Is neuregulin-1 (NRG-1) a potential blood biomarker linking depression to obesity? A case-control study

Is neuregulin-1 (NRG-1) a potential blood biomarker linking depression to obesity? A case-control study

Abstract Background and aim No definite biomarker linking depression and obesity has been found yet. Our study aimed to investigate neuregulin-1 (NRG-1) as a potential blood biomarker for this association. Methods A case–control study was conducted on 108 obese subjects assigned for laparoscopic sle...

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Bibliographic Details
Published in:BMC psychiatry Vol. 23; no. 1; pp. 1 - 13
Main Authors: Abdelaziz, Heba Ahmed, Abdelbaki, Tamer Nabil, Dean, Yomna E, Assem, Sara
Format: Journal Article
Language:English
Published: London BioMed Central Ltd 14-09-2023
BioMed Central
BMC
Subjects:
Analysis
Biological markers
Biomarkers
Body mass index
Care and treatment
Chronic illnesses
Comorbidity
Complications and side effects
Depression
Depression, Mental
Diabetes
Diagnosis
Epidermal growth factor
Gastrectomy
Gastrointestinal surgery
Kinases
Laparoscopy
Mental depression
Neural circuitry
Neuregulin 1
Obesity
Overweight
Psychiatry
Psychological aspects
Questionnaires
Sample size
Surgery
Type 2 diabetes
Egypt
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Summary:Abstract Background and aim No definite biomarker linking depression and obesity has been found yet. Our study aimed to investigate neuregulin-1 (NRG-1) as a potential blood biomarker for this association. Methods A case–control study was conducted on 108 obese subjects assigned for laparoscopic sleeve gastrectomy and 100 non-obese controls. Depression was assessed pre- and post-operatively. Serum NRG-1 was measured. Results Pre-operatively depression was significantly higher among obese compared to non-obese patients. After the operation, 1.9% of the severely depressed subjects reported no depression, while 5.6% became moderately depressed; about 6% of the moderately depressed and 16% of the mildly depressed became not depressed. Serum NRG-1 level was significantly lower among obese and severely depressed compared to the controls. It was negatively correlated to the level of depression pre- and post-operative ( r  = -0.764 and -0.467 respectively). The sensitivity of serum NRG1 as a predictor for depression pre- and post-operative was 92.45% and 52.94% respectively. Specificity was 69.09% and 79.73% respectively at cut-off values of ≤ 3.5 and ≤ 2.5 ng/ml. Conclusion NRG-1 is a possible biomarker for the diagnosis of depression pre-bariatric surgery and the prediction of its prognosis post-operatively.
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ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-023-05160-6