Search Results - "Abbas, Abul K"

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases by Klatzmann, David, Abbas, Abul K.

“…Key Points Interleukin-2 (IL-2) was discovered as a cytokine that supports the proliferation and differentiation of effector T cells. IL-2 initially entered…”
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Revisiting IL-2: Biology and therapeutic prospects by Abbas, Abul K, Trotta, Eleonora, R Simeonov, Dimitre, Marson, Alexander, Bluestone, Jeffrey A

“…Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell growth factor essential for the proliferation of T cells and the…”
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A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes by Scharschmidt, Tiffany C., Vasquez, Kimberly S., Truong, Hong-An, Gearty, Sofia V., Pauli, Mariela L., Nosbaum, Audrey, Gratz, Iris K., Otto, Michael, Moon, James J., Liese, Jan, Abbas, Abul K., Fischbach, Michael A., Rosenblum, Michael D.

“…The skin is a site of constant dialog between the immune system and commensal bacteria. However, the molecular mechanisms that allow us to tolerate the…”
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Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair by Mathur, Anubhav N., Zirak, Bahar, Boothby, Ian C., Tan, Madge, Cohen, Jarish N., Mauro, Thea M., Mehta, Pooja, Lowe, Margaret M., Abbas, Abul K., Ali, Niwa, Rosenblum, Michael D.

“…Restoration of barrier-tissue integrity after injury is dependent on the function of immune cells and stem cells (SCs) residing in the tissue. In response to…”
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IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells by Penaranda, Cristina, Kuswanto, Wilson, Hofmann, Jerry, Kenefeck, Rupert, Narendran, Parth, Walker, Lucy S. K., Blueston, Jeffrey A., Abbas, Abul K., Dooms, Hans

“…To protect the organism against autoimmunity, self-reactive effector/memory T cells (TE/M) are controlled by cell-intrinsic and -extrinsic regulatory…”
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A Resource for the Conditional Ablation of microRNAs in the Mouse by Park, Chong Yon, Jeker, Lukas T., Carver-Moore, Karen, Oh, Alyssia, Liu, Huey Jiin, Cameron, Rachel, Richards, Hunter, Li, Zhongmei, Adler, David, Yoshinaga, Yuko, Martinez, Maria, Nefadov, Michael, Abbas, Abul K., Weiss, Art, Lanier, Lewis L., de Jong, Pieter J., Bluestone, Jeffrey A., Srivastava, Deepak, McManus, Michael T.

“…The importance of miRNAs during development and disease processes is well established. However, most studies have been done in cells or with patient tissues,…”
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Paths to understanding the genetic basis of autoimmune disease by Rioux, John D, Abbas, Abul K

“…Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their…”
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The Surprising Story of IL-2: From Experimental Models to Clinical Application by Abbas, Abul K

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Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes Off by Van Parijs, Luk, Abbas, Abul K.

“…The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms…”
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Regulatory T cell memory by Rosenblum, Michael D., Way, Sing Sing, Abbas, Abul K.

“…Key Points Memory lymphocytes have an indispensable role in eradicating pathogens. They mediate their effects by responding more robustly with repeated…”
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Chance and Opportunity: A Personal Story by Abbas, Abul K

“…This article summarizes my personal life story, from early education in India to research, teaching, and other activities in Boston and San Francisco. I have…”
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Mechanisms of human autoimmunity by Rosenblum, Michael D, Remedios, Kelly A, Abbas, Abul K

“…Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and…”
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Duration of antigen receptor signaling determines T-cell tolerance or activation by Katzman, Shoshana D., O’Gorman, William E., Villarino, Alejandro V., Gallo, Eugenio, Friedman, Rachel S., Krummel, Matthew F., Nolan, Garry P., Abbas, Abul K., Weiss, Arthur

“…The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen…”
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Opposing functions of IL-2 and IL-7 in the regulation of immune responses by Katzman, Shoshana D., Hoyer, Katrina K., Dooms, Hans, Gratz, Iris K., Rosenblum, Michael D., Paw, Jonathan S., Isakson, Sara H., Abbas, Abul K.

“…► IL-2 is involved in the generation of an immune response, driving the proliferation and generation of effector T cells. ► IL-2 is involved in the regulation…”
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CD4+CD25+ Cells Controlling a Pathogenic CD4 Response Inhibit Cytokine Differentiation, CXCR-3 Expression, and Tissue Invasion by Sarween, Nadia, Chodos, Anna, Raykundalia, Chandra, Khan, Mahmood, Abbas, Abul K, Walker, Lucy S. K

“…It is well established that CD4(+)CD25(+) regulatory T cells (Tregs) inhibit autoimmune pathology. However, precisely how the behavior of disease-inducing T…”
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Differential requirements for Th1 and Th17 responses to a systemic self-antigen by Katzman, Shoshana D, Gallo, Eugenio, Hoyer, Katrina K, Abbas, Abul K

“…T cell-APC interactions are essential for the initiation of effector responses against foreign and self-antigens, but the role of these interactions in…”
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Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing by Nosbaum, Audrey, Prevel, Nicolas, Truong, Hong-An, Mehta, Pooja, Ettinger, Monika, Scharschmidt, Tiffany C, Ali, Niwa H, Pauli, Mariela L, Abbas, Abul K, Rosenblum, Michael D

“…Foxp3-expressing regulatory T cells (Tregs) reside in tissues where they control inflammation and mediate tissue-specific functions. The skin of mice and…”
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Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation by Ali, Niwa, Zirak, Bahar, Rodriguez, Robert Sanchez, Pauli, Mariela L., Truong, Hong-An, Lai, Kevin, Ahn, Richard, Corbin, Kaitlin, Lowe, Margaret M., Scharschmidt, Tiffany C., Taravati, Keyon, Tan, Madeleine R., Ricardo-Gonzalez, Roberto R., Nosbaum, Audrey, Bertolini, Marta, Liao, Wilson, Nestle, Frank O., Paus, Ralf, Cotsarelis, George, Abbas, Abul K., Rosenblum, Michael D.

“…The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of…”
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Interleukin-2 in the development and control of inflammatory disease by Hoyer, Katrina K, Dooms, Hans, Barron, Luke, Abbas, Abul K

“…Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1…”
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Role of T cells in a murine model of Escherichia coli sepsis by van Schaik, Sandrijn M, Abbas, Abul K

“…To study the role of T cells in gram-negative sepsis, we developed a mouse model in which i.v. injection of Escherichia coli results in severe systemic…”
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