Role of tumor necrosis factor-like weak inducer of apoptosis / fibroblast growth factor-inducible molecule 14 pathway in lupus nephritis
Objectives To evaluate urinary tumor necrosis factor-like weak inducer of apoptosis (uTWEAK) levels as well as renal fibroblast growth factor-inducible molecule 14 (Fn14) expression by immunohistochemistry in patients with systemic lupus erythematosus (SLE) to assess the possible role of TWEAK level...
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| Published in: | Egyptian Rheumatology and Rehabilitation Vol. 45; no. 4; pp. 182 - 187 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cairo, Egypt
The Egyptian Society for Rheumatology and Rehabilitation
01-10-2018
Springer Berlin Heidelberg Wolters Kluwer India Pvt. Ltd Springer Nature B.V SpringerOpen |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objectives
To evaluate urinary tumor necrosis factor-like weak inducer of apoptosis (uTWEAK)
levels as well as renal fibroblast growth factor-inducible molecule 14 (Fn14) expression
by immunohistochemistry in patients with systemic lupus erythematosus (SLE) to
assess the possible role of TWEAK level as an indicator of lupus nephritis (LN) and
its relation to disease activity as well as pathological LN classification.
Patients and methods
Urinary levels of TWEAK using enzyme-linked immunosorbent assay and chemical
and immunological markers of SLE were measured in 30 patients with SLE and 15
age-matched and sex-matched apparently healthy controls. Patients with SLE were
divided into two subgroups: 15 patients with LN and 15 without LN. Disease activity
was assessed using systemic lupus erythematosus disease activity index SLE
disease activity index (SLEDAI). Fn14 was examined in renal biopsies from LN
group by immunohistochemistry.
Results
A significantly higher uTWEAK level was found in patients having SLE with LN
compared with those without LN and controls (F=149.2, P<0.001). uTWEAK had a
highly significant positive correlation with proteinuria (r=0.755, P<0.001) and a
significant positive correlation with tSLEDAI and rSLEDAI (r=0.217, P<0.037 and
r=0.476, P<0.024, respectively). uTWEAK had a significant negative correlation
with anti-dsDNA titer, C3, and C4 (r=−0.579, P<0.008; r=−0.456, P<0.011; and
r=−0.552, P<0.002, respectively). Fn14 expression was detected in mesangial and
tubular cells, mainly proximal tubular cells, in patients with LN.
Conclusion
uTWEAK is a specific and sensitive biomarker for detection of active LN. |
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| ISSN: | 1110-161X 2090-3235 |
| DOI: | 10.4103/err.err_14_18 |