Search Results - "Abbas Bukhari, Syed Nasir"

Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease by Karimi Askarani, Hajar, Iraji, Aida, Rastegari, Arezoo, Abbas Bukhari, Syed Nasir, Firuzi, Omidreza, Akbarzadeh, Tahmineh, Saeedi, Mina

“…To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and…”
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A review: Biologically active 3,4-heterocycle-fused coumarins by Salehian, Fatemeh, Nadri, Hamid, Jalili-Baleh, Leili, Youseftabar-Miri, Leila, Abbas Bukhari, Syed Nasir, Foroumadi, Alireza, Tüylü Küçükkilinç, Tuba, Sharifzadeh, Mohammad, Khoobi, Mehdi

“…The combination of heterocycles offers a new opportunity to create novel multicyclic compounds having improved biological activity. Coumarins are ubiquitous…”
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Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective by Saleem, Sumaira, Muhammad, Gulzar, Hussain, Muhammad Ajaz, Altaf, Muhammad, Bukhari, Syed Nasir Abbas

“…L. is a multipurpose medicinal plant of family occurring abundantly in sub-tropical regions of the world. The folk healers used the plant to treat several…”
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Synthesis and biological evaluation of chalcone derivatives (mini review) by Bukhari, Syed Nasir Abbas, Jasamai, Malina, Jantan, Ibrahim

“…Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. A three carbon α, β-unsaturated carbonyl system constitutes…”
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Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors by Abdelbaset, Mahmoud S., Abdel-Aziz, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Abbas Bukhari, Syed Nasir, Ali, Taha F.S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
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Co-Combination of Pregabalin and Withania coagulans -Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model by Asghar, Anam, Aamir, Muhammad Naeem, Sheikh, Fatima Akbar, Ahmad, Naveed, Elsherif, Mervat A, Abbas Bukhari, Syed Nasir

“…The current study reports the fabrication of co-combination gel using Pregabalin and Withania coagulans fruit extract to validate its effectiveness for…”
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Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach by Janković, Nenad, Tadić, Julijana, Milović, Emilija, Marković, Zoran, Jeremić, Svetlana, Petronijević, Jelena, Joksimović, Nenad, Borović, Teona Teodora, Abbas Bukhari, Syed Nasir

“…Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells…”
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Anti-inflammatory trends of 1, 3-diphenyl-2-propen-1-one derivatives by Bukhari, Syed Nasir Abbas, Jantan, Ibrahim, Jasamai, Malina

“…Chalcones (1, 3-Diphenyl-2-propen-1-one) are constituted by a three carbon α, β-unsaturated carbonyl system. The biosynthesis of flavonoids and isoflavonoids…”
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Identification of potent aldose reductase inhibitors as antidiabetic (Anti-hyperglycemic) agents using QSAR based virtual Screening, molecular Docking, MD simulation and MMGBSA approaches by Bakal, Ravindra L., Jawarkar, Rahul D., Manwar, J.V., Jaiswal, Minal S., Ghosh, Arabinda, Gandhi, Ajaykumar, Zaki, Magdi E.A., Al-Hussain, Sami, Samad, Abdul, Masand, Vijay H., Mukerjee, Nobendu, Nasir Abbas Bukhari, Syed, Sharma, Praveen, Lewaa, Israa

“…The aldose reductase (AR) enzyme is an important target enzyme in the development of therapeutics against hyperglycaemia induced health complications such as…”
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Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy by Alam, Javaid, Jantan, Ibrahim, Bukhari, Syed Nasir Abbas

“…Abstract An autoimmune disease is defined as a clinical syndrome resulted from an instigation of both T cell and B cell or individually, in the absence of any…”
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Effects of berberine on intestinal flora of Non-alcoholic fatty liver induced by High-fat diet through 16S rRNA gene segmentation by Wang, Yuzhen, Zheng, Jimin, Hou, Hongtao, Zhang, Jian, Qi, Shuangfei, Li, Yueqin, Hadal Alotaibi, Nasser, Saad Alharbi, Khalid, Nasir Abbas Bukhari, Syed

“…Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome, which has become one of the globally recognized threats to health in…”
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Formulation and optimization of levofloxacin loaded chitosan nanoparticle for ocular delivery: In-vitro characterization, ocular tolerance and antibacterial activity by Ameeduzzafar, Imam, Syed Sarim, Abbas Bukhari, Syed Nasir, Ahmad, Javed, Ali, Asgar

“…In this study, chitosan nanoparticles (CH-NPs) were used to encapsulate antibacterial agent levofloxacin for the treatment of ocular infection. The chitosan…”
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Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials by Jantan, Ibrahim, Ahmad, Waqas, Bukhari, Syed Nasir Abbas

“…The phagocyte-microbe interactions in the immune system is a defense mechanism but when excessively or inappropriately deployed can harm host tissues and…”
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Current prospects of synthetic curcumin analogs and chalcone derivatives against mycobacterium tuberculosis by Bukhari, Syed Nasir Abbas, Franzblau, Scott G, Jantan, Ibrahim, Jasamai, Malina

“…Tuberculosis, caused by Mycobacterium tuberculosis, is amongst the foremost infectious diseases. Treatment of tuberculosis is a complex process due to various…”
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Synthesis and evaluation of new chalcones and oximes as anticancer agents by Bukhari, Syed Nasir Abbas

“…Complex illnesses, such as cancer, are often caused by many disorders, gene mutations, or pathways. Biological pathways play a significant part in the…”
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Emerging Nanotherapeutic Approaches to Overcome Drug Resistance in Cancers with Update on Clinical Trials by Bukhari, Syed Nasir Abbas

“…A key issue with modern cancer treatments is the emergence of resistance to conventional chemotherapy and molecularly targeted medicines. Cancer…”
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Dietary Polyphenols as Therapeutic Intervention for Alzheimer's Disease: A Mechanistic Insight by Bukhari, Syed Nasir Abbas

“…Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc…”
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Tinospora species: An overview of their modulating effects on the immune system by Haque, Md. Areeful, Jantan, Ibrahim, Abbas Bukhari, Syed Nasir

“…Studies on the effects of natural immunomodulators to heal various diseases related to the immune system have been a growing interest in recent years. Amongst…”
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A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease by Jalili-Baleh, Leili, Babaei, Elaheh, Abdpour, Shahin, Nasir Abbas Bukhari, Syed, Foroumadi, Alireza, Ramazani, Ali, Sharifzadeh, Mohammad, Abdollahi, Mohammad, Khoobi, Mehdi

“…Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including…”
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A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica by Saleem, Sumaira, Muhammad, Gulzar, Hussain, Muhammad Ajaz, Bukhari, Syed Nasir Abbas

“…Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of…”
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