Search Results - "Abbott, Karen L"

The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer by Allam, Heba, Johnson, Blake P., Zhang, Mao, Lu, Zhongpeng, Cannon, Martin J., Abbott, Karen L.

“…Glycosylation changes associated with cellular transformation can facilitate the growth and progression of tumors. Previously we discovered that the gene Mgat3…”
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Novel Methods and Pathways in Cancer Glycobiology Research by Dimitroff, Charles J, Abbott, Karen

“…Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for…”
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Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche by Rikitake, Marika, Matsuda, Ayako, Murata, Daisuke, Dejima, Katsufumi, Nomura, Kazuko H, Abbott, Karen L, Mitani, Shohei, Nomura, Kazuya

“…Abstract Stem cells divide and undergo self-renewal depending on the signals received from the stem cell niche. This phenomenon is indispensable to maintain…”
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Lectin-based glycoproteomic techniques for the enrichment and identification of potential biomarkers by Abbott, Karen L, Pierce, J Michael

“…Glycan structures on glycoproteins are controlled by several factors such as regulated expression of glycosyltransferases and glycosylhydrolases, as well as…”
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Proteomic Identification of Glycosylphosphatidylinositol Anchor-dependent Membrane Proteins Elevated in Breast Carcinoma by Zhao, Peng, Nairn, Alison V., Hester, Shanterian, Moremen, Kelley W., O'Regan, Ruth M., Oprea, Gabriella, Wells, Lance, Pierce, Michael, Abbott, Karen L.

“…Background: GPI-anchored proteins are elevated in breast carcinoma. Results: We utilized mass spectrometry and molecular biology techniques to capture and…”
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Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer by Abbott, Karen L, Nairn, Alison V, Hall, Erica M, Horton, Marc B, McDonald, John F, Moremen, Kelley W, Dinulescu, Daniela M, Pierce, Michael

“…Epithelial ovarian cancer is the deadliest female reproductive tract malignancy in Western countries. Less than 25% of cases are diagnosed when the cancer is…”
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Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody by Dangaj, Denarda, Abbott, Karen L, Mookerjee, Ananda, Zhao, Aizhi, Kirby, Pamela S, Sandaltzopoulos, Raphael, Powell, Jr, Daniel J, Lamazière, Antonin, Siegel, Don L, Wolf, Claude, Scholler, Nathalie

“…Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose…”
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Targeted Glycoproteomic Identification of Biomarkers for Human Breast Carcinoma by Abbott, Karen L, Aoki, Kazuhiro, Lim, Jae-Min, Porterfield, Mindy, Johnson, Rachelle, O’Regan, Ruth M, Wells, Lance, Tiemeyer, Michael, Pierce, Michael

“…Glycosylation is a dynamic post-translational modification that changes during the development and progression of various malignancies. During the oncogenesis…”
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Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb by Abbott, Karen L., Troupe, Karolyn, Lee, Intaek, Pierce, Michael

“…O-mannosyl-linked glycans constitute a third of all brain O-linked glycoproteins, and yet very little is understood about their functions. Several congenital…”
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Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers by Guo, Huabei, Abbott, Karen L

“…Changes in glycosylation have been implicated in various human diseases, including cancer. Research over the past few decades has produced significant findings…”
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Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells by Abbott, K L, Friday, B B, Thaloor, D, Murphy, T J, Pavlath, G K

“…The widely used immunosuppressant cyclosporine A (CSA) blocks nuclear translocation of the transcription factor, NF-AT (nuclear factor of activated T cells),…”
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Receptor Tyrosine Phosphatase β (RPTPβ) Activity and Signaling Are Attenuated by Glycosylation and Subsequent Cell Surface Galectin-1 Binding by Abbott, Karen L., Matthews, Russell T., Pierce, Michael

“…O-Mannosyl-linked glycosylation is abundant within the central nervous system, yet very few glycoproteins with this glycan modification have been identified…”
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Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis by Abbott, Karen L., Lim, Jae-Min, Wells, Lance, Benigno, Benedict B., McDonald, John F., Pierce, Michael

“…Epithelial ovarian cancer is diagnosed less than 25% of the time when the cancer is confined to the ovary, leading to 5‐year survival rates of less than 30%…”
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Generation of a Fully Human scFv that binds Tumor-Specific Glycoforms by Lu, Zhongpeng, Kamat, Kalika, Johnson, Blake P., Yin, Catherin C., Scholler, Nathalie, Abbott, Karen L.

“…Tumor-specific glycosylation changes are an attractive target for the development of diagnostic and therapeutic applications. Periostin is a glycoprotein with…”
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Collaborative Spirit Drives the Field of Tumor Glycobiology: A Preface to Special Volume on Cancer Glycobiology by Dimitroff, Charles J, Abbott, Karen L

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Glycomic Analysis of Membrane Glycoproteins with Bisecting Glycosylation from Ovarian Cancer Tissues Reveals Novel Structures and Functions by Allam, Heba, Aoki, Kazuhiro, Benigno, Benedict B, McDonald, John F, Mackintosh, Samuel G, Tiemeyer, Michael, Abbott, Karen L

“…Biomarkers capable of detecting and targeting epithelial ovarian cancer cells for diagnostics and therapeutics would be extremely valuable. Ovarian cancer is…”
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Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma by Murali, Pavitra, Johnson, Blake P, Lu, Zhongpeng, Climer, Leslie, Scott, Danielle A, Foulquier, Francois, Oprea-Ilies, Gabriela, Lupashin, Vladimir, Drake, Richard R, Abbott, Karen L

“…The gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation. The TMEM165 protein…”
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The clinical role of glycobiology on ovarian cancer progression by Armbrister, Rhyisa, Ochoa, Laura, Abbott, Karen L

“…Diverse carbohydrate (glycan) structures are located on lipids and proteins that cover the surface of human cells known as the glycocalyx. Research over many…”
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NMR Structure of a Complex Containing the TFIIF Subunit RAP74 and the RNA Polymerase II Carboxyl-Terminal Domain Phosphatase FCP1 by Nguyen, Bao D., Abbott, Karen L., Potempa, Krzysztof, Kobor, Michael S., Archambault, Jacques, Greenblatt, Jack, Legault, Pascale, Omichinski, James G.

“…FCP1 [transcription factor IIF (TFIIF)-associated carboxyl-terminal domain (CTD) phosphatase] is the only identified phosphatase specific for the…”
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Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin by Dolezal, Samuel, Hester, Shanterian, Kirby, Pamela S, Nairn, Allison, Pierce, Michael, Abbott, Karen L

“…The glycosylphosphatidylinositol (GPI) anchor is a glycan and lipid posttranslational modification added to proteins in the endoplasmic reticulum. Certain…”
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