Search Results - "Abdalla, Ashraf N."

A Comprehensive Overview of Globally Approved JAK Inhibitors by Shawky, Ahmed M, Almalki, Faisal A, Abdalla, Ashraf N, Abdelazeem, Ahmed H, Gouda, Ahmed M

“…Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce…”
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Significance of Targeting VEGFR-2 and Cyclin D1 in Luminal-A Breast Cancer by Abdalla, Ashraf N, Qattan, Amal, Malki, Waleed H, Shahid, Imran, Hossain, Mohammad Akbar, Ahmed, Muhammad

“…The hormonal luminal-A is the most pre-dominant sub type of breast cancer (BC), and it is associated with a high level of cyclin D1 in Saudi patients…”
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Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells by Abdalla, Ashraf N, Shaheen, Usama, Abdallah, Qasem M A, Flamini, Guido, Bkhaitan, Majdi M, Abdelhady, Mohamed I S, Ascrizzi, Roberta, Bader, Ammar

“…Among the hundreds of reported species, (Labill.) DC. is one of the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a…”
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Genkwanin: An emerging natural compound with multifaceted pharmacological effects by El Menyiy, Naoual, Aboulaghras, Sara, Bakrim, Saad, Moubachir, Rania, Taha, Doaue, Khalid, Asaad, Abdalla, Ashraf N., Algarni, Alanood S., Hermansyah, Andi, Ming, Long Chiau, Rusu, Marius Emil, Bouyahya, Abdelhakim

“…Plant bioactive molecules could play key preventive and therapeutic roles in chronological aging and the pathogenesis of many chronic diseases, often…”
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Chemosensitization of HT29 and HT29-5FU Cell Lines by a Combination of a Multi-Tyrosine Kinase Inhibitor and 5FU Downregulates ABCC1 and Inhibits PIK3CA in Light of Their Importance in Saudi Colorectal Cancer by Abdalla, Ashraf N, Malki, Waleed H, Qattan, Amal, Shahid, Imran, Hossain, Mohammad Akbar, Ahmed, Muhammad

“…Colorectal cancer (CRC) remains one of the main causes of death worldwide and in Saudi Arabia. The toxicity and the development of resistance against 5…”
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Natural sources, biological effects, and pharmacological properties of cynaroside by Bouyahya, Abdelhakim, Taha, Douae, Benali, Taoufiq, Zengin, Gokhan, El Omari, Nasreddine, El Hachlafi, Naoufal, Khalid, Asaad, Abdalla, Ashraf N., Ardianto, Chrismawan, Tan, Ching Siang, Ming, Long Chiau, Sahib, Narjis

“…Cynaroside is a flavonoid, isolated from several species belonging to the Apiaceae, Poaceae, Lamiaceae, Solanaceae, Zingiberaceae, Compositae and other…”
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Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations by Samad, Abdus, Khurshid, Beenish, Mahmood, Arif, Rehman, Ashfaq Ur, Khalid, Asaad, Abdalla, Ashraf N., Algarni, Alanood S., Wadood, Abdul

“…The Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) serves as a molecular switch, cycling between guanosine triphosphate (GTP)-bound and inactive guanosine…”
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A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor by Al-Salem, Huda S, Arifuzzaman, Md, Alkahtani, Hamad M, Abdalla, Ashraf N, Issa, Iman S, Alqathama, Aljawharah, Albalawi, Fatemah S, Rahman, A F M Motiur

“…Isatin derivatives potentially act on various biological targets. In this article, a series of novel isatin-hydrazones were synthesized in excellent yields…”
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Bioactive substances of cyanobacteria and microalgae: Sources, metabolism, and anticancer mechanism insights by Bouyahya, Abdelhakim, Bakrim, Saad, Chamkhi, Imane, Taha, Douae, El Omari, Nasreddine, El Mneyiy, Naoual, El Hachlafi, Naoufal, El-Shazly, Mohamed, Khalid, Asaad, Abdalla, Ashraf N., Goh, Khang Wen, Ming, Long Chiau, Goh, Bey Hing, Aanniz, Tarik

“…Cyanobacteria and microalgae contain various phytochemicals, including bioactive components in the form of secondary metabolites, namely flavonoids, phenolic…”
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A Novel Approach to Develop New and Potent Inhibitors for the Simultaneous Inhibition of Protease and Helicase Activities of HCV NS3/4A Protease: A Computational Approach by Riaz, Muhammad, Rehman, Ashfaq Ur, Waqas, Muhammad, Khalid, Asaad, Abdalla, Ashraf N, Mahmood, Arif, Hu, Junjian, Wadood, Abdul

