Search Results - "Abbott, Derek"

Chemical Modulation of Gasdermin D Activity: Therapeutic Implications and Consequences by Zhou, Bowen, Abbott, Derek

“…The gasdermin family of proteins are central effectors of the inflammatory, lytic cell death modality known as pyroptosis. Characterized in 2015, the most…”
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Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization by Liu, Zhonghua, Wang, Chuanping, Yang, Jie, Zhou, Bowen, Yang, Rui, Ramachandran, Rajesh, Abbott, Derek W., Xiao, Tsan Sam

“…Gasdermin D (GSDMD) is an effector molecule for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways. Cleavage of GSDMD by…”
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Deep learning-based cardiovascular image diagnosis: A promising challenge by Wong, Kelvin K.L., Fortino, Giancarlo, Abbott, Derek

“…Artificial intelligence (AI) is becoming a vital concept in medicine leading to a rapid emergence of important tools for medical diagnostics. Now, as a crucial…”
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High-Sensitivity Metamaterial-Inspired Sensor for Microfluidic Dielectric Characterization by Ebrahimi, Amir, Withayachumnankul, Withawat, Al-Sarawi, Said, Abbott, Derek

“…A new metamaterial-inspired microwave microfluidic sensor is proposed in this paper. The main part of the device is a microstrip coupled complementary…”
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Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage by Liu, Zhonghua, Wang, Chuanping, Yang, Jie, Chen, Yinghua, Zhou, Bowen, Abbott, Derek W., Xiao, Tsan Sam

“…The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5, and 11 are essential steps in initiating pyroptosis after inflammasome…”
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N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis by Karmakar, Mausita, Minns, Martin, Greenberg, Elyse N., Diaz-Aponte, Jose, Pestonjamasp, Kersi, Johnson, Jennifer L., Rathkey, Joseph K., Abbott, Derek W., Wang, Kun, Shao, Feng, Catz, Sergio D., Dubyak, George R., Pearlman, Eric

“…Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma…”
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Metamaterial-based microfluidic sensor for dielectric characterization by Withayachumnankul, Withawat, Jaruwongrungsee, Kata, Tuantranont, Adisorn, Fumeaux, Christophe, Abbott, Derek

“…A microfluidic sensor is implemented from a single split-ring resonator (SRR), a fundamental building block of electromagnetic metamaterials. At resonance, an…”
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Revisiting QRS detection methodologies for portable, wearable, battery-operated, and wireless ECG systems by Elgendi, Mohamed, Eskofier, Björn, Dokos, Socrates, Abbott, Derek

“…Cardiovascular diseases are the number one cause of death worldwide. Currently, portable battery-operated systems such as mobile phones with wireless ECG…”
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Systolic peak detection in acceleration photoplethysmograms measured from emergency responders in tropical conditions by Elgendi, Mohamed, Norton, Ian, Brearley, Matt, Abbott, Derek, Schuurmans, Dale

“…Photoplethysmogram (PPG) monitoring is not only essential for critically ill patients in hospitals or at home, but also for those undergoing exercise testing…”
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Mid-infrared hybrid Si/VO2 modulator electrically driven by graphene electrodes by Sadeghi, Mehdi, Janjan, Babak, Heidari, Mohsen, Abbott, Derek

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Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity by Dorand, R. Dixon, Nthale, Joseph, Myers, Jay T., Barkauskas, Deborah S., Avril, Stefanie, Chirieleison, Steven M., Pareek, Tej K., Abbott, Derek W., Stearns, Duncan S., Letterio, John J., Huang, Alex Y., Petrosiute, Agne

“…Cancers often evade immune surveillance by adopting peripheral tissue–tolerance mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1),…”
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What is stochastic resonance? Definitions, misconceptions, debates, and its relevance to biology by McDonnell, Mark D, Abbott, Derek

“…Stochastic resonance is said to be observed when increases in levels of unpredictable fluctuations--e.g., random noise--cause an increase in a metric of the…”
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Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor by Yang, Jie, Liu, Zhonghua, Wang, Chuanping, Yang, Rui, Rathkey, Joseph K., Pinkard, Otis W., Shi, Wuxian, Chen, Yinghua, Dubyak, George R., Abbott, Derek W., Xiao, Tsan Sam

“…The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11. Recent studies identified…”
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Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models by Liu, Xia, Taftaf, Rokana, Kawaguchi, Madoka, Chang, Ya-Fang, Chen, Wenjing, Entenberg, David, Zhang, Youbin, Gerratana, Lorenzo, Huang, Simo, Patel, Dhwani B, Tsui, Elizabeth, Adorno-Cruz, Valery, Chirieleison, Steven M, Cao, Yue, Harney, Allison S, Patel, Shivani, Patsialou, Antonia, Shen, Yang, Avril, Stefanie, Gilmore, Hannah L, Lathia, Justin D, Abbott, Derek W, Cristofanilli, Massimo, Condeelis, John S, Liu, Huiping

“…Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less…”
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Tutorial: Terahertz beamforming, from concepts to realizations by Headland, Daniel, Monnai, Yasuaki, Abbott, Derek, Fumeaux, Christophe, Withayachumnankul, Withawat

“…The terahertz range possesses significant untapped potential for applications including high-volume wireless communications, noninvasive medical imaging,…”
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Human polymorphisms in GSDMD alter the inflammatory response by Rathkey, Joseph K., Xiao, Tsan S., Abbott, Derek W.

“…Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the…”
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Plasmonic Refractive Index Sensor Employing Niobium Nanofilm on Photonic Crystal Fiber by Hasan, Md Rabiul, Akter, Sanjida, Ahmed, Kawsar, Abbott, Derek

“…This letter presents a numerical investigation of a highly sensitive refractive index sensor based on surface plasmon resonance. An ultrathin niobium nanofilm…”
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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis by Rana, Nitish, Privitera, Giuseppe, Kondolf, Hannah C., Bulek, Katarzyna, Lechuga, Susana, De Salvo, Carlo, Corridoni, Daniele, Antanaviciute, Agne, Maywald, Rebecca L., Hurtado, Alexander M., Zhao, Junjie, Huang, Emina H., Li, Xiaoxia, Chan, E. Ricky, Simmons, Alison, Bamias, Giorgos, Abbott, Derek W., Heaney, Jason D., Ivanov, Andrei I., Pizarro, Theresa T.

“…Gasdermins are a family of structurally related proteins originally described for their role in pyroptosis. Gasdermin B (GSDMB) is currently the least studied,…”
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Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition by Liu, Zhonghua, Wang, Chuanping, Rathkey, Joseph K., Yang, Jie, Dubyak, George R., Abbott, Derek W., Xiao, Tsan Sam

“…Pyroptosis is an inflammatory form of programmed cell death that plays important roles in immune protection against infections and in inflammatory disorders…”
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Quasi-Photonic Crystal Fiber-Based Spectroscopic Chemical Sensor in the Terahertz Spectrum: Design and Analysis by Paul, Bikash Kumar, Ahmed, Kawsar, Vigneswaran, Dhasarathan, Ahmed, Fahad, Roy, Subrata, Abbott, Derek

“…In this paper, a novel microstructure quasi-photonic crystal fiber design is proposed. Aimed at a high relative sensitivity, it is targeted for chemical…”
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