Search Results - "Abdel‐Malek, Z. A."

Journey through the spectacular landscape of melanocortin 1 receptor by Upadhyay, P. R., Swope, V. B., Starner, R. J., Koikov, L., Abdel‐Malek, Z. A.

“…The physiological role of α‐melanocyte stimulating hormone in regulating integumental pigmentation of many vertebrate species has been recognized since the…”
Get full text

Cellular senescence in naevi and immortalisation in melanoma: a role for p16? by GRAY-SCHOPFER, V. C, CHEONG, S. C, CHONG, H, CHOW, J, MOSS, T, ABDEL-MALEK, Z. A, MARAIS, R, WYNFORD-THOMAS, D, BENNETT, D. C

“…Cellular senescence, the irreversible proliferative arrest seen in somatic cells after a limited number of divisions, is considered a crucial barrier to…”
Get full text

Melanocortin receptors: their functions and regulation by physiological agonists and antagonists by Abdel-Malek, Z A

“…The melanocortins are a family of bioactive peptides derived from proopiomelanocortin, and share significant structural similarity. Those peptides are best…”
Get full text

Activation of the cyclic AMP pathway by α-melanotropin mediates the response of human melanocytes to ultraviolet B radiation by IM, S, MORO, O, PENG, F, MEDRANO, E. E, CORNELIUS, J, BABCOCK, G, NORDLUND, J. J, ABDEL-MALEK, Z. A

“…A hallmark of sun exposure is increased melanin synthesis by cutaneous melanocytes which protects against photodamage and photocarcinogenesis. Irradiation of…”
Get full text

MC1R and the response of melanocytes to ultraviolet radiation by Rouzaud, Francois, Kadekaro, Ana Luisa, Abdel-Malek, Zalfa A, Hearing, Vincent J

“…The constitutive color of our skin plays a dramatic role in our photoprotection from solar ultraviolet radiation (UVR) that reaches the Earth and in minimizing…”
Get full text

Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis by Suzuki, I, Cone, R D, Im, S, Nordlund, J, Abdel-Malek, Z A

“…alpha-Melanocyte stimulating hormone (alpha-MSH) and ACTH increase the proliferation and melanogenesis of cultured human melanocytes. To further analyze how…”
Get full text

Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation by Scott, M Cathy, Wakamatsu, Kazumasa, Ito, Shosuke, Kadekaro, Ana Luisa, Kobayashi, Nobuhiko, Groden, Joanna, Kavanagh, Renny, Takakuwa, Takako, Virador, Victoria, Hearing, Vincent J, Abdel-Malek, Zalfa A

“…Cutaneous pigmentation is determined by the amounts of eumelanin and pheomelanin synthesized by epidermal melanocytes and is known to protect against…”
Get full text

Agouti Signaling Protein Inhibits Melanogenesis and the Response of Human Melanocytes to α-Melanotropin by Suzuki, Itaru, Tada, Akihiro, Ollmann, Michael M., Barsh, Gregory S., Im, Sungbin, Lynn Lamoreux, M., Hearing, Vincent J., Nordlund, James J., Abdel-Malek, Zalfa A.

“…In mouse follicular melanocytes, the switch between eumelanin and pheomelanin synthesis is regulated by the extension locus, which encodes the melanocortin-1…”
Get full text

Endothelin stimulates chloride secretion across canine tracheal epithelium by Plews, P I, Abdel-Malek, Z A, Doupnik, C A, Leikauf, G D

“…The endothelins (ET) are a group of isopeptides produced by a number of cells, including canine tracheal epithelial cells. Because these compounds are…”
Get full text

Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21waf-1/SDI-1/Cip-1 protein by MEDRANO, E. E, SUNGBIN IM, FAN YANG, ABDEL-MALEK, Z. A

“…UVB irradiation inhibits melanocyte proliferation by causing arrest in G1 (D. Barker, K. Dixon, E. E. Medrano, D. Smalara, S. Im, D. Mitchell, G. Babcock, and…”
Get full text

Endocrine factors as effectors of integumental pigmentation by Abdel-Malek, Z A

“…Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen,…”
Get more information

The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes by Abdel-Malek, Z A, Scott, M C, Furumura, M, Lamoreux, M L, Ollmann, M, Barsh, G S, Hearing, V J

“…The agouti gene codes for agouti signaling protein (ASP), which is temporally expressed in wild-type mouse follicular melanocytes where it induces pheomelanin…”
Get full text

A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function by Swope, VB, Abdel-Malek, ZA, Sauder, DN, Nordlund, JJ

“…It is known that many immunologic responses to IL-1 are antagonized by the neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH). This led us to…”
Get full text

Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation by TADA, A, SUZUKI, I, SUNGBIN IM, DAVIS, M. B, CORNELIUS, J, BABCOCK, G, NORDLUND, J. J, ABDEL-MALEK, Z. A

“…Endothelin (ET)-1, alpha-melanocyte stimulating hormone (alpha-melanotropin; alpha-MSH), and basic fibroblast growth factor (bFGF) are keratinocyte-derived…”
Get full text

Synthesis of Interleukin-1α and β by Normal Human Melanocytes by Swope, Viki B, Krug, Kimberly A, Nordlund, James J, Abdel-Malek, Zalfa A, Sramkoski, R Michael, Babcock, George F

“…Normal human melanocytes and melanoma cells have been reported to produce several cytokines. Previously we demonstrated that neonatal human melanocyte…”
Get full text

Long-Term and Residual Melanotropin-Stimulated Tyrosinase Activity in S91 Melanoma Cells Is Density Dependent by Zalfa A. Abdel Malek, Kristie L. Kreutzfeld, Hadley, Mac E., Bregman, Marvin D., Hruby, Victor J., Frank L. Meyskens, Jr

“…Cell density is a factor that affects the capacity of Cloudman S91 melanoma cells to respond to melanotropins in monolayer culture. Continuous exposure of…”
Get full text

In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins by ABDEL-MALEK, Z. A, SWOPE, V. B, NITTAYAPORN AMORNSIRIPANITCH, NORDLUND, J. J

“…The effects of prostaglandins (PGs) on the Cloudman S91 melanoma CCL 53.1 cell line indicate that melanogenesis and proliferation are regulated by separate…”
Get full text

Melanoma prevention strategy based on using tetrapeptide α-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity by Abdel-Malek, Zalfa A, Kadekaro, Ana Luisa, Kavanagh, Renny J, Todorovic, Aleksandar, Koikov, Leonid N, McNulty, Joseph C, Jackson, Pilgrim J, Millhauser, Glenn L, Schwemberger, Sandy, Babcock, George, Haskell-Luevano, Carrie, Knittel, James J

“…Melanoma is the deadliest form of skin cancer, with no cure for advanced disease. We propose a strategy for melanoma prevention based on using analogs of…”
Get full text

Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis by Suzuki, I, Cone, R D, Im, S, Nordlund, J, Abdel-Malek, Z A

“…alpha-Melanocyte stimulating hormone (alpha-MSH) and ACTH increase the proliferation and melanogenesis of cultured human melanocytes. To further analyze how…”
Get full text

Hormonal effects of vitamin D3 on epidermal melanocytes by Abdel-Malek, Z A, Ross, R, Trinkle, L, Swope, V, Pike, J W, Nordlund, J J

“…The role of cholecalciferol, 25(OH) D3, and 1,25(OH)2 D3, as modulators of melanocyte function and proliferation has been examined. Topical application of 100…”
Get more information