Search Results - "Abaza, M. S. I."

Synergistic induction of apoptosis and chemosensitization of human colorectal cancer cells by histone deacetylase inhibitor, scriptaid, and proteasome inhibitors: potential mechanisms of action by Abaza, M. S. I., Bahman, A. M., Al-Attiyah, R. J., Kollamparambil, A. M.

“…Histone deacetylase inhibitors (HDACIs) exhibit modest results as single agents in preclinical and clinical studies against solid tumors; they often fall short…”
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In vitro inhibition of human malignant brain tumour cell line proliferation by anti-urokinase-type plasminogen activator monoclonal antibodies by ABAZA, M.-S. I, SHABAN, F. A, NARAYAN, R. K, ZOUHAIR ATASSI, M

“…A brain tumour-associated marker, urokinase (UK), was investigated using rabbit anti-UK polyclonal and murine anti-UK monoclonal antibodies, which were…”
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Augmentation of the anticancer effects of proteasome inhibitors by combination with sodium butyrate in human colorectal cancer cells by ABAZA, M.S.I

“…The ubiquitin-proteasome pathway plays a critical role in the degradation of cellular proteins and cell cycle control. As such, dysregulating the degradation…”
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Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 94-100 (antigenic site 3) of myoglobin by Abaza, M S, Atassi, M Z

“…Amino acid substitutions outside protein antigenic sites are very frequently assumed to exert no effect on binding to antiprotein antibodies, especially if…”
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Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 113-120 (antigenic site 4) of myoglobin by Abaza, M S, Atassi, M Z

“…Immunochemical cross-reactivity of protein variants has been very frequently used to map protein antigenic sites. The approach is based on the assumption that…”
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Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 145-151 (antigenic site 5) of myoglobin by Abaza, M S, Atassi, M Z

“…Monoclonal antibodies of predetermined specificity were prepared by immunization with a free (i.e., without coupling to any protein carrier) synthetic peptide…”
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In vitro Efficacy of Anti‐glial Fibrillary Acidic Protein Monoclonal Antibodies against Human Malignant Glioma Cell Lines by Abaza, Mohamed‐Salah I., Narayan, Raj K., Atassi, M. Z.

“…Our studies have confirmed the presence of large concentrations of various intermediate filament proteins (IFPs) in glioma tissue compared to normal brain…”
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Antisense oligodeoxynucleotide directed against c-myb has anticancer activity and potentiates the antiproliferative effect of conventional anticancer drugs acting by different mechanisms in human colorectal cancer cells by Abaza, Mohamed-Salah I, Al-Attiyah, Rajaa J, Al-Saffar, Amal M, Al-Sawan, Shorooq M, Moussa, Naguib M

“…The C-MYB proto-oncogene encodes a DNA-binding protein with transactivation properties that plays an important regulatory role in cell proliferation and…”
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Anti-urokinase-type plasminogen activator monoclonal antibodies inhibit the proliferation of human breast cancer cell lines in vitro by Abaza, M S, Narayan, R K, Atassi, M Z

“…The levels of several tumor-associated proteases, including plasminogen activators (PