Search Results - "Abbasi, Shawn A."
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Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
Published in Science (American Association for the Advancement of Science) (04-09-2020)“…The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate…”
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Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
Published in Science (American Association for the Advancement of Science) (04-06-2021)“…The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following SARS-CoV-2 infection are…”
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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition
Published in Cell host & microbe (09-09-2020)“…There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the…”
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Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19
Published in Frontiers in immunology (01-06-2022)“…COVID-19 emergency use authorizations and approvals for vaccines were achieved in record time. However, there remains a need to develop additional safe,…”
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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies
Published in PLoS pathogens (11-04-2024)“…Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as…”
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