Search Results - "Abbott, Sarah K."

Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease by Murphy, Karen E., Gysbers, Amanda M., Abbott, Sarah K., Spiro, Adena S., Furuta, Akiko, Cooper, Antony, Garner, Brett, Kabuta, Tomohiro, Halliday, Glenda M.

“…ABSTRACT Lysosomes are the primary catabolic compartment for the degradation of intracellular proteins through autophagy. The presence of abnormal…”
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Fatty acid composition of membrane bilayers: Importance of diet polyunsaturated fat balance by Abbott, Sarah K., Else, Paul L., Atkins, Taleitha A., Hulbert, A.J.

“…In one of the most extensive analyses to date we show that the balance of diet n−3 and n−6 polyunsaturated fatty acids (PUFA) is the most important determinant…”
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Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease by Abbott, Sarah K., Li, Hongyun, Muñoz, Sonia Sanz, Knoch, Bianca, Batterham, Marijka, Murphy, Karen E., Halliday, Glenda M., Garner, Brett

“…ABSTRACT Genetic studies have provided increasing evidence that ceramide homeostasis plays a role in neurodegenerative diseases including Parkinson's disease…”
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An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids by Abbott, Sarah K., Jenner, Andrew M., Mitchell, Todd W., Brown, Simon H. J., Halliday, Glenda M., Garner, Brett

“…We have developed a protocol suitable for high-throughput lipidomic analysis of human brain samples. The traditional Folch extraction (using chloroform and…”
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The burden of size and growth for the juveniles of large mammalian herbivores: Structural and functional constraints in the feeding biology of juveniles relative to adults in red kangaroos, Osphranter rufus by Dawson, Terence J., Norton, Melinda A., Rodoreda, Suzette, Abbott, Sarah K., McLeod, Steven R.

“…Juvenile mammals in their postweaning developmental stages face many challenges in transitioning to adulthood. Among large grazing species such as ruminant…”
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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease by MURPHY, Karen E, GYSBERS, Amanda M, ABBOTT, Sarah K, TAYEBI, Nahid, KIM, Woojin S, SIDRANSKY, Ellen, COOPER, Antony, GARNER, Brett, HALLIDAY, Glenda M

“…Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are the most frequent known genetic risk factor for Parkinson's disease…”
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Polyunsaturated fats, membrane lipids and animal longevity by Hulbert, A. J., Kelly, Megan A., Abbott, Sarah K.

“…Fatty acids are essential for life because they are essential components of cellular membranes. Lower animals can synthesize all four classes of fatty acids…”
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Advances and unresolved challenges in the structural characterization of isomeric lipids by Hancock, Sarah E., Poad, Berwyck L.J., Batarseh, Amani, Abbott, Sarah K., Mitchell, Todd W.

“…As the field of lipidomics grows and its application becomes wide and varied it is important that we don't forget its foundation, i.e. the identification and…”
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Membrane fatty acid composition of rat skeletal muscle is most responsive to the balance of dietary n-3 and n-6 PUFA by Abbott, Sarah K., Else, Paul L., Hulbert, A. J.

“…The present study quantifies the relationships between diet fatty acid profile and fatty acid composition of rat skeletal muscle phospholipids. Young adult…”
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Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease by Abbott, Sarah K, Jenner, Andrew M, Spiro, Adena S, Batterham, Marijka, Halliday, Glenda M, Garner, Brett

“…Oxidative stress contributes to Parkinson's disease (PD) etiology. Although previous studies have focused on sources of free radical formation in brain regions…”
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Phospholipid composition of the rat lens is independent of diet by Nealon, Jessica R., Blanksby, Stephen J., Abbott, Sarah K., Hulbert, A.J., Mitchell, Todd W., Truscott, Roger J.W.

“…Dietary fatty acids are known to influence the phospholipid composition of many tissues in the body, with lipid turnover occurring rapidly. The aim of this…”
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Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation by Batarseh, Amani M., Abbott, Sarah K., Duchoslav, Eva, Alqarni, Ayedh, Blanksby, Stephen J., Mitchell, Todd W.

“…[Display omitted] •A unique mass spectrometry workflow for enhanced lipid isomer identification.•New software for automated annotation of ozone-induced…”
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Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease: Early loss of LAMP2A protein in PD by Murphy, Karen E., Gysbers, Amanda M., Abbott, Sarah K., Spiro, Adena S., Furuta, Akiko, Cooper, Antony, Garner, Brett, Kabuta, Tomohiro, Halliday, Glenda M.

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