Search Results - "Abdel‐Wahab, Zeinab"

Optimizing a Novel Regional Chemotherapeutic Agent against Melanoma: Hyperthermia-Induced Enhancement of Temozolomide Cytotoxicity by SAE HEE KO, UENO, Tomio, TYLER, Douglas S, YOSHIMOTO, Yasunori, JIN SOO YOO, ABDEL-WAHAB, Omar I, ABDEL-WAHAB, Zeinab, CHU, Edward, PRUITT, Scott K, FRIEDMAN, Henry S, DEWHIRST, Mark W

“…Purpose: Previous preclinical studies have shown that regional temozolomide therapy via isolated limb infusion is more effective than melphalan, the current…”
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Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer by Grubbs, Elizabeth G, Abdel-Wahab, Zeinab, Tyler, Douglas S, Pruitt, Scott K

“…Real-time quantitative polymerase chain reaction (qPCR) may prove to be a sensitive technique by which to evaluate potential tumor markers in pancreatic…”
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Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine by Ueno, Tomio, Ko, Sae Hee, Grubbs, Elizabeth, Yoshimoto, Yasunori, Augustine, Christi, Abdel-Wahab, Zeinab, Cheng, Tsung-Yen, Abdel-Wahab, Omar I, Pruitt, Scott K, Friedman, Henry S, Tyler, Douglas S

“…This study investigated whether the therapeutic index of regional melanoma therapy using parenteral temozolomide could be improved by chemomodulation with O 6…”
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Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice by De Matos, Pierre, Abdel-Wahab, Zeinab, Vervaert, Carol, Hester, Dina, Seigler, Hilliard

“…Background and Objectives: Dendritic cells (DC) pulsed in vitro with a variety of antigens have proved effective in producing specific antitumor effects in…”
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MCA106 fibrosarcoma cells transduced with granulocyte/macrophage colony-stimulating factor are not superior to the wild-type cells in suppressing the growth of hepatic metastases by Dong, Xiang Da, Abdel-Wahab, Zeinab, Dematos, Pierre, Fong, Timothy, Pruitt, Scott K., Seigler, Hilliard F.

“…Background and Objectives Vaccination with cytokine gene‐modified tumor cells augments the immune response against established tumors and protects against…”
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Induction of Human Dendritic Cell Maturation Using Transfection with RNA Encoding a Dominant Positive Toll-Like Receptor 4 by Cisco, Robin M, Abdel-Wahab, Zeinab, Dannull, Jens, Nair, Smita, Tyler, Douglas S, Gilboa, Eli, Vieweg, Johannes, Daaka, Yehia, Pruitt, Scott K

“…Maturation of dendritic cells (DC) is critical for the induction of Ag-specific immunity. Ag-loaded DC matured with LPS, which mediates its effects by binding…”
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Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O 6-benzylguanine by Ueno, Tomio, Ko, Sae Hee, Grubbs, Elizabeth, Yoshimoto, Yasunori, Augustine, Christi, Abdel-Wahab, Zeinab, Cheng, Tsung-Yen, Abdel-Wahab, Omar I., Pruitt, Scott K., Friedman, Henry S., Tyler, Douglas S.

“…This study investigated whether the therapeutic index of regional melanoma therapy using parenteral temozolomide could be improved by chemomodulation with…”
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A Phase I clinical trial of immunotherapy with interferon-γ gene-modified autologous melanoma cells : Monitoring the humoral immune response by ABDEL-WAHAB, Z, WELTZ, C, HESTER, D, PICKETT, N, VERVAERT, C, BARBER, J. R, JOLLY, D, SEIGLER, H. F

“…Tumor cells transduced with cytokine genes provide immunogenic vaccines for cancer immunotherapy. A Phase I clinical trial was conducted for the specific…”
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Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses by Abdel-Wahab, Zeinab, Cisco, Robin, Dannull, Jens, Ueno, Tomio, Abdel-Wahab, Omar, Kalady, Matthew F., Onaitis, Mark W., Tyler, Douglas S., Pruitt, Scott K.

“…Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC. Immature DC were cotransfected…”
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In-transit melanoma: The role of alkylating-agent resistance in regional therapy by Grubbs, Elizabeth G., Abdel-Wahab, Omar, Cheng, Tsung-Yen, Abdel-Wahab, Zeinab, Peterson, Bercedis, Pruitt, Scott K., Colvin, O.Michael, Friedman, Henry S., Tyler, Douglas S.

