Search Results - "Abd Alla, Joshua"

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart by Abd Alla, Joshua, Quitterer, Ursula

“…The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G protein-coupled receptor kinase 2, GRK2. By inhibition of the…”
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Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor by Perhal, Alexander, Wolf, Stefan, Jamous, Yahya F, Langer, Andreas, Abd Alla, Joshua, Quitterer, Ursula

“…Atherosclerosis and ensuing cardiovascular disease are major causes of death with insufficient treatment options. In search for pathomechanisms of…”
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Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice by Abd Alla, Joshua, Graemer, Muriel, Fu, Xuebin, Quitterer, Ursula

“…Impairment of myocardial fatty acid substrate metabolism is characteristic of late-stage heart failure and has limited treatment options. Here, we investigated…”
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Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation by Abd Alla, Joshua, Jamous, Yahya F., Quitterer, Ursula

“…Heart failure is a major cause of death worldwide with insufficient treatment options. In the search for pathomechanisms, we found up-regulation of an enzyme,…”
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Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure by Wolf, Stefan, Abd Alla, Joshua, Quitterer, Ursula

“…Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms…”
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Calreticulin enhances B2 bradykinin receptor maturation and heterodimerization by Abd Alla, Joshua, Reeck, Kristin, Langer, Andreas, Streichert, Thomas, Quitterer, Ursula

“…In different native tissues and cells the receptor for the vasodepressor bradykinin, B 2, forms dimers with the receptor for the vasopressor angiotensin II, AT…”
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Angiotensin-converting Enzyme Inhibition Down-regulates the Pro-atherogenic Chemokine Receptor 9 (CCR9)-Chemokine Ligand 25 (CCL25) Axis by Abd Alla, Joshua, Langer, Andreas, Elzahwy, Sherif S., Arman-Kalcek, Gökhan, Streichert, Thomas, Quitterer, Ursula

“…Many experimental and clinical studies suggest a relationship between enhanced angiotensin II release by the angiotensin-converting enzyme (ACE) and the…”
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Microarray gene expression profiling reveals antioxidant-like effects of angiotensin II inhibition in atherosclerosis by Abd Alla, Joshua, El Faramawy, Yasser, Quitterer, Ursula

“…Reactive oxygen species (ROS) is a significant feature of atherosclerosis but the impact of ROS on atherogenesis is not clear since antioxidants such as…”
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Identification of membrane palmitoylated protein 1 (MPP1) as a heart-failure-promoting protein triggered by cardiovascular risk factors and aging by Alla, Joshua Abd, Nerger, Eric, Langer, Andreas, Quitterer, Ursula

“…[Display omitted] Membrane-Associated Guanylate Kinase (MAGUK) proteins are scaffold proteins with well-established functions in the neuronal system. A role of…”
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Elevated BBLN levels as a cause of heart defects in tetralogy of Fallot

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Inhibition of G-protein-coupled Receptor Kinase 2 (GRK2) Triggers the Growth-promoting Mitogen-activated Protein Kinase (MAPK) Pathway by Fu, Xuebin, Koller, Samuel, Abd Alla, Joshua, Quitterer, Ursula

“…Inhibition of G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment option for heart failure. Because GRK2 is also indispensable for growth and…”
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Establishment of an in vivo model facilitates B2 receptor protein maturation and heterodimerization by Abd Alla, Joshua, Pohl, Armin, Reeck, Kristin, Streichert, Thomas, Quitterer, Ursula

“…In individuals with diverse cardiovascular risk factors, signalling stimulated by the AT(1) receptor for the vasopressor angiotensin II is sensitized by…”
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