Search Results - "AbdelMalek, F."

Nonalcoholic fatty liver disease: another leap forward by Abdelmalek, Manal F.

“…In 2020, there have been substantial advances in nonalcoholic fatty liver disease mechanisms, diagnostics and treatment. Key developments include the…”
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AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease by Rinella, Mary E, Neuschwander-Tetri, Brent A, Siddiqui, Mohammad Shadab, Abdelmalek, Manal F, Caldwell, Stephen, Barb, Diana, Kleiner, David E, Loomba, Rohit

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Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps by Lonardo, Amedeo, Nascimbeni, Fabio, Ballestri, Stefano, Fairweather, DeLisa, Win, Sanda, Than, Tin A., Abdelmalek, Manal F., Suzuki, Ayako

“…Despite tremendous research advancements in nonalcoholic fatty liver disease (NAFLD), our understanding of sex differences in NAFLD remains insufficient. This…”
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Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors by Francque, Sven, Szabo, Gyongyi, Abdelmalek, Manal F., Byrne, Christopher D., Cusi, Kenneth, Dufour, Jean-François, Roden, Michael, Sacks, Frank, Tacke, Frank

“…The increasing epidemic of obesity worldwide is linked to serious health effects, including increased prevalence of type 2 diabetes mellitus, cardiovascular…”
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Fructose and sugar: A major mediator of non-alcoholic fatty liver disease by Jensen, Thomas, Abdelmalek, Manal F., Sullivan, Shelby, Nadeau, Kristen J., Green, Melanie, Roncal, Carlos, Nakagawa, Takahiko, Kuwabara, Masanari, Sato, Yuka, Kang, Duk-Hee, Tolan, Dean R., Sanchez-Lozada, Laura G., Rosen, Hugo R., Lanaspa, Miguel A., Diehl, Anna Mae, Johnson, Richard J.

“…Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes…”
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ACE inhibitors: The secret to prevent cirrhosis complications and HCC in NAFLD? by Noureddin, Mazen, Abdelmalek, Manal F.

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The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials by Sanyal, Arun J., Harrison, Stephen A., Ratziu, Vlad, Abdelmalek, Manal F., Diehl, Anna Mae, Caldwell, Stephen, Shiffman, Mitchell L., Aguilar Schall, Raul, Jia, Catherine, McColgan, Bryan, Djedjos, C. Stephen, McHutchison, John G., Subramanian, G. Mani, Myers, Robert P., Younossi, Zobair, Muir, Andrew J., Afdhal, Nezam H., Bosch, Jaime, Goodman, Zachary

“…Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized. We analyzed data on longitudinal changes in liver histology, hepatic venous…”
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Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis by Younossi, Zobair M., Loomba, Rohit, Anstee, Quentin M., Rinella, Mary E., Bugianesi, Elisabetta, Marchesini, Giulio, Neuschwander‐Tetri, Brent A., Serfaty, Lawrence, Negro, Francesco, Caldwell, Stephen H., Ratziu, Vlad, Corey, Kathleen E., Friedman, Scott L., Abdelmalek, Manal F., Harrison, Stephen A., Sanyal, Arun J., Lavine, Joel E., Mathurin, Philippe, Charlton, Michael R., Goodman, Zachary D., Chalasani, Naga P., Kowdley, Kris V., George, Jacob, Lindor, Keith

“…Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis, nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis…”
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Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by Younossi, Zobair M., Loomba, Rohit, Rinella, Mary E., Bugianesi, Elisabetta, Marchesini, Giulio, Neuschwander‐Tetri, Brent A., Serfaty, Lawrence, Negro, Francesco, Caldwell, Stephen H., Ratziu, Vlad, Corey, Kathleen E., Friedman, Scott L., Abdelmalek, Manal F., Harrison, Stephen A., Sanyal, Arun J., Lavine, Joel E., Mathurin, Philippe, Charlton, Michael R., Chalasani, Naga P., Anstee, Quentin M., Kowdley, Kris V., George, Jacob, Goodman, Zachary D., Lindor, Keith

“…Nonalcoholic fatty liver disease (NAFLD) and its progressive form non‐alcoholic steatohepatitis (NASH), are rapidly becoming among the top causes of cirrhosis,…”
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Metamaterial Superlenses Operating at Visible Wavelength for Imaging Applications by Haxha, S., AbdelMalek, F., Ouerghi, F., Charlton, M. D. B., Aggoun, A., Fang, X.