“…Regional perfusion treatments for melanoma, using the alkylating agent melphalan, show variable responses in magnitude and duration. Surprisingly, the…”
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Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity by Kalady, Matthew F, Onaitis, Mark W, Emani, Sirisha, Abdel-Wahab, Zeinab, Tyler, Douglas S, Pruitt, Scott K

“…Despite the increasing use of dendritic cells (DCs) in clinical trials, questions regarding the optimal means of DC preparation, in particular how to achieve…”
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In-transit melanoma: The role of alkylating-agent resistance in regional therapy1 by Grubbs, Elizabeth G., Abdel-Wahab, Omar, Cheng, Tsung-Yen, Abdel-Wahab, Zeinab, Peterson, Bercedis, Pruitt, Scott K., Colvin, Michael O., Friedman, Henry S., Tyler, Douglas S.

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CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy by Onaitis, Mark W., Kalady, Matthew F., Emani, Sirisha, Abdel-Wahab, Zeinab, Tyler, Douglas S., Pruitt, Scott K.

“…Background. Dendritic cell (DC)-based immunotherapy is a promising form of adjuvant therapy for high-risk tumors. DCs transfected with tumor-associated…”
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Vaccination with Dendritic Cells Inhibits the Growth of Hepatic Metastases in B6 Mice by DeMatos, Pierre, Abdel-Wahab, Zeinab, Vervaert, Carol, Seigler, Hilliard F.

“…Dendritic cells (DC) are specialized antigen-presenting cells that can activate naive and mature T-cells, induce cellular immunity, and stimulate strong…”
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Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution by Abdel-Wahab, Zeinab, Kalady, Matthew F., Emani, Sirisha, Onaitis, Mark W., Abdel-Wahab, Omar I., Cisco, Robin, Wheless, Lee, Cheng, Tsung-Yen, Tyler, Douglas S., Pruitt, Scott K.

“…Modification of the parental immunodominant Melan-A/MART-1 peptide (MART-1 26–35) by replacing the alanine with leucine (A27L) enhances its immunogenicity…”
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Human Dendritic Cells, Pulsed with either Melanoma Tumor Cell Lysates or the gp100 Peptide(280-288), Induce Pairs of T-Cell Cultures with Similar Phenotype and Lytic Activity by Abdel-Wahab, Zeinab, DeMatos, Pierre, Hester, Dina, Dong, Xiang Da, Seigler, Hilliard F.

“…Dendritic cells (DCs) pulsed with unfractionated tumor cell lysates or defined tumor peptides provide potent vaccines which elicit strong antitumor immunity…”
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Generation of Melanoma-Specific, Cytotoxic CD4+ T Helper 2 Cells: Requirement of both HLA-DR15 and Fas Antigens on Melanomas for Their Lysis by Th2 Cells by Zennadi, Rahima, Abdel-Wahab, Zeinab, Seigler, Hilliard F., Darrow, Timothy L.

“…Recognition of melanoma antigens by HLA class-II-restricted CD4+ T lymphocytes has been investigated. Two cytotoxic CD4+ T cell lines were established by…”
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Effect of Irradiation on Cytokine Production, MHC Antigen Expression, and Vaccine Potential of Interleukin-2 and Interferon-γ Gene-Modified Melanoma Cells by Abdel-Wahab, Zeinab, Dar, Mohammed M., Hester, Dina, Vervaert, Carol, Gangavalli, Ramarao, Barber, Jack, Darrow, Timothy L., Seigler, Hilliard F.

“…Recent studies have shown that tumor cells transduced with interleukin-2 (IL-2) or interferon-γ (IFN-γ) genes stimulated a potent and specific antitumor…”
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A phase I clinical trial of immunotherapy with interferon‐γ gene‐modified autologous melanoma cells by Abdel‐Wahab, Zeinab, Weltz, Christina, Hester, Dina, Pickett, Nancy, Vervaert, Carol, Barber, Jack R., Jolly, Douglas, Seigler, Hilliard F.

“…BACKGROUND Tumor cells transduced with cytokine genes provide immunogenic vaccines for cancer immunotherapy. METHODS A Phase I clinical trial was conducted for…”
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A phase I clinical trial of immunotherapy with interferon-? gene-modified autologous melanoma cells: Monitoring the humoral immune response by Abdel-Wahab, Zeinab, Weltz, Christina, Hester, Dina, Pickett, Nancy, Vervaert, Carol, Barber, Jack R., Jolly, Douglas, Seigler, Hilliard F.

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