The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19

The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19

Background Excessive inflammation has been implicated in the immunopathogenesis of coronavirus disease 2019 (COVID-19). In the current study, the involvement of S100 calcium binding protein S100A4, S100A9, and S100A10 in the inflammatory settings of COVID-19 patients were evaluated. Methods Peripher...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation research Vol. 71; no. 3; pp. 369 - 376
Main Authors: Bagheri-Hosseinabadi, Zahra, Abbasi, Mohadese, Kahnooji, Mahmood, Ghorbani, Zainab, Abbasifard, Mitra
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-03-2022
Subjects:
Adult
Aged
Allergology
Annexin A2 - genetics
Biomedical and Life Sciences
Biomedicine
Calgranulin B - genetics
COVID-19 - blood
COVID-19 - genetics
Dermatology
Female
Humans
Immunology
Male
Middle Aged
Neurology
Original
Original Research Article
Pharmacology/Toxicology
Prognosis
Rheumatology
RNA, Messenger - blood
S100 Calcium-Binding Protein A4 - genetics
S100 Proteins - genetics
SARS-CoV-2
Severity of Illness Index
Inflammation
S100A4
Coronavirus disease 2019
S100A9
S100A10
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Excessive inflammation has been implicated in the immunopathogenesis of coronavirus disease 2019 (COVID-19). In the current study, the involvement of S100 calcium binding protein S100A4, S100A9, and S100A10 in the inflammatory settings of COVID-19 patients were evaluated. Methods Peripheral blood samples were obtained from 65 COVID-19 subjects and 50 healthy controls. From the blood samples, RNA was extracted and cDNA was synthesized, and then the mRNA expression levels of S100A4, S100A9, and S100A10 were measured by Real-time PCR. Results The mRNA expression of S100A4 (fold change [FC] = 1.45, P  = 0.0011), S100A9 (FC = 1.47, P  = 0.0013), and S100A10 (FC = 1.35, P  = 0.0053) was significantly upregulated in COVID-19 patients than controls. The mRNA expression of S100A4 (FC = 1.43, P  = 0.0071), (FC = 1.66, P  = 0.0001), and S100A10 (FC = 1.63, P  = 0.0003) was significantly upregulated in the severe COVID-19 subjects than mild-to-moderate subjects. There was a significant positive correlation between mRNA expression of S100A4 ( ρ  = 0.49, P  = 0.030), S100A9 ( ρ  = 0.55, P  = 0.009), and S100A10 ( ρ  = 0.39, P  = 0.040) and d -dimer in the COVID-19 patients. The AUC for S100A4, S100A9, and S100A10 mRNAs were 0.79 (95% CI 0.66–0.92, P  = 0.004), 0.80 (95% CI 0.67–0.93, P  = 0.002), and 0.71 (95% CI 0.56–0.85, P  = 0.010), respectively. Conclusions S100A4, S100A9, and S100A10 play a role in the inflammatory conditions in COVID-19 patients and have potential in prognosis of severe form of COVID-19. Targeting these modules, hopefully, might confer a therapeutic tool in preventing sever symptoms in the COVID-19 patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Responsible Editor: John Di Battista.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-022-01545-7