Search Results - "Abboud, E."

Subcellular localization of Nox4 and regulation in diabetes by Block, Karen, Gorin, Yves, Abboud, Hanna E

“…Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H oxidases have been identified not…”
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Deviatoric stress waves due to rheology in incompressible thermoviscoelastic solid medium with small strain, small deformation physics by Surana, K. S., Abboud, E.

“…This paper demonstrates existence of deviatoric stress waves in thermoviscoelastic (TVE) solid continua due to rheology in addition to the presence of usual…”
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AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes by Eid, Assaad A., Ford, Bridget M., Block, Karen, Kasinath, Balakuntalam S., Gorin, Yves, Ghosh-Choudhury, Goutam, Barnes, Jeffrey L., Abboud, Hanna E.

“…Diabetes and high glucose (HG) increase the generation of NADPH oxidase-derived reactive oxygen species and induce apoptosis of glomerular epithelial cells…”
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Activation of AMP-Activated Protein Kinase Prevents TGF-β1–Induced Epithelial-Mesenchymal Transition and Myofibroblast Activation by Thakur, Sachin, Viswanadhapalli, Suryavathi, Kopp, Jeffrey B, Shi, Qian, Barnes, Jeffrey L, Block, Karen, Gorin, Yves, Abboud, Hanna E

“…Transforming growth factor (TGF)-β contributes to tubulointerstitial fibrosis. We investigated the mechanism by which TGF-β exerts its profibrotic effects and…”
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Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury by EID, Assaad A, FORD, Bridget M, BHANDARY, Basant, DE CASSIA CAVAGLIERI, Rita, BLOCK, Karen, BARNES, Jeffrey L, GORIN, Yves, GOUTAM GHOSH CHOUDHURY, ABBOUD, Hanna E

“…Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Pharmacological doses of the mammalian…”
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Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation by Mandal, Chandi C, Ganapathy, Suthakar, Gorin, Yves, Mahadev, Kalyankar, Block, Karen, Abboud, Hanna E, Harris, Stephen E, Ghosh-Choudhury, Goutam, Ghosh-Choudhury, Nandini

“…BMP-2 (bone morphogenetic protein-2) promotes differentiation of osteoblast precursor cells to mature osteoblasts that form healthy bone. In the present study,…”
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Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells by Lee, Hak Joo, Mariappan, Meenalakshmi M., Feliers, Denis, Cavaglieri, Rita C., Sataranatarajan, Kavithalakshmi, Abboud, Hanna E., Choudhury, Goutam Ghosh, Kasinath, Balakuntalam S.

“…Hydrogen sulfide, a signaling gas, affects several cell functions. We hypothesized that hydrogen sulfide modulates high glucose (30 mm) stimulation of matrix…”
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Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes by Maalouf, Rita M, Eid, Assaad A, Gorin, Yves C, Block, Karen, Escobar, Gladys Patricia, Bailey, Steven, Abboud, Hanna E

“…Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS)…”
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Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers by Debnath, Subrata, Velagapudi, Chakradhar, Redus, Laney, Thameem, Farook, Kasinath, Balakuntalam, Hura, Claudia E, Lorenzo, Carlos, Abboud, Hanna E, O’Connor, Jason C

“…Objective: Type 2 diabetes (T2D) is the primary case of chronic kidney disease (CKD). Inflammation is associated with metabolic dysregulation in patients with…”
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Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes by Graham, Sarabeth, Gorin, Yves, Abboud, Hanna E, Ding, Min, Lee, Duck Yoon, Shi, Honglian, Ding, Yanfeng, Ma, Rong

“…The present study was performed to investigate the underlying mechanism, particularly the roles of reactive oxygen species (ROS) and protein kinase C (PKC), in…”
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microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion by Dey, Nirmalya, Das, Falguni, Ghosh-Choudhury, Nandini, Mandal, Chandi Charan, Parekh, Dipen J, Block, Karen, Kasinath, Balakuntalam S, Abboud, Hanna E, Choudhury, Goutam Ghosh

“…Metastatic renal cancer manifests multiple signatures of gene expression. Deviation in expression of mature miRNAs has been linked to human cancers. Importance…”
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Tuberin regulates reactive oxygen species in renal proximal cells, kidney from rodents, and kidney from patients with tuberous sclerosis complex by Habib, Samy L., Abboud, Hanna E.

“…Reactive oxygen species (ROS) are an important endogenous source of DNA damage and oxidative stress in all cell types. Deficiency in tuberin resulted in…”
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TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression by Das, Falguni, Bera, Amit, Ghosh-Choudhury, Nandini, Abboud, Hanna E, Kasinath, Balakuntalam S, Choudhury, Goutam Ghosh

“…Enhanced TGFβ activity contributes to the accumulation of matrix proteins including collagen I (α2) by proximal tubular epithelial cells in progressive kidney…”
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High d (+)glucose concentration inhibits RANKL-induced osteoclastogenesis by Wittrant, Y, Gorin, Y, Woodruff, K, Horn, D, Abboud, H.E, Mohan, S, Abboud-Werner, S.L

“…Abstract Diabetes is a chronic disease associated with hyperglycemia and altered bone metabolism that may lead to complications including osteopenia, increased…”
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Vitreous levels of placental growth factor correlate with activity of proliferative diabetic retinopathy and are not influenced by bevacizumab treatment by Al Kahtani, E, Xu, Z, Al Rashaed, S, Wu, L, Mahale, A, Tian, J, Abboud, E B, Ghazi, N G, Kozak, I, Gupta, V, Arevalo, J F, Duh, E J

“…Purpose Placental growth factor (PlGF) is a member of the VEGF family that plays an important role in experimental models of diabetic retinopathy and retinal…”
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The Tuberin/mTOR Pathway Promotes Apoptosis of Tubular Epithelial Cells in Diabetes by VELAGAPUDI, Chakradhar, BHANDARI, Basant S, ABBOUD-WERNER, Sherry, SIMONE, Simona, ABBOUD, Hanna E, HABIB, Samy L

“…Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose (HG) induces apoptosis is not fully understood…”
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ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease by Beck Gooz, Monika, Maldonado, Eduardo N, Dang, Yujing, Amria, May Y, Higashiyama, Shigeki, Abboud, Hanna E, Lemasters, John J, Bell, P Darwin

“…Polycystic kidney disease (PKD) is a common genetic disorder leading to cyst formation in the kidneys and other organs that ultimately results in kidney…”
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ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice by Ford, Bridget M, Eid, Assaad A, Göőz, Monika, Barnes, Jeffrey L, Gorin, Yves C, Abboud, Hanna E

“…Matrix protein accumulation is a prominent feature of diabetic nephropathy that contributes to renal fibrosis and decline in renal function. The pathogenic…”
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Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells by Gorin, Yves, Ricono, Jill M, Kim, Nam-Ho, Bhandari, Basant, Choudhury, Goutam Ghosh, Abboud, Hanna E

“…ANG II induces protein synthesis through the serine-threonine kinase Akt/protein kinase B (PKB) in mesangial cells (MCs). The mechanism(s) of activation of…”
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Mesangial cell biology by Abboud, Hanna E.

“…Mesangial cells originate from the metanephric mesenchyme and maintain structural integrity of the glomerular microvascular bed and mesangial matrix…”
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