Search Results - "Abdelazeem, Ahmed H."

A Comprehensive Overview of Globally Approved JAK Inhibitors by Shawky, Ahmed M, Almalki, Faisal A, Abdalla, Ashraf N, Abdelazeem, Ahmed H, Gouda, Ahmed M

“…Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce…”
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Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance by Zha, Gao-Feng, Qin, Hua-Li, Youssif, Bahaa G.M., Amjad, Muhammad Wahab, Raja, Maria Abdul Ghafoor, Abdelazeem, Ahmed H., Bukhari, Syed Nasir Abbas

“…The drug research and development nowadays is focusing on multi-target drugs. In the treatment of cancer, therapies using drugs inhibiting one numerous targets…”
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Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Wasp Venom Biochemical Components and Their Potential in Biological Applications and Nanotechnological Interventions by Abd El-Wahed, Aida, Yosri, Nermeen, Sakr, Hanem H, Du, Ming, Algethami, Ahmed F M, Zhao, Chao, Abdelazeem, Ahmed H, Tahir, Haroon Elrasheid, Masry, Saad H D, Abdel-Daim, Mohamed M, Musharraf, Syed Ghulam, El-Garawani, Islam, Kai, Guoyin, Al Naggar, Yahya, Khalifa, Shaden A M, El-Seedi, Hesham R

“…Wasps, members of the order Hymenoptera, are distributed in different parts of the world, including Brazil, Thailand, Japan, Korea, and Argentina. The…”
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Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors by Al-Wahaibi, Lamya H., Youssif, Bahaa G. M., Taher, Ehab S., Abdelazeem, Ahmed H., Abdelhamid, Antar A., Marzouk, Adel A.

“…A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and…”
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Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities by El-Sherief, Hany A M, Youssif, Bahaa G M, Abdelazeem, Ahmed H, Abdel-Aziz, Mohamed, Abdel-Rahman, Hamdy M

“…1,2,4-triazoles possess a broad spectrum of biological activities such as analgesic, antimicrobial, antitubercular, anti-inflammatory and antineoplastic…”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda, Ahmed M., Abdelazeem, Ahmed H., Abdalla, Ashraf N., Ahmed, Muhammad

“…Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives ( and ) was prepared and evaluated for their…”
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Design, Synthesis, and Biological Evaluation of Some Novel Pyrrolizine Derivatives as COX Inhibitors with Anti-Inflammatory/Analgesic Activities and Low Ulcerogenic Liability by Gouda, Ahmed M, Ali, Hamed I, Almalki, Waleed H, Azim, Mohamed A, Abourehab, Mohammed A S, Abdelazeem, Ahmed H

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed anti-inflammatory and pain relief medications. However, their use is associated…”
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New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling by Abdelgawad, Mohamed A, Bukhari, Syed N. A, Musa, Arafa, Elmowafy, Mohammed, Elkomy, Mohammed H, Nayl, AbdElAziz. A, El-Ghorab, Ahmed H, Alsohaimi, Ibrahim Hotan, Abdel-Bakky, Mohamed Sadek, Althobaiti, Ibrahim O, Altaleb, Hamud A, Omar, Hany A, Abdelazeem, Ahmed H, Zaki, Mohamed A, Shaker, Mohamed E, Elshemy, Heba A. H

“…In this study new sulphamethoxazole derivatives (S1–S4, S6–S12, and S14–S22) were designed and synthesized and their structures were fully characterized and…”
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OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro by Arafa, El-shaimaa A, Abdelazeem, Ahmed H, Arab, Hany H, Omar, Hany A

“…Aim： Energy-restriction mimetic agents （ERMAs） are small-molecule agents that target various aspects of energy metabolism, which has emerged as a promising…”
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Study of the bone behavior around a neck preserving short stem implant: bone densitometric analysis over a span of two years by Shafy, Tarek Abdel, Sayed, Adel, Abdelazeem, Ahmed H

“…Study the bone mineral density (BMD) changes and the remodelling process after implantation of a neck preserving short stem implant over a period of two years…”
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Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors by El-Sherief, Hany A.M., Youssif, Bahaa G.M., Abbas Bukhari, Syed Nasir, Abdelazeem, Ahmed H., Abdel-Aziz, Mohamed, Abdel-Rahman, Hamdy M.

