Search Results - "Abd, Yasmine S El"
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Peripheral immune signatures associated with the risk of hepatocarcinogenesis in cirrhotic Egyptian HCV patients before and after treatment with direct-acting antivirals
Published in Virology journal (15-11-2024)“…Although direct-acting antivirals (DAAs) have revolutionized the management of chronic HCV, the debatable association with hepatocellular carcinoma (HCC)…”
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Glycylglycine promotes the solubility and antigenic utility of recombinant HCV structural proteins in a point-of-care immunoassay for detection of active viremia
Published in Microbial cell factories (18-01-2024)“…Although E. coli is generally a well-opted platform for the overproduction of recombinant antigens as heterologous proteins, the optimization of expression…”
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Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity
Published in Virology journal (15-05-2023)“…Coronavirus Disease 2019 (COVID-19) is a worldwide pandemic challenge spreading enormously within a few months. COVID-19 is characterized by the…”
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Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats
Published in Virology journal (27-05-2009)“…The reason(s) why human antibodies raised against hepatitis C virus (HCV) E2 epitopes do not offer protection against multiple viral infections may be related…”
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Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases
Published in Journal of advanced research (01-07-2017)“…[Display omitted] The major histocompatibility complex class I-related gene A (MICA) is an antigen induced by stress and performs an integral role in immune…”
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Neutralizing activities of caprine antibodies towards conserved regions of the HCV envelope glycoprotein E2
Published in Virology journal (05-08-2011)“…Anti HCV vaccine is not currently available and the present antiviral therapies fail to cure approximately half of the treated HCV patients. This study was…”
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HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro
Published in World journal of gastroenterology : WJG (14-08-2006)“…AIM: TO establish a cell culture system with longterm replication of hepatitis C virus (HCV) genome and expression of viral antigens in vitro. METHODS: HepG2…”
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Part I: Design, synthesis and biological evaluation of novel pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors with studying their activities alone and in combination with genotoxic drugs
Published in European journal of medicinal chemistry (07-07-2017)“…Activated checkpoint kinase 2 (Chk2) is a tumor suppressor as one of the main enzymes that affect the cell cycle. 2-Biarylbenzimidazoles are potent selective…”
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Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates
Published in European journal of medicinal chemistry (25-02-2018)“…Recently a dramatic development of the cancer drug discovery has been shown in the field of targeted cancer therapy. Checkpoint kinase 2 (Chk2) inhibitors…”
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Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors
Published in European journal of medicinal chemistry (20-01-2018)“…The development of checkpoint kinase 2 (Chk2) inhibitors for the treatment of cancer has been an ongoing and attractive objective in drug discovery. In this…”
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Association of Myxovirus Resistance Gene Promoter Polymorphism with Response to Combined Interferon Treatment and Progression of Liver Disease in Chronic HCV Egyptian Patients
Published in Journal of interferon & cytokine research (01-08-2015)“…To evaluate the frequency of single-nucleotide polymorphism at the -88 myxovirus resistance (MxA) gene promoter region in relation to the status of hepatitis C…”
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Importance of studying the levels of hepcidin and vitamin D in Egyptian children with chronic hepatitis C
Published in Journal of translational internal medicine (29-03-2019)Get full text
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Circulating viral core and E1 antigen levels as supplemental markers for HCV chronic hepatitis
Published in Virology journal (01-09-2006)“…The performance of polyclonal monospecific rabbit anti-sera raised against synthetic peptides derived from conserved HCV sequences of genotype 4 was evaluated…”
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Diagnosis of Hepatitis C Virus Infection Using a Novel Mouse Monoclonal Antibody to Detect Serum HCV E1/E2 Antigens
Published in Clinical laboratory (Heidelberg) (01-01-2017)“…Hepatitis C virus (HCV) is a major cause of liver disease worldwide and in Egypt. The aim of this study was to detect HCV E1/E2 antigens using a novel mouse…”
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Methylene Tetrahydrofolate Reductase Gene Polymorphism is Associated with Severity of Liver Steatosis in Chronically Infected Patients with HCV Genotype 4
Published in Clinical laboratory (Heidelberg) (01-01-2017)“…Methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism was reported as a genetic variant in liver steatosis and fibrosis. This is a study of the…”
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Level of Human Antibodies Targeting HCV E1/E2 Peptides and Spontaneous Clearance of HCV in Blood Donors
Published in Clinical laboratory (Heidelberg) (01-01-2016)“…Hepatitis C virus (HCV) is a major health problem worldwide particularly in Egypt. The humoral immune response has an important function in the control of HCV…”
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Low Molecular Mass Polypeptide 7 Single Nucleotide Polymorphism is Associated with the Progression of Liver Fibrosis in Patients Infected with Hepatitis C Virus Genotype 4
Published in Clinical laboratory (Heidelberg) (2016)“…The hepatitis C virus (HCV) is a leading cause of liver disease and the consequent complications of cirrhosis. However, there is no precise biomarker to…”
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Alteration of the Total Nuclear DNA Ploidy in Different Histopathological Liver Tissues Negative and Positive for HCV RNA
Published in Clinical laboratory (Heidelberg) (2015)“…Hepatitis C virus (HCV) infection is associated with the development of hepatocellular carcinoma (HCC). The molecular mechanisms of HCV-associated…”
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MOUSE MONOCLONAL ANTIBODY TOWARDS E1 SPECIFIC EPITOPE BLOCKS VIRAL ENTRY AND INTRACELLULAR VIRAL REPLICATION IN VITRO
Published in Journal of immunoassay & immunochemistry (02-01-2014)“…We characterized viral neutralization by a murine monoclonal antibody (mAb315) developed against conserved E1 specific epitope aa 315-323 at pre- and…”
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IN VITRO NEUTRALIZATION OF HCV BY GOAT ANTIBODIES AGAINST PEPTIDES ENCOMPASSING REGIONS DOWNSTREAM OF HVR-1 OF E2 GLYCOPROTEIN
Published in Journal of immunoassay & immunochemistry (2014)“…This article has been retracted…”
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