Search Results - "Abdallah, Hassan H."
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Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes
Published in International journal of molecular sciences (18-05-2020)“…Cannabidiol (CBD) and cannabigerol (CBG) are terpenophenols. Although CBD's effectiveness against neurological diseases has already been demonstrated, nothing…”
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Towards the Pharmacological Validation and Phytochemical Profiling of the Decoction and Maceration of Bruguiera gymnorhiza (L.) Lam.-A Traditionally Used Medicinal Halophyte
Published in Molecules (Basel, Switzerland) (20-03-2022)“…Decoctions (leaves and roots) of (L.) Lam. are traditionally used against diabetes in many countries, including Mauritius. This study endeavoured to evaluate…”
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In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands
Published in Molecules (Basel, Switzerland) (01-12-2022)“…In this study, 10 essential oils (EOs), from nine plants ( , , , , , , , , and ) were assessed for their antimicrobial, antiaging and antiproliferative…”
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4
Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues
Published in PloS one (04-06-2019)“…Indolizines are heteroaromatic compounds, and their synthetic analogues have reportedly showed promising pharmacological properties. In this study, a series of…”
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In silico Exploration of Bioactive Phytochemicals Against Neurodegenerative Diseases Via Inhibition of Cholinesterases
Published in Current pharmaceutical design (01-01-2020)“…Neurodegenerative disorders are estimated to become the second leading cause of death worldwide by 2040. Despite the widespread use of diverse allopathic…”
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Bruguiera gymnorhiza (L.) Lam. at the Forefront of Pharma to Confront Zika Virus and Microbial Infections—An In Vitro and In Silico Perspective
Published in Molecules (Basel, Switzerland) (23-09-2021)“…The recent emergence of Zika virus (ZIKV) in Brazil and the increasing resistance developed by pathogenic bacteria to nearly all existing antibiotics should be…”
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Evaluation of Solubility, Dissolution Rate, and Oral Bioavailability of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin as Inclusion Complexes of the Tyrosine Kinase Inhibitor, Alectinib
Published in Pharmaceuticals (Basel, Switzerland) (05-06-2024)“…This study aims to improve the solubility and dissolution rate of alectinib (ALB), a tyrosine kinase inhibitor commonly used for treating non-small-cell…”
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Anti-Tubercular Properties of 4-Amino-5-(4-Fluoro-3- Phenoxyphenyl)-4H-1,2,4-Triazole-3-Thiol and Its Schiff Bases: Computational Input and Molecular Dynamics
Published in Antibiotics (Basel) (01-09-2020)“…In the present investigation, the parent compound 4-amino-5-(4-fluoro-3-phenoxyphenyl)-4H-1,2,4-triazole-3-thiol (1) and its Schiff bases 2, 3, and 4 were…”
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RP-UHPLC-MS Chemical Profiling, Biological and In Silico Docking Studies to Unravel the Therapeutic Potential of Heliotropium crispum Desf. as a Novel Source of Neuroprotective Bioactive Compounds
Published in Biomolecules (Basel, Switzerland) (04-01-2021)“…is one of the most important plant genera to have conventional folklore importance, and hence is a potential source of bioactive compounds. Thus, the present…”
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Dapsone is not a Pharmacodynamic Lead Compound for its Aryl Derivatives
Published in Current computer-aided drug design (01-01-2020)“…The relatedness between the linear equations of thermodynamics and QSAR was studied thanks to the recently elucidated crystal structure complexes between…”
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Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2- a ]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies
Published in Antibiotics (Basel) (07-05-2020)“…A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo[1,2- ]quinoline-3-carboxylates - and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo[1,2-…”
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Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using in Vitro Studies, in Silico Docking, and Multivariate Analysis
Published in Biomolecules (Basel, Switzerland) (07-05-2020)“…(L.) Lam. is claimed to effectively manage a number of ailments including diabetes and associated complications. Nonetheless, no attempt has been made to…”
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Are vanadium complexes druggable against the main protease M pro of SARS-CoV-2? - A computational approach
Published in Inorganica chimica acta (01-05-2021)“…techniques helped explore the binding capacities of the SARS-CoV-2 main protease (M ) for a series of metalloorganic compounds. Along with small size vanadium…”
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Phytochemical profiling, in vitro biological properties and in silico studies on Caragana ambigua stocks (Fabaceae): A comprehensive approach
Published in Industrial crops and products (01-05-2019)“…•The chemical composition and biological activities of extracts of C. ambigua were investigated.•Presence of bioactive compounds in ethyl acetate and n-hexane…”
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A comprehensive phytochemical, biological, toxicological and molecular docking evaluation of Suaeda fruticosa (L.) Forssk.: An edible halophyte medicinal plant
Published in Food and chemical toxicology (01-08-2021)“…Suaeda fruticosa is an edible medicinal halophyte known for its traditional uses. In this study, methanol and dichloromethane extracts of S. fruticosa were…”
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Insights into the mechanism and regioselectivity of the [3 + 2] cycloaddition reactions of cyclic nitrone to nitrile functions with a molecular electron density theory perspective
Published in Theoretical chemistry accounts (2021)“…A molecular electron density theory study is presented for [3 + 2] cycloaddition (32CA) reactions of 2,2-dimethyl-1-pyrroline-1-oxide with the nitrile…”
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Chemical reaction of soybean flavonoids with DNA: a computational study using the implicit solvent model
Published in International journal of molecular sciences (01-02-2012)“…Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically…”
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Theoretical Characterization of the Structure and Spectroscopy of HCNO2 Isomers and Applications
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (31-12-2020)“…We carried out a theoretical, fully ab initio, investigation of the stable forms of the [H,C,N,O,O] pentatomic molecular system, whose isomers are involved in…”
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Are vanadium complexes druggable against the main protease Mpro of SARS-CoV-2? – A computational approach
Published in Inorganica Chimica Acta (01-05-2021)“…[Display omitted] •In silico simulations were carried out to settle the intriguing question whether vanadium complexes of small organic compounds could act as…”
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20
Characterization of the simplest sulfenyl thiocyanate: isomers, spectroscopy and implications of astrophysical and biological relevance
Published in Physical chemistry chemical physics : PCCP (14-08-2020)“…Sulfenyl thiocyanate compounds, RSSCN, are involved in the human immune system biochemical processes. They are also the routes for the synthesis of complex…”
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