“…A series of novel compounds carrying 1,2,4-triazole scaffold were prepared and evaluated for their antiproliferative activities against NCI 60 cell line…”
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An integrated overview on pyrrolizines as potential anti-inflammatory, analgesic and antipyretic agents by Gouda, Ahmed M., Abdelazeem, Ahmed H.

“…Despite the existence of huge number of NSAIDs, the quest for safer drugs is still in the focus of several drug discovery programs. Pyrrolizine heterocyclic…”
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Reduction of Posterior Column in Displaced Acetabular Fractures Using Bone Holding Forceps by Fahmy, Mahmoud, Abdelazeem, Ahmed H.

“…Reduction of the posterior column in displaced acetabular fracture anatomically is challenging and depends on good reduction tools application. Many reduction…”
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Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity by Mohamed, Fatma A.M., Gomaa, Hesham A.M., Hendawy, O.M., Ali, Asmaa T., Farghaly, Hatem S., Gouda, Ahmed M., Abdelazeem, Ahmed H., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G.M.

“…[Display omitted] •A series of novel indole-2-carboxmide derivatives 9–23 as EGFR inhibitors has been designed and synthesized.•Compounds 10, 11, 13, 15 and…”
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Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks by Abdelazeem, Ahmed H., Safi El-Din, Asmaa G., Abdel-Fattah, Maha M., Amin, Noha H., El-Moghazy, Samir M., El-Saadi, Mohammed T.

“…Herein we describe our efforts to develop novel anti-inflammatory/analgesic agents devoid of known cardiovascular drawbacks. In doing so, two…”
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Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities by Abdelatef, Shaimaa A., El-Saadi, Mohammed T., Amin, Noha H., Abdelazeem, Ahmed H., Omar, Hany A., Abdellatif, Khaled R.A.

“…A novel series of spirobenzo[h]chromene and spirochromane derivatives was designed, synthesized and evaluated as potential anticancer agents against MCF-7…”
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Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity by Abdelrahman, Mostafa H., Youssif, Bahaa G.M., abdelgawad, Mohamed A., Abdelazeem, Ahmed H., Ibrahim, Hussein M., Moustafa, Abd El Ghany A., Treamblu, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel quinoline-2-carboxamides 15–28 was synthesized and evaluated in vitro as dual COXs/LOX inhibitors. Compounds 19 and 27 exhibited the highest…”
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What Is the Most Optimal Bearing Surface for Minimizing Instability After Revision Total Hip Arthroplasty? by Tarabichi, Saad, Verhey, Jens T., Vink, Marije C., Peters, Rinne M., Elkabbani, Mohamed, Abdelazeem, Ahmed H., Petheram, Timothy, Valpiana, Pieralberto, Jordaan, JD, Alazzawi, Sulaiman, Xian-Zhe, Liu, Spangehl, Mark J., Zijlstra, Wierd P., Bingham, Joshua S.

“…Based on the results of our meta-analysis, dual mobility implants appear to have the most efficacy in preventing instability following revision total hip…”
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Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions by Shawky, Ahmed M., Almalki, Faisal A., Alzahrani, Hayat Ali, Abdalla, Ashraf N., Youssif, Bahaa G.M., Ibrahim, Nashwa A., Gamal, Mohammed, El-Sherief, Hany A.M., Abdel-Fattah, Maha M., Hefny, Ahmed A., Abdelazeem, Ahmed H., Gouda, Ahmed M.

“…Since 2020, many compounds have been investigated for their potential use in the treatment of SARS-CoV-2 infection. Among these agents, a huge number of…”
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