Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)

To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors su...

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Published in:	World journal of emergency surgery Vol. 10; no. 57; p. 61
Main Authors:	Sartelli, Massimo, Abu-Zidan, Fikri M, Catena, Fausto, Griffiths, Ewen A, Di Saverio, Salomone, Coimbra, Raul, Ordoñez, Carlos A, Leppaniemi, Ari, Fraga, Gustavo P, Coccolini, Federico, Agresta, Ferdinando, Abbas, Asrhaf, Abdel Kader, Saleh, Agboola, John, Amhed, Adamu, Ajibade, Adesina, Akkucuk, Seckin, Alharthi, Bandar, Anyfantakis, Dimitrios, Augustin, Goran, Baiocchi, Gianluca, Bala, Miklosh, Baraket, Oussama, Bayrak, Savas, Bellanova, Giovanni, Beltràn, Marcelo A, Bini, Roberto, Boal, Matthew, Borodach, Andrey V, Bouliaris, Konstantinos, Branger, Frederic, Brunelli, Daniele, Catani, Marco, Che Jusoh, Asri, Chichom-Mefire, Alain, Cocorullo, Gianfranco, Colak, Elif, Costa, David, Costa, Silvia, Cui, Yunfeng, Curca, Geanina Loredana, Curry, Terry, Das, Koray, Delibegovic, Samir, Demetrashvili, Zaza, Di Carlo, Isidoro, Drozdova, Nadezda, El Zalabany, Tamer, Enani, Mushira Abdulaziz, Faro, Mario, Gachabayov, Mahir, Giménez Maurel, Teresa, Gkiokas, Georgios, Gomes, Carlos Augusto, Gonsaga, Ricardo Alessandro Teixeira, Guercioni, Gianluca, Guner, Ali, Gupta, Sanjay, Gutierrez, Sandra, Hutan, Martin, Ioannidis, Orestis, Isik, Arda, Izawa, Yoshimitsu, Jain, Sumita A, Jokubauskas, Mantas, Karamarkovic, Aleksandar, Kauhanen, Saila, Kaushik, Robin, Kenig, Jakub, Khokha, Vladimir, Kim, Jae Il, Kong, Victor, Koshy, Renol, Krasniqi, Avidyl, Kshirsagar, Ashok, Kuliesius, Zygimantas, Lasithiotakis, Konstantinos, Leão, Pedro, Lee, Jae Gil, Leon, Miguel, Lizarazu Pérez, Aintzane, Lohsiriwat, Varut, López-Tomassetti Fernandez, Eudaldo, Lostoridis, Eftychios, Mn, Raghuveer, Major, Piotr, Marinis, Athanasios, Marrelli, Daniele, Martinez-Perez, Aleix, Marwah, Sanjay, McFarlane, Michael, Melo, Renato Bessa, Mesina, Cristian, Michalopoulos, Nick, Moldovanu, Radu, Mouaqit, Ouadii, Munyika, Akutu, Negoi, Ionut, Nikolopoulos, Ioannis, Nita, Gabriela Elisa
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 16-12-2015 BioMed Central
Subjects:	Abdomen Abscess Health aspects Immunotherapy Sepsis Septic shock Infections Intra-abdominal
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Summary:	To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1749-7922 1749-7922
DOI:	10.1186/s13017-015-0055-0