Search Results - "Abbas, Samar H."

Recent updates of fluoroquinolones as antibacterial agents by Ezelarab, Hend A. A., Abbas, Samar H., Hassan, Heba A., Abuo‐Rahma, Gamal El‐Din A.

“…Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria…”
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New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity by Abbas, Samar H., Abd El-Hafeez, Amer Ali, Shoman, Mai E., Montano, Monica M., Hassan, Heba A.

“…[Display omitted] •Synthesis of quinoline chalcone hybrids.•NCI screening of synthesized compounds.•Cytotoxicity evaluation.•Evaluation of PI3k…”
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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization by Mohammed, Hamada H. H., Abd El-Hafeez, Amer Ali, Ebeid, Kareem, Mekkawy, Aml I., Abourehab, Mohammed A. S., Wafa, Emad I., Alhaj-Suliman, Suhaila O., Salem, Aliasger K., Ghosh, Pradipta, Abuo-Rahma, Gamal El-Din A., Hayallah, Alaa M., Abbas, Samar H.

“…A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable…”
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Design, synthesis, and biological investigation of quinoline/ciprofloxacin hybrids as antimicrobial and anti-proliferative agents by Ezelarab, Hend A. A., Hassan, Heba A., Abuo-Rahma, Gamal El-Din A., Abbas, Samar H.

“…Ciprofloxacin-Piperazine C-7 linked quinoline derivatives 6a–c and 8a–c were synthesized and investigated for their antibacterial, antifungal, and…”
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New antiproliferative 7-(4-(N-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2/M phase by Mohammed, Hamada H.H., Abd El-Hafeez, Amer Ali, Abbas, Samar H., Abdelhafez, El-Shimaa M.N., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •New N-4 piperazinyl derivatives of ciprofloxacin.•Cytotoxic activity against different cancer cell lines especially non-small cell lung…”
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Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Hassan, Heba A., Beshr, Eman A. M.

“…Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML)…”
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Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV600E by Hagar, Fatma Fouad, Abbas, Samar H., Gomaa, Hesham A. M., Youssif, Bahaa G. M., Sayed, Ahmed M., Abdelhamid, Dalia, Abdel-Aziz, Mohamed

“…Introduction One of the most robust global challenges and difficulties in the 21st century is cancer. Treating cancer is a goal which continues to motivate…”
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Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives by Mohammed, Hamada H. H., Abbas, Samar H., Abdelhafez, El-Shimaa M. N., Berger, James M., Mitarai, Satoshi, Arai, Masayoshi, Abuo-Rahma, Gamal El-Din A. A.

“…Herein we report the synthesis of new N -4-piperazinyl thiadiazole and oxadiazole ciprofloxacin derivatives and their antibacterial and antimycobacterial…”
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New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells by Ahmed, Fatma F., Abd El-Hafeez, Amer Ali, Abbas, Samar H., Abdelhamid, Dalia, Abdel-Aziz, Mohamed

“…A series of novel 1, 2, 4-triazole/chalcone hybrids was prepared and identified with different spectroscopic techniques. The prepared compounds showed…”
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Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016-2023) by Hagar, Fatma Fouad, Abbas, Samar H, Atef, Eman, Abdelhamid, Dalia, Abdel-Aziz, Mohamed

“…Benzimidazole scaffolds have potent anticancer activity due to their structure similarity to nucleoside. In addition, benzimidazoles could function as hydrogen…”
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Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review by Mansour, Mostafa A, AboulMagd, Asmaa M, Abbas, Samar H, Abdel-Rahman, Hamdy M, Abdel-Aziz, Mohamed

“…Lung cancer is the second most common cause of morbidity and mortality among cancer types worldwide, with non-small cell lung cancer (NSCLC) representing the…”
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Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy by Badran, Mostafa M., Abbas, Samar H., Tateishi, Hiroshi, Maemoto, Yuki, Toma, Tsugumasa, Ito, Akihiro, Fujita, Mikako, Otsuka, Masami, Abdel-Aziz, Mohamed, Radwan, Mohamed O.

“…The relentless pursuit of novel therapeutic agents against cancer has led to the identification of multiple molecular targets, among which Sirtuin 2 (SIRT2)…”
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1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities by Fathi, Marwa Ali A., Abd El-Hafeez, Amer Ali, Abdelhamid, Dalia, Abbas, Samar H., Montano, Monica M., Abdel-Aziz, Mohamed

“…[Display omitted] •New 1,3,4-Oxadiazole/Chalcone hybrids 8a-x were synthesized.•Compounds 8a, 8g, 8n, 8p, 8s and 8v had shown the highest cytotoxicity against…”
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Harnessing pyrimidine as a building block for histone deacetylase inhibitors by Badran, Mostafa M, Abbas, Samar H, Fujita, Mikako, Abdel-Aziz, Mohamed

“…Histone deacetylase (HDAC) inhibitors are well-established multifaceted bioactive agents against tumors and neurodegenerative disorders. Pyrimidine and its…”
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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization by Ezelarab, Hend A. A., Ali, Taha F. S., Abbas, Samar H., Sayed, Ahmed M., Beshr, Eman A. M., Hassan, Heba A.

“…New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative agents. The antiproliferative activity of compounds 6a–j was…”
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New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents by Hagar, Fatma Fouad, Abbas, Samar H., Abdelhamid, Dalia, Gomaa, Hesham A. M., Youssif, Bahaa G. M., Abdel‐Aziz, Mohamed

“…A series of new 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids 9a–o and 10a–k were designed and synthesized as potential antiproliferative agents. Hybrids…”
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Quinazoline‐chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in‐silico studies of potential anticancer activity against multiple myeloma by Mansour, Mostafa A., AboulMagd, Asmaa M., Abbas, Samar H., Abdel‐Aziz, Mohamed, Abdel‐Rahman, Hamdy M.

“…Two new series of quinazoline‐chalcone hybrids were designed, synthesized as histone deacetylase (HDAC)/epidermal growth factor receptor (EGFR) dual…”
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New 2-oxoindole derivatives as multiple PDGFRα/ß and VEGFR-2 tyrosine kinase inhibitors by Ezelarab, Hend A.A., Abd El-Hafeez, Amer Ali, Ali, Taha F.S., Sayed, Ahmed M., Hassan, Heba A., Beshr, Eman A.M., Abbas, Samar H.

“…[Display omitted] •Two series based 2-oxoindole derivatives. N-aryl acetamides 6a-o having amide linker and its isoster benzyloxy benzylidenes 9a-p were…”
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Novel urea linked ciprofloxacin-chalcone hybrids having antiproliferative topoisomerases I/II inhibitory activities and caspases-mediated apoptosis by Mohammed, Hamada H.H., Abbas, Samar H., Hayallah, Alaa M., Abuo-Rahma, Gamal El-Din A., Mostafa, Yaser A.

“…[Display omitted] •Novel urea linked ciprofloxacin-chalcone hybrids 3a-j.•3c and 3j showed remarkable cytotoxicity against HCT-116 and leukemia-SR…”
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Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors by Mohammed, Hamada H. H., Ali, Doaa Mohamed Elroby, Badr, Mohamed, Habib, Ahmed G. K., Mahmoud, Abobakr Mohamed, Farhan, Sarah M., Gany, Shimaa Salah Hassan Abd El, Mohamad, Soad A., Hayallah, Alaa M., Abbas, Samar H., Abuo-Rahma, Gamal El-Din A.

“…A series of N -4 piperazinyl ciprofloxacin derivatives as urea-tethered ciprofloxacin-chalcone hybrids 2a-j and thioacetyl-linked ciprofloxacin-pyrimidine…”
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