Search Results - "Abbott, Keene L"

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer by Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Faubert, Brandon, Chan, Sze Ham, Freinkman, Elizaveta, Zacharias, Lauren G., Mathews, Thomas P., Clish, Clary B., DeBerardinis, Ralph J., Lewis, Caroline A., Vander Heiden, Matthew G.

“…Increased glucose uptake and metabolism is a prominent phenotype of most cancers, but efforts to clinically target this metabolic alteration have been…”
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The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients by Abbott, Keene L, Vander Heiden, Matthew G

“…The extent to which tumors acquire nutrients from dietary sources as opposed to from the breakdown of host tissues is not known. In this issue of BMC Biology,…”
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Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening by Ramos, Azucena, Koch, Catherine E., Liu-Lupo, Yunpeng, Hellinger, Riley D., Kyung, Taeyoon, Abbott, Keene L., Fröse, Julia, Goulet, Daniel, Gordon, Khloe S., Eidell, Keith P., Leclerc, Paul, Whittaker, Charles A., Larson, Rebecca C., Muscato, Audrey J., Yates, Kathleen B., Dubrot, Juan, Doench, John G., Regev, Aviv, Vander Heiden, Matthew G., Maus, Marcela V., Manguso, Robert T., Birnbaum, Michael E., Hemann, Michael T.

“…CAR-T therapy is a promising, novel treatment modality for B-cell malignancies and yet many patients relapse through a variety of means, including loss of…”
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Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability by Abbott, Keene L, Ali, Ahmed, Reinfeld, Bradley I, Deik, Amy, Subudhi, Sonu, Landis, Madelyn D, Hongo, Rachel A, Young, Kirsten L, Kunchok, Tenzin, Nabel, Christopher S, Crowder, Kayla D, Kent, Johnathan R, Madariaga, Maria Lucia L, Jain, Rakesh K, Beckermann, Kathryn E, Lewis, Caroline A, Clish, Clary B, Muir, Alexander, Rathmell, W Kimryn, Rathmell, Jeffrey, Vander Heiden, Matthew G

“…The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it…”
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Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma by Qin, Elizabeth Y., Cooper, Dominique D., Abbott, Keene L., Lennon, James, Nagaraja, Surya, Mackay, Alan, Jones, Chris, Vogel, Hannes, Jackson, Peter K., Monje, Michelle

“…The lateral ventricle subventricular zone (SVZ) is a frequent and consequential site of pediatric and adult glioma spread, but the cellular and…”
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Manipulating mitochondrial electron flow enhances tumor immunogenicity by Mangalhara, Kailash Chandra, Varanasi, Siva Karthik, Johnson, Melissa A, Burns, Mannix J, Rojas, Gladys R, Esparza Moltó, Pau B, Sainz, Alva G, Tadepalle, Nimesha, Abbott, Keene L, Mendiratta, Gaurav, Chen, Dan, Farsakoglu, Yagmur, Kunchok, Tenzin, Hoffmann, Filipe Araujo, Parisi, Bianca, Rincon, Mercedes, Vander Heiden, Matthew G, Bosenberg, Marcus, Hargreaves, Diana C, Kaech, Susan M, Shadel, Gerald S

“…Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the…”
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Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities by Kelly, Marcus R, Kostyrko, Kaja, Han, Kyuho, Mooney, Nancie A, Jeng, Edwin E, Spees, Kaitlyn, Dinh, Phuong T, Abbott, Keene L, Gwinn, Dana M, Sweet-Cordero, E Alejandro, Bassik, Michael C, Jackson, Peter K

“…Activating mutations in RAS GTPases drive many cancers, but limited understanding of less-studied RAS interactors, and of the specific roles of different RAS…”
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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress by Do, Brian T, Hsu, Peggy P, Vermeulen, Sidney Y, Wang, Zhishan, Hirz, Taghreed, Abbott, Keene L, Aziz, Najihah, Replogle, Joseph M, Bjelosevic, Stefan, Paolino, Jonathan, Nelson, Samantha A, Block, Samuel, Darnell, Alicia M, Ferreira, Raphael, Zhang, Hanyu, Milosevic, Jelena, Schmidt, Daniel R, Chidley, Christopher, Harris, Isaac S, Weissman, Jonathan S, Pikman, Yana, Stegmaier, Kimberly, Cheloufi, Sihem, Su, Xiaofeng A, Sykes, David B, Vander Heiden, Matthew G

“…Control of cellular identity requires coordination of developmental programs with environmental factors such as nutrient availability, suggesting that…”
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Screening in serum-derived medium reveals differential response to compounds targeting metabolism by Abbott, Keene L, Ali, Ahmed, Casalena, Dominick, Do, Brian T, Ferreira, Raphael, Cheah, Jaime H, Soule, Christian K, Deik, Amy, Kunchok, Tenzin, Schmidt, Daniel R, Renner, Steffen, Honeder, Sophie E, Wu, Michelle, Chan, Sze Ham, Tseyang, Tenzin, Stoltzfus, Andrew T, Michel, Sarah L J, Greaves, Daniel, Hsu, Peggy P, Ng, Christopher W, Zhang, Chelsea J, Farsidjani, Ali, Kent, Johnathan R, Madariaga, Maria Lucia L, Gramatikov, Iva Monique T, Matheson, Nicholas J, Lewis, Caroline A, Clish, Clary B, Rees, Matthew G, Roth, Jennifer A, Griner, Lesley Mathews, Muir, Alexander, Auld, Douglas S, Vander Heiden, Matthew G

