Search Results - "Abbott, Belinda M."

A novel small molecule inhibitor of human Drp1 by Rosdah, Ayeshah A., Abbott, Belinda M., Langendorf, Christopher G., Deng, Yali, Truong, Jia Q., Waddell, Helen M. M., Ling, Naomi X. Y., Smiles, William J., Delbridge, Lea M. D., Liu, Guei-Sheung, Oakhill, Jonathan S., Lim, Shiang Y., Holien, Jessica K.

“…Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous…”
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Recent progress towards an effective treatment of amyotrophic lateral sclerosis using the SOD1 mouse model in a preclinical setting by Browne, Elisse C., Abbott, Belinda M.

“…Amyotrophic lateral sclerosis (ALS) is a progressive, fatal and incurable neurodegenerative disorder. Motor neurone degeneration can be caused by genetic…”
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The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors by Duncan, Luke F, Wang, Geqing, Ilyichova, Olga V, Scanlon, Martin J, Heras, Begoña, Abbott, Belinda M

“…A fragment-based drug discovery approach was taken to target the thiol-disulfide oxidoreductase enzyme DsbA from ( DsbA). This enzyme is critical for the…”
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Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants by Soares da Costa, Tatiana P, Hall, Cody J, Panjikar, Santosh, Wyllie, Jessica A, Christoff, Rebecca M, Bayat, Saadi, Hulett, Mark D, Abbott, Belinda M, Gendall, Anthony R, Perugini, Matthew A

“…Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with…”
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Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds by Christoff, Rebecca M, Al Bayer, Mohammad, Soares da Costa, Tatiana P, Perugini, Matthew A, Abbott, Belinda M

“…The synthesis of the first dimeric inhibitor of E. coli dihydrodipicolinate synthase (DHDPS) is reported herein. Inspired by 2,4-thiazolidinedione based…”
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A dual-target herbicidal inhibitor of lysine biosynthesis by Mackie, Emily RR, Barrow, Andrew S, Christoff, Rebecca M, Abbott, Belinda M, Gendall, Anthony R, Soares da Costa, Tatiana P

“…Herbicides with novel modes of action are urgently needed to safeguard global agricultural industries against the damaging effects of herbicide-resistant…”
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Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target by Soares da Costa, Tatiana P., Desbois, Sebastien, Dogovski, Con, Gorman, Michael A., Ketaren, Natalia E., Paxman, Jason J., Siddiqui, Tanzeela, Zammit, Leanne M., Abbott, Belinda M., Robins-Browne, Roy M., Parker, Michael W., Jameson, Geoffrey B., Hall, Nathan E., Panjikar, Santosh, Perugini, Matthew A.

“…Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the lysine biosynthesis pathway of bacteria. The pathway can be regulated by…”
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A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods by Maharani, Rani, Brownlee, Robert T.C., Hughes, Andrew B., Abbott, Belinda M.

“…[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected…”
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Exploration of 3-methylisoquinoline-4-carbonitriles as protein kinase A inhibitors of Plasmodium falciparum by Buskes, Melissa J., Harvey, Katherine L., Prinz, Boris, Crabb, Brendan S., Gilson, Paul R., Wilson, David J.D., Abbott, Belinda M.

“…[Display omitted] A series of isoquinolines have been evaluated in a homology model of Plasmodium falciparum Protein Kinase A (PfPKA) using molecular dynamics…”
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Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds by Duncan, Luke F., Wang, Geqing, Ilyichova, Olga V., Dhouib, Rabeb, Totsika, Makrina, Scanlon, Martin J., Heras, Begoña, Abbott, Belinda M.

“…[Display omitted] Bacterial thiol-disulfide oxidoreductase DsbA is essential for bacterial virulence factor assembly and has been identified as a viable…”
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Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase by Christoff, Rebecca M., Soares da Costa, Tatiana P., Bayat, Saadi, Holien, Jessica K., Perugini, Matthew A., Abbott, Belinda M.

“…[Display omitted] Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the diaminopimelate pathway for lysine biosynthesis, has…”
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Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii by Christoff, Rebecca M., Murray, Gerald L., Kostoulias, Xenia P., Peleg, Anton Y., Abbott, Belinda M.

“…[Display omitted] With multidrug resistant bacteria on the rise, novel antibiotics are becoming highly sought after. In 2008, eleven compounds were identified…”
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Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model by Richards, Benjamin J., Glab, Jason A., Mbogo, George W., Dahanayake, Darani, Smith, Brian J., Puthalakath, Hamsa, Abbott, Belinda M.

“…[Display omitted] •First example of compounds able to reduce Bim expression levels in a mouse embryonic fibroblast model.•Novel analogues have been designed…”
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A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4 by Gilson, Paul R., Kumarasingha, Rasika, Thompson, Jennifer, Zhang, Xinxin, Penington, Jocelyn Sietsma, Kalhor, Robabeh, Bullen, Hayley E., Lehane, Adele M., Dans, Madeline G., de Koning-Ward, Tania F., Holien, Jessica K., Soares da Costa, Tatiana P., Hulett, Mark D., Buskes, Melissa J., Crabb, Brendan S., Kirk, Kiaran, Papenfuss, Anthony T., Cowman, Alan F., Abbott, Belinda M.

“…We developed a novel series of antimalarial compounds based on a 4-cyano-3-methylisoquinoline. Our lead compound MB14 achieved modest inhibition of the growth…”
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Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors by O’Brien, Nathan J., Brzozowski, Martin, Wilson, David J.D., Deady, Leslie W., Abbott, Belinda M.

“…PDK1 is an important regulator of the PI3K/Akt pathway, which has been found frequently activated in a large number of human cancers. Herein we described the…”
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Synthesis and effects of conjugated tocopherol analogues on peptide nucleic acid hybridisation by Browne, Elisse C, Langford, Steven J, Abbott, Belinda M

“…To the N-terminus of a nonamer peptide nucleic acid sequence, H-GCACGACTT-NH2, was attached a number of lipophilic conjugate molecules including three…”
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Pursuing DHDPS: an enzyme of unrealised potential as a novel antibacterial target by Christoff, Rebecca M, Gardhi, Chamodi K, Soares da Costa, Tatiana P, Perugini, Matthew A, Abbott, Belinda M

“…Antibiotic resistance is only set to increase if significant action is not taken to combat the imminent threat of multidrug resistant pathogens. The…”
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Molecular evolution of an oligomeric biocatalyst functioning in lysine biosynthesis by Soares da Costa, Tatiana P., Abbott, Belinda M., Gendall, Anthony R., Panjikar, Santosh, Perugini, Matthew A.

“…Dihydrodipicolinate synthase (DHDPS) is critical to the production of lysine through the diaminopimelate (DAP) pathway. Elucidation of the function, regulation…”
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Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors by O’Brien, Nathan J., Brzozowski, Martin, Buskes, Melissa J., Deady, Leslie W., Abbott, Belinda M.

“…PDK1, a biological target that has attracted a large amount of attention recently, is responsible for the positive regulation of the PI3K/Akt pathway that is…”
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Efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis by Browne, Elisse C., Parakh, Sonam, Duncan, Luke F., Langford, Steven J., Atkin, Julie D., Abbott, Belinda M.

“…[Display omitted] Cellular studies have been undertaken on a nonamer peptide nucleic acid (PNA) sequence, which binds to mRNA encoding superoxide dismutase 1,…”
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