“…Infection of hepatitis C (HCV) is a major threat to human health throughout the world. The current therapy program suffers from restricted efficiency and low…”
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Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR by Almalki, Faisal A, Shawky, Ahmed M, Abdalla, Ashraf N, Gouda, Ahmed M

“…In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR…”
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Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress by Bouyahya, Abdelhakim, Bakrim, Saad, Aboulaghras, Sara, El Kadri, Kawtar, Aanniz, Tarik, Khalid, Asaad, Abdalla, Ashraf N., Abdallah, Ahmed A., Ardianto, Chrismawan, Ming, Long Chiau, El Omari, Nasreddine

“…Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of…”
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Structural, dynamic behaviour, in-vitro and computational investigations of Schiff’s bases of 1,3-diphenyl urea derivatives against SARS-CoV-2 spike protein by Ullah, Saeed, Ullah, Atta, Waqas, Muhammad, Halim, Sobia Ahsan, Pasha, Anam Rubbab, Shafiq, Zahid, Mali, Suraj N., Jawarkar, Rahul D., Khan, Ajmal, Khalid, Asaad, Abdalla, Ashraf N., Kashtoh, Hamdy, Al-Harrasi, Ahmed

“…The COVID-19 has had a significant influence on people's lives across the world. The viral genome has undergone numerous unanticipated changes that have given…”
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Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and induction of cellular cell death related to cellular stresses by El Omari, Nasreddine, Bakrim, Saad, Khalid, Asaad, Abdalla, Ashraf N., Almalki, Waleed Hassan, Lee, Learn-Han, Ardianto, Chrismawan, Ming, Long Chiau, Bouyahya, Abdelhakim

“…Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a hydroxamic acid that has been approved by the Food and Drug Administration…”
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Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities by Shawky, Ahmed M., Ibrahim, Nashwa A., Abourehab, Mohammed A. S., Abdalla, Ashraf N., Gouda, Ahmed M.

“…In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were…”
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Unveiling the Antioxidant, Clinical Enzyme Inhibitory Properties and Cytotoxic Potential of Tambourissa peltata Baker-An Understudied Endemic Plant by Suroowan, Shanoo, Llorent-Martínez, Eulogio J, Zengin, Gokhan, Buskaran, Kalaivani, Fakurazi, Sharida, Abdalla, Ashraf N, Khalid, Asaad, Le Van, Bao, Mahomoodally, Mohamad Fawzi

“…This study documents for the first time the phytochemical composition and biological activities of Baker, an endemic plant from Mauritius. Phytochemical…”
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Recent advances and molecular mechanisms of TGF-β signaling in colorectal cancer, with focus on bioactive compounds targeting by Bakrim, Saad, El Hachlafi, Naoufal, Khalid, Asaad, Abdalla, Ashraf N., El Omari, Nasreddine, Aboulaghras, Sara, Sakran, Ashraf M., Goh, Khang Wen, Ming, Long Chiau, Razi, Pakhrur, Bouyahya, Abdelhakim

“…Colorectal cancer (CRC) is one of the most significant forms of human cancer. It is characterized by its heterogeneity because several molecular factors are…”
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In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands by Jugreet, Bibi Sharmeen, Lall, Namrita, Anina Lambrechts, Isa, Reid, Anna-Mari, Maphutha, Jacqueline, Nel, Marizé, Hassan, Abdallah H, Khalid, Asaad, Abdalla, Ashraf N, Van, Bao Le, Mahomoodally, Mohamad Fawzi

“…In this study, 10 essential oils (EOs), from nine plants ( , , , , , , , , and ) were assessed for their antimicrobial, antiaging and antiproliferative…”
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Anticancer clinical efficiency and stochastic mechanisms of belinostat by El Omari, Nasreddine, Bakrim, Saad, Khalid, Asaad, Albratty, Mohammed, Abdalla, Ashraf N., Lee, Learn-Han, Goh, Khang Wen, Ming, Long Chiau, Bouyahya, Abdelhakim

“…Cancer progression is strongly affected by epigenetic events in addition to genetic modifications. One of the key elements in the epigenetic control of gene…”
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Anticancer properties and mechanism insights of α-hederin by Belmehdi, Omar, Taha, Douae, Abrini, Jamal, Ming, Long Chiau, Khalid, Asaad, Abdalla, Ashraf N., Algarni, Alanood S., Hermansyah, Andi, Bouyahya, Abdelhakim

“…α-Hederin is a natural bioactive molecule very abundant in aromatic and medicinal plants (AMP). It was identified, characterized, and isolated using different…”
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