“…In this paper, a novel design for a metamaterial lens (superlens) based on a Photonic Crystal (PC) operating at visible wavelengths is reported. The proposed…”
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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial by Neuschwander-Tetri, Brent A, Prof, Loomba, Rohit, MD, Sanyal, Arun J, Prof, Lavine, Joel E, Prof, Van Natta, Mark L, MHS, Abdelmalek, Manal F, MD, Chalasani, Naga, Prof, Dasarathy, Srinivasan, MD, Diehl, Anna Mae, Prof, Hameed, Bilal, MD, Kowdley, Kris V, Prof, McCullough, Arthur, Prof, Terrault, Norah, Prof, Clark, Jeanne M, Prof, Tonascia, James, Prof, Brunt, Elizabeth M, Prof, Kleiner, David E, MD, Doo, Edward, MD

“…Summary Background The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that…”
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A randomised, double-blind, placebo-controlled, multi-centre, dose-range, proof-of-concept, 24-week treatment study of lanifibranor in adult subjects with non-alcoholic steatohepatitis: Design of the NATIVE study by Sven M., Francque, Pierre, Bedossa, Manal F., Abdelmalek, Quentin M., Anstee, Elisabetta, Bugianesi, Vlad, Ratziu, Philippe, Huot-Marchand, Bruno, Scherrer, Jean-Louis, Junien, Pierre, Broqua, Jean-Louis, Abitbol

“…Background Non-alcoholic steatohepatitis (NASH), a multifactorial disease, can progress to hepatic fibrosis and cirrhosis. The Peroxysomal…”
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Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease by Alexopoulos, Anastasia‐Stefania, Crowley, Matthew J., Wang, Ying, Moylan, Cynthia A., Guy, Cynthia D., Henao, Ricardo, Piercy, Dawn L., Seymour, Keri A., Sudan, Ranjan, Portenier, Dana D., Diehl, Anna Mae, Coviello, Andrea D., Abdelmalek, Manal F.

“…Background and Aims Whether glycemic control, as opposed to diabetes status, is associated with the severity of NAFLD is open for study. We aimed to evaluate…”
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Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science by Siddiqui, Mohammad Shadab, Harrison, Stephen A., Abdelmalek, Manal F., Anstee, Quentin M., Bedossa, Pierre, Castera, Laurent, Dimick‐Santos, Lara, Friedman, Scott L., Greene, Katherine, Kleiner, David E., Megnien, Sophie, Neuschwander‐Tetri, Brent A., Ratziu, Vlad, Schabel, Elmer, Miller, Veronica, Sanyal, Arun J.

“…Nonalcoholic steatohepatitis (NASH) is an important cause of liver‐related morbidity and mortality. There are no approved therapies, and the results of…”
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A Novel Birefrigent Photonic Crystal Fiber Surface Plasmon Resonance Biosensor by Otupiri, R., Akowuah, E. K., Haxha, S., Ademgil, H., AbdelMalek, F., Aggoun, A.

“…A numerical analysis of a novel birefringent photonic crystal fiber (PCF) biosensor constructed on the surface plasmon resonance (SPR) model is presented in…”
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Fructose consumption as a risk factor for non-alcoholic fatty liver disease by Ouyang, Xiaosen, Cirillo, Pietro, Sautin, Yuri, McCall, Shannon, Bruchette, James L, Diehl, Anna Mae, Johnson, Richard J, Abdelmalek, Manal F

“…Background/Aims While the rise in non-alcoholic fatty liver disease (NAFLD) parallels the increase in obesity and diabetes, a significant increase in dietary…”
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Tackling Nonalcoholic Fatty Liver Disease: Three Targeted Populations by Wegermann, Kara, Suzuki, Ayako, Mavis, Alisha M., Abdelmalek, Manal F., Diehl, Anna Mae, Moylan, Cynthia A.

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Design of a Novel Left-Handed Photonic Crystal Sensor Operating in Aqueous Environment by AbdelMalek, F

“…In this letter, we theoretically propose a biosensor based on a two-dimensional left-handed photonic crystal coupled to an M-shaped resonator. The sensor is…”
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Eco-friendly perovskite/CZTSSe tandem cell exceeding 28% efficiency through current matching and bandgap optimization: a numerical investigation by Maoucha, A., Djeffal, F., Ferhati, H., AbdelMalek, F.

“…Tandem solar cells are capable of dividing the solar spectrum over multiple sub-cells with distinct bandgaps, leading to enhanced conversion efficiencies…”
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Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease by Guy, Cynthia D., Suzuki, Ayako, Zdanowicz, Marzena, Abdelmalek, Manal F., Burchette, James, Unalp, Aynur, Diehl, Anna Mae

“…The Hedgehog (HH)‐signaling pathway mediates several processes that are deregulated in patients with metabolic syndrome (e.g., fat mass regulation,…”
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