Taxonomic Characterizations of Soil Streptomyces cavourensis DW102 and Its Activity against Fungal Pathogens

spp. are soil bacteria that have commercial value from which numerous secondary metabolites such as antifungal compounds have been derived. There is growing concern that antifungal resistance is on the rise, and soil from various geographical places might produce novel antifungal molecules. The aim...

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Bibliographic Details
Published in:	Journal of pharmacy & bioallied science Vol. 12; no. 4; pp. 462 - 467
Main Authors:	Sheik, Gouse Basha, Alhumaidy, Aroob Abdullah, Abdel Raheim, Ali Ismail Ali, Alzeyadi, Zeyad Abdullah, AlGhonaim, Mohammed Ibrahim
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-10-2020 Wolters Kluwer - Medknow
Subjects:	Antifungal agents Drug resistance in microorganisms Ethylenediaminetetraacetic acid Original Pathogenic microorganisms Physiological aspects Plant metabolites Saudi Arabia Niger Candida albicans antifungal 16s rRNA Aspergillus niger Streptomyces cavourensis
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Summary:	spp. are soil bacteria that have commercial value from which numerous secondary metabolites such as antifungal compounds have been derived. There is growing concern that antifungal resistance is on the rise, and soil from various geographical places might produce novel antifungal molecules. The aim of this study was to characterize and identify the actinomycetes strain namely isolate DW102, and to evaluate its antimicrobial activity against nosocomial fungal pathogens. isolate DW102 was identified based on morphological, cultural, physiological, and biochemical properties, together with 16S rRNA sequence. Its antifungal activity was determined by agar well-diffusion assays. The isolate DW102 phenotypic and molecular characterization was identified as DW102 and sequencing results were deposited in GenBank under accession number MK508855. Furthermore, the fermented broth of isolate DW102 inhibited the growth of and . Phenotypic, molecular, and phylogenetic analysis of DW102 identified the strain to be . The antifungal assay showed that DW102 fermentation broth was active against both and . Further studies are required to use the isolate DW102 as a promising source for the development of antifungal drugs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0976-4879 0975-7406 0975-7406
DOI:	10.4103/jpbs.JPBS_304_20