmaceutics (15-05-2015)“…[Display omitted] Psoriasis, a skin disorder characterized by impaired epidermal differentiation, is regularly treated by systemic methotrexate (MTX), an…”
Get full text
Journal Article -
3
Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam
Published in International journal of pharmaceutics (15-05-2015)“…[Display omitted] Bilosomes represent an evolving vesicular carrier that have been explored for oral vaccines delivery based on its ability to resist enzymes…”
Get full text
Journal Article -
4
Fabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: In vitro characterization, ex vivo permeation and in vivo safety assessment
Published in International journal of pharmaceutics (20-11-2016)“…[Display omitted] The objective of this work was to encapsulate terconazole (TCZ), a water insoluble antifungal drug, into novel ultradeformable bilosomes…”
Get full text
Journal Article -
5
Norfloxacin loaded nano-cubosomes for enhanced management of otitis externa: In vitro and in vivo evaluation
Published in International journal of pharmaceutics (01-05-2021)“…[Display omitted] The research’s goal is to design and formulate nano-structured cubosomes loaded with norfloxacin (NFX)formanagement of otitis externa. In…”
Get full text
Journal Article -
6
Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein: in vitro characterization, ex vivo permeation and in vivo skin deposition study
Published in Journal of liposome research (02-01-2019)“…Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of…”
Get full text
Journal Article -
7
Fabrication of levofloxacin polyethylene glycol decorated nanoliposomes for enhanced management of acute otitis media: Statistical optimization, trans-tympanic permeation and in vivo evaluation
Published in International journal of pharmaceutics (25-03-2019)“…[Display omitted] Acute otitis media (AOM), an infection in the middle ear, is usually treated through systemic administration of antibiotics because the…”
Get full text
Journal Article -
8
Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation
Published in International journal of nanomedicine (01-01-2019)“…Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral bioavailability due to extensive first-pass metabolism. This study aimed to prepare…”
Get full text
Journal Article -
9
Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment
Published in International journal of nanomedicine (01-08-2019)“…The intention of this work was to load olmesartan medoxomil (OLM), a sparsely water soluble antihypertensive bioactive with low oral bioavailability (26%),…”
Get full text
Journal Article -
10
Instantaneous enteric nano-encapsulation of omeprazole: Pharmaceutical and pharmacological evaluation
Published in International journal of pharmaceutics (01-07-2014)“…[Display omitted] Recently, great attention has been paid to nanocapsules. The interest of these structures is due to their promising applications as drug…”
Get full text
Journal Article -
11
Effect of fixed aqueous layer thickness of polymeric stabilizers on zeta potential and stability of aripiprazole nanosuspensions
Published in Pharmaceutical development and technology (01-06-2013)“…The aim of this study was to evaluate the effect of the thickness of adsorbed polymer layer (also known as Fixed Aqueous Layer Thickness, FALT) of polymeric…”
Get full text
Journal Article -
12
Improved Targeting and Tumor Retention of a Newly Synthesized Antineoplaston A10 Derivative by Intratumoral Administration: Molecular Docking, Technetium 99m Radiolabeling, and In Vivo Biodistribution Studies
Published in Cancer biotherapy & radiopharmaceuticals (01-08-2018)“…Recently, the direct intratumoral (i.t.) injection of anticancer agents has been investigated. A newly synthesized Antineoplaston A10 analog…”
Get more information
Journal Article -
13
Design and development of microemulsion systems of a new antineoplaston A10 analog for enhanced intravenous antitumor activity: In vitro characterization, molecular docking, 125I-radiolabeling and in vivo biodistribution studies
Published in International journal of pharmaceutics (10-07-2018)“…[Display omitted] A10, (3-phenylacetylamino-2,6-piperidinedione), is a natural peptide with broad antineoplastic activity. Recently, in vitro antitumor effect…”
Get full text
Journal Article -
14
Preparation, optimization, and in vitro simulated inhalation delivery of carvedilol nanoparticles loaded on a coarse carrier intended for pulmonary administration
Published in International journal of nanomedicine (01-01-2015)“…Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A nanosuspension suitable for pulmonary delivery to enhance…”
Get full text
Journal Article -
15
Comparison of nanomilling and coprecipitation on the enhancement of in vitro dissolution rate of poorly water-soluble model drug aripiprazole
Published in Pharmaceutical development and technology (01-06-2014)“…Abstract The aim of this study was to evaluate the effect of coprecipitation and nanomilling on the crystallinity of a model drug, aripiprazole and evaluate…”
Get full text
Journal Article -
16
Design and development of microemulsion systems of a new antineoplaston A10 analog for enhanced intravenous antitumor activity: In vitro characterization, molecular docking, 125 I-radiolabeling and in vivo biodistribution studies
Published in International journal of pharmaceutics (04-05-2018)“…A10, (3-phenylacetylamino-2,6-piperidinedione), is a natural peptide with broad antineoplastic activity. Recently, in vitro antitumor effect of a new A10…”
Get full text
Journal Article