Search Results - "Abdel Fattah Ezzat, Manal"

Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone-based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease by Ezzat, Manal Abdel Fattah, Abdelhamid, Sara Mohamed, Fouad, Marwa A, Abdel-Aziz, Hatem A, Allam, Heba Abdelrasheed

“…Twenty novel phthalazinone-based compounds were designed as acetylcholinesterase (hAChE) inhibitors. Compounds 7e and 17c demonstrated comparable or superior…”
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Synthesis and characterization of new tetrakisphosphonic acid derivatives as FPPS inhibitors and evaluation of their anti-osteoclastogenic potential for prevention of osteoporosis by Hassan, A. M. A., El-Hussieny, Marwa, El-Sayed, Naglaa F., Fouad, Marwa A., Ewies, Ewies F., Ezzat, Manal Abdel Fattah

“…Numerous bone illnesses, including osteoporosis, are brought on by abnormal osteoclast differentiation. The identification of effective strategies for…”
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Synthesis of S-alkylated oxadiazole bearing imidazo[2,1-b]thiazole derivatives targeting breast cancer: In vitro cytotoxic evaluation and in vivo radioactive tracing studies by Mohammed, Eman R., Abdel Fattah Ezzat, Manal, Seif, Emad M., Essa, Basma M., Abdel-Aziz, Hatem A., Sakr, Tamer M., Ibrahim, Hany S.

“…[Display omitted] •Two series of oxadiazole bearing imidazo[2,1-b]thiazole derivatives were synthesized and screened by NCI.•IC50 values for the compounds 3b,…”
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Synthesis of S-alkylated oxadiazole bearing imidazo2,1-bthiazole derivatives targeting breast cancer: In vitro cytotoxic evaluation and in vivo radioactive tracing studies by Mohammed, Eman R, Abdel Fattah Ezzat, Manal, Seif, Emad M, Essa, Basma M, Abdel-Aziz, Hatem A, Sakr, Tamer M, Ibrahim, Hany S

“…Breast cancer is the most common invasive cancer diagnosed in women, accounting for most cancer-related fatalities globally. Numerous investigations have…”
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Design, synthesis, and biological evaluation of furan‐bearing pyrazolopyridines as novel inhibitors of CDK2 and P53–MDM2 protein–protein interaction by Manal Abdel Fattah Ezzat, Elmasry, Ghada F, Menna M A Abd El‐Mageed, Fouad, Marwa A, Hatem A Abdel‐Aziz, Elewa, Safaa I

“…The novel series of furan‐bearing pyrazolo[3,4‐b]pyridines were designed as cyclin‐dependent kinase 2 (CDK2) inhibitors and as p53–murine double minute 2…”
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Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents by El-Sayed, Nehad Abou-Elmagd, Farag, Awatef El-Said, Ezzat, Manal Abdel Fattah, Akincioglu, Hulya, Gülçin, İlhami, Abou-Seri, Sahar Mahmoud

“…[Display omitted] •New pyrrolizine derivatives were synthesized as potential anti-Alzheimer's agents.•Compounds 10 and 11 had the highest AChE inhibitory…”
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Discovery of novel quinolin-2-one derivatives as potential GSK-3β inhibitors for treatment of Alzheimer’s disease: Pharmacophore-based design, preliminary SAR, in vitro and in vivo biological evaluation by Abdo Moustafa, Esraa, Abdelrasheed Allam, Heba, Fouad, Marwa A., El Kerdawy, Ahmed M., Nasser Eid El-Sayed, Nahed, Wagner, Christoph, Abdel-Aziz, Hatem A., Abdel Fattah Ezzat, Manal

“…[Display omitted] •New quinolin-2-one derivatives were synthesized as potential anti-Alzheimer's agents.•Compounds 7c, 7e and 7f had the highest GSK-3β…”
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Design, synthesis, and biological evaluation of furan-bearing pyrazolo[3,4-b]pyridines as novel inhibitors of CDK2 and P53-MDM2 protein-protein interaction by Ezzat, Manal Abdel Fattah, Elmasry, Ghada F, El-Mageed, Menna M A Abd, Fouad, Marwa A, Abdel-Aziz, Hatem A, Elewa, Safaa I

“…The novel series of furan-bearing pyrazolo[3,4-b]pyridines were designed as cyclin-dependent kinase 2 (CDK2) inhibitors and as p53-murine double minute…”
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