Search Results - "Abbas, Safinaz E"

Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors by Farouk, Ahmed K.B.A.W., Abdelrasheed Allam, Heba, Rashwan, Essam, George, Riham F., Abbas, Safinaz E-S.

“…[Display omitted] •The synthesis of new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines.•Seventeen of the target compounds were evaluated as dual EGFR/HER2…”
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4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity by Abbas, Safinaz E.-S., Aly, Enayat I., Awadallah, Fadi M., Mahmoud, Walaa R.

“…Four series of some 4‐substituted‐1‐phenyl‐1H‐pyrazolo[3,4‐d]pyrimidine derivatives 5a–f, 6a–f, 8a–f, and 9a–f were designed to be screened for their antitumor…”
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Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors by Oudah, Khulood H., Mahmoud, Walaa R., Awadallah, Fadi M., Taher, Azza T., Abbas, Safinaz E.-S, Allam, Heba Abdelrasheed, Vullo, Daniela, Supuran, Claudiu T.

“…The present investigation reports the design and synthesis of three series of benzoylthioureido derivatives bearing either benzenesulfonamide 7a-f, benzoic…”
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Design, synthesis, and molecular docking of novel indole scaffold‐based VEGFR‐2 inhibitors as targeted anticancer agents by Roaiah, Hanaa M., Ghannam, Iman A. Y., Ali, Islam H., El Kerdawy, Ahmed M., Ali, Mamdouh M., Abbas, Safinaz E‐S., El‐Nakkady, Sally S.

“…A series of new indole derivatives 1–18 was synthesized and tested for their cytotoxic activity on a panel of 60 tumor cell lines. Additionally, molecular…”
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Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes by Najm, Mazin A. A., Mahmoud, Walaa R., Taher, Azza T., Abbas, Safinaz E-S., Awadallah, Fadi M., Allam, Heba Abdelrasheed, Vullo, Daniela, Supuran, Claudiu T.

“…The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the…”
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Design, Synthesis, and Biological Evaluation of Some Cyclohepta[b]Thiophene and Substituted Pentahydrocycloheptathieno[2,3‐d]Pyrimidine Derivatives by Elmongy, Elshaymaa I., Khedr, Mohammed A., Taleb, Nageh A., Awad, Hanem M., Abbas, Safinaz E.‐S.

“…This investigation describes the design of a series of cycloheptathieno[2,3‐d]pyrimidines along with their synthetic strategy. The target compounds were…”
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Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest by Fares, Mohamed, Abou-Seri, Sahar Mahmoud, Abdel-Aziz, Hatem A., Abbas, Safinaz E.-S., Youssef, Mohieldin Magdy, Eladwy, Radwa Ahmed

“…New series of 2-(2-arylidenehydrazinyl)pyrido[2,3-d]pyrimidines 5a–e and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidines 6–15 were synthesized and evaluated for…”
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Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors by George, Riham F., Samir, Eman M., Abdelhamed, Mennatullah N., Abdel-Aziz, Hatem A., Abbas, Safinaz E-S.

“…The quinolinyl/pyrazolinyl thiazole hybrid 6b exhibited promising anti-proliferative activity against MCF-7 (breast), HeLa (cervical) and DLD1(colon) cancer…”
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HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability by Elwaie, Tamer A, Abbas, Safinaz E, Aly, Enayat I, George, Riham F, Ali, Hamdy, Kraiouchkine, Nikolai, Abdelwahed, Khaldoun S, Fandy, Tamer E, El Sayed, Khalid A, Abd Elmageed, Zakaria Y, Ali, Hamed I

“…HER2 kinase as a well-established target for breast cancer (BC) therapy is associated with aggressive clinical outcomes; thus, herein we present structural…”
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Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives by Awadallah, Fadi M., El-Waei, Tamer A., Hanna, Mona M., Abbas, Safinaz E., Ceruso, Mariangela, Oz, Beyza Ecem, Guler, Ozen Ozensoy, Supuran, Claudiu T.

