Beyond clinical trials: real-world impact of immunotherapy on NSCLC in Jordan

This study aims to evaluate real-world (rw) outcomes of immunotherapy (IO) for advanced stage NSCLC at King Hussein Cancer Center (KHCC) in Jordan. Advanced stage NSCLC patients who received IO at KHCC between 2017 and 2022 were included. The data were retrospectively collected. PFS and OS were esti...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in oncology Vol. 14; p. 1369126
Main Authors:	Abu Hejleh, Taher, AlSawalha, Karim, Abdel Hafiz, Sufian, Al-Batsh, Tamer, Abu Hejleh, Roaa, Yaser, Sameer, Abu Jazar, Husam, Khader, Jamal, Alnsour, Anoud, Mohamad, Issa, Abdel Jalil, Riad, Abu-Shanab, Ahmad, Gharaibeh, Azza, Abu Shattal, Mohammad, Alibraheem, Akram, Haddad, Hussam, Mahmoud, Naser, Obeidat, Shadi, Al-Jaghbeer, Mohammed J, Furqan, Muhammad, Cortellini, Alessio, Velcheti, Vamsidhar, Al-Rabi, Kamal
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 30-04-2024
Subjects:	immunotherapy Jordan KHCC NSCLC Oncology real-world real-world NSCLC Jordan KHCC immunotherapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study aims to evaluate real-world (rw) outcomes of immunotherapy (IO) for advanced stage NSCLC at King Hussein Cancer Center (KHCC) in Jordan. Advanced stage NSCLC patients who received IO at KHCC between 2017 and 2022 were included. The data were retrospectively collected. PFS and OS were estimated for patients with ECOG performance status (ECOG PS) 0-1. Cox regression analyzed predictors of OS in first-line (1L) IO, regardless of performance status. The total number of patients included was 244. Out of those, 160 (65%), 67 (28%), and 17 (7%) patients received IO as 1L, second-line (2L), or third-line or beyond (3L or beyond), respectively. The median age for all patients was 59 years. Male were 88%, and 77% were smokers. The median follow-up time was 12.5 months. The median PFS and OS for 1L IO were 7 [95% CI 5.8 - 10.3] and 11.8 [95% CI 8.8 - 14.4], months, respectively. In the first 3 months after starting 1L IO, 34/160 (21%) patients had died. For those who survived beyond 3 months after starting 1L IO, the median PFS and OS were 11.3 [95% CI 8.3 - 16.5] and 15.4 [95% CI 13.2 - 21] months, respectively. In the Cox regression model of 1L IO patients with any performance status, ECOG PS 2 was predictive of worse OS compared to ECOG PS 0-1 ( = 0.005). This real-world study of advanced-stage NSCLC patients treated with immunotherapy at KHCC reveals outcomes that fall short of those anticipated from clinical trials. The inclusion of Middle Eastern patients in lung cancer trials is essential to ensure adequate representation of various ethnicities in clinical research.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Andrea Camerini, Azienda Usl Toscana Nord Ovest, Italy Reviewed by: Magdalena Knetki-Wróblewska, Maria Sklodowska-Curie National Research Institute of Oncology, Poland Teodora Alexa-Stratulat, Grigore T. Popa University of Medicine and Pharmacy, Romania
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2024.1369126