Bacterial bug-out bags: outer membrane vesicles and their proteins and functions

Among the major bacterial secretions, outer membrane vesicles (OMVs) are significant and highly functional. The proteins and other biomolecules identified within OMVs provide new insights into the possible functions of OMVs in bacteria. OMVs are rich in proteins, nucleic acids, toxins and virulence...

Full description

Saved in:

Bibliographic Details
Published in:	The journal of microbiology Vol. 58; no. 7; pp. 531 - 542
Main Authors:	Dineshkumar, Kesavan, Aparna, Vasudevan, Wu, Liang, Wan, Jie, Abdelaziz, Mohamod Hamed, Su, Zhaoliang, Wang, Shengjun, Xu, Huaxi
Format:	Journal Article
Language:	English
Published:	Seoul The Microbiological Society of Korea 01-07-2020 Springer Nature B.V 한국미생물학회
Subjects:	Amino Acids - biosynthesis Bacteria Bacteria - metabolism Bacterial Outer Membrane Proteins - metabolism Bacterial vesicles Biomedical and Life Sciences Biomolecules Extracellular Vesicles - metabolism Humans Life Sciences Lipid Metabolism - physiology Membrane vesicles Membranes Microbiology Minireview Nucleic acids Nucleic Acids - biosynthesis Proteins Secretions Survival Toxins Vesicles Virulence Virulence Factors 생물학 bacterial defence mechanism outer membrane vesicles bacterial survival SOS mechanism moonlighting proteins
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Among the major bacterial secretions, outer membrane vesicles (OMVs) are significant and highly functional. The proteins and other biomolecules identified within OMVs provide new insights into the possible functions of OMVs in bacteria. OMVs are rich in proteins, nucleic acids, toxins and virulence factors that play a critical role in bacteria-host interactions. In this review, we discuss some proteins with multifunctional features from bacterial OMVs and their role involving the mechanisms of bacterial survival and defence. Proteins with moonlighting activities in OMVs are discussed based on their functions in bacteria. OMVs harbour many other proteins that are important, such as proteins involved in virulence, defence, and competition. Overall, OMVs are a power-packed aid for bacteria, harbouring many defensive and moonlighting proteins and acting as a survival kit in case of an emergency or as a defence weapon. In summary, OMVs can be defined as bug-out bags for bacterial defence and, therefore, survival.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1225-8873 1976-3794
DOI:	10.1007/s12275-020-0026-3