“…A challenge for screening new anticancer drugs is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of…”
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Differential substrate use in EGF‐ and oncogenic KRAS‐stimulated human mammary epithelial cells by Keibler, Mark A., Dong, Wentao, Korthauer, Keegan D., Hosios, Aaron M., Moon, Sun Jin, Sullivan, Lucas B., Liu, Nian, Abbott, Keene L., Arevalo, Orlando D., Ho, Kailing, Lee, Jennifer, Phanse, Aasavari S., Kelleher, Joanne K., Iliopoulos, Othon, Coloff, Jonathan L., Vander Heiden, Matthew G., Stephanopoulos, Gregory

“…Many metabolic phenotypes in cancer cells are also characteristic of proliferating nontransformed mammalian cells, and attempts to distinguish between…”
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Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited by Li, Zhaoqi, Ji, Brian W., Dixit, Purushottam D., Tchourine, Konstantine, Lien, Evan C., Hosios, Aaron M., Abbott, Keene L., Rutter, Justine C., Westermark, Anna M., Gorodetsky, Elizabeth F., Sullivan, Lucas B., Vander Heiden, Matthew G., Vitkup, Dennis

“…Production of oxidized biomass, which requires regeneration of the cofactor NAD + , can be a proliferation bottleneck that is influenced by environmental…”
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Cancer tissue of origin constrains the growth and metabolism of metastases by Sivanand, Sharanya, Gultekin, Yetis, Winter, Peter S., Vermeulen, Sidney Y., Tchourine, Konstantine M., Abbott, Keene L., Danai, Laura V., Gourgue, Florian, Do, Brian T., Crowder, Kayla, Kunchok, Tenzin, Lau, Allison N., Darnell, Alicia M., Jefferson, Alexandria, Morita, Satoru, Duda, Dan G., Aguirre, Andrew J., Wolpin, Brian M., Henning, Nicole, Spanoudaki, Virginia, Maiorino, Laura, Irvine, Darrell J., Yilmaz, Omer H., Lewis, Caroline A., Vitkup, Dennis, Shalek, Alex K., Vander Heiden, Matthew G.

“…Metastases arise from subsets of cancer cells that disseminate from the primary tumour 1 , 2 . The ability of cancer cells to thrive in a new tissue site is…”
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Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis by Ferraro, Gino B, Ali, Ahmed, Luengo, Alba, Kodack, David P, Deik, Amy, Abbott, Keene L, Bezwada, Divya, Blanc, Landry, Prideaux, Brendan, Jin, Xin, Posada, Jessica M, Chen, Jiang, Chin, Christopher R, Amoozgar, Zohreh, Ferreira, Raphael, Chen, Ivy X, Naxerova, Kamila, Ng, Christopher, Westermark, Anna M, Duquette, Mark, Roberge, Sylvie, Lindeman, Neal I, Lyssiotis, Costas A, Nielsen, Jens, Housman, David E, Duda, Dan G, Brachtel, Elena, Golub, Todd R, Cantley, Lewis C, Asara, John M, Davidson, Shawn M, Fukumura, Dai, Dartois, Véronique A, Clish, Clary B, Jain, Rakesh K, Vander Heiden, Matthew G

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FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS by Ferraro, Gino B, Ali, Ahmed, Luengo, Alba, Kodack, David P, Deik, Amy, Abbott, Keene L, Bezwada, Divya, Blanc, Landry, Prideaux, Brendan, Jin, Xin, Posada, Jessica M, Chen, Jiang, Chin, Christopher R, Amoozgar, Zohreh, Ferreira, Raphael, Chen, Ivy X, Naxerova, Kamila, Ng, Christopher, Westermark, Anna M, Duquette, Mark, Roberge, Sylvie, Lindeman, Neal I, Lyssiotis, Costas A, Nielsen, Jens, Housman, David E, Duda, Dan G, Brachtel, Elena, Golub, Todd R, Cantley, Lewis C, Asara, John M, Davidson, Shawn M, Fukumura, Dai, Dartois, Véronique A, Clish, Clary B, Jain, Rakesh K, Vander Heiden, Matthew G

“…Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and…”
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Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability by Abbott, Keene L, Ali, Ahmed, Reinfeld, Bradley I, Deik, Amy, Subudhi, Sonu, Landis, Madelyn D, Hongo, Rachel A, Young, Kirsten L, Kunchok, Tenzin, Nabel, Christopher S, Crowder, Kayla D, Kent, Johnathan R, Madariaga, Maria Lucia L, Jain, Rakesh K, Beckermann, Kathryn E, Lewis, Caroline A, Clish, Clary B, Muir, Alexander, Rathmell, W Kimryn, Rathmell, Jeffrey, Vander Heiden, Matthew G

“…The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it…”
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Abstract 90: Fatty acid synthesis is required for breast cancer brain metastasis by Ferraro, Gino B., Ali, Ahmed, Luengo, Alba, Kodack, David P., Deik, Amy, Abbott, Keene L., Bezwada, Divya, Blanc, Landry, Prideaux, Brendan, Jin, Xin, Possada, Jessica M., Chen, Jiang, Chin, Christopher R., Amoozgar, Zohreh, Ferreira, Raphael, Chen, Ivy, Naxerova, Kamila, Ng, Christopher, Westermark, Anna M., Duquette, Mark, Roberge, Sylvie, Lyssiotis, Costas A., Duda, Dan G., Golub, Todd R., Davidson, Shawn M., Fukumura, Dai, Dartois, Véronique A., Clish, Clary B., Heiden, Matthew G. Vander, Jain, Rakesh K.

“…Abstract Brain metastases are refractory to therapies that otherwise control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+)…”
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