“…Four series of sulfonamides incorporating chromone moieties were synthesized and assessed for their cytotoxic activity against MCF-7 and A-549 cell lines,…”
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New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies by Abbas, Safinaz E., Awadallah, Fadi M., Ibrahin, Nashwa A., Said, Eman G., Kamel, Gihan M.

“…Two groups of hybrid compounds: the quinazolinone–dihydropyrimidines and quinazolinone–pyrimidines, were synthesized. The starting derivative 3 was reacted…”
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Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives by Abbas, Safinaz E., Abdel Gawad, Nagwa M., George, Riham F., Akar, Yahya A.

“…Two series of new tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines namely 2,3-disubstituted derivatives 3a–z and 2,4-disubstituted ones 6a–c were prepared and…”
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Design and synthesis of novel imidazo[4,5-b]pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity by Ghanem, Nada M., Farouk, Faten, George, Riham F., Abbas, Safinaz E.S., El-Badry, Ossama M.

“…[Display omitted] •New imidazo[4,5-b]pyridine derivatives were designed and synthesized.•The new derivatives had remarkable anti-proliferative…”
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Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies by ABBAS, Safinaz E, AWADALLAH, Fadi M, IBRAHIM, Nashwa A, GOUDA, Ahmed M

“…Synthesis of several substituted pyrrolizines 10a-f, 11a-f, 13a-c, pyrimidopyrrolizines 14a-c, 15a-c, and pyrrolizinopyrimidoisoindoles 12a-c was discussed…”
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Synthesis and antitumor activity of certain 2,3,6-trisubstituted quinazolin-4(3H)-one derivatives by Abbas, Safinaz E., Barsoum, Flora F., Georgey, Hanan H., Mohammed, Eman R.

“…The manuscript deals with the synthesis of 6-iodo-2-phenoxymethyl 3-substituted quinazolin-4(3H)-one derivatives. The obtained compounds were evaluated for…”
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Some 2-(4-bromophenoxymethyl)-6-iodo-3-substituted quinazolin-4(3H)ones: Synthesis, cytotoxic activity, EGFR inhibition and molecular docking by Abbas, Safinaz E-S., Abdel-Gawad, Nagwa M., George, Riham F., Elyazid, Mohamed G. Abu, Zaater, Marwa A., El-Ashrey, Mohamed K.

“…•Some 2,3,6-trisubstituted quinazoline-4(3H)ones were prepared.•They were tested for their cytotoxicity against 3 cancer cell lines.•Many compounds revealed…”
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Synthesis and anticancer activity of some pyrido[2,3- d ]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors by Abbas, Safinaz E-S, George, Riham F, Samir, Eman M, Aref, Mostafa Ma, Abdel-Aziz, Hatem A

“…Due to emergence of resistance to available anticancer agents, there is a need to search for new cytotoxic agents. Pyrido[2,3- ]pyrimidines ( - ) and their…”
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4‐Substituted‐1‐phenyl‐1 H ‐pyrazolo[3,4‐ d ]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity by Abbas, Safinaz E.‐S., Aly, Enayat I., Awadallah, Fadi M., Mahmoud, Walaa R.

“…Four series of some 4‐substituted‐1‐phenyl‐1 H ‐pyrazolo[3,4‐ d ]pyrimidine derivatives 5a – f , 6a – f , 8a – f , and 9a – f were designed to be screened for…”
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Design, synthesis and preliminary evaluation of some novel [1,4]diazepino [5,6-b]pyrrolizine and 6-(2-oxopyrrolidino)-1H-pyrrolizine derivatives as anticonvulsant agents by Abbas, Safinaz E., Awadallah, Fadi Mohsen, Ibrahim, Nashwa A., Gouda, Ahmed M., Shehata, Bassem A.

“…New series of diazepino[5,6- b ]pyrrolizines 7a – c and 8a – c and 6-(2-oxopyrrolidino)-1 H -pyrrolizines 10a – c were synthesized through acylation of the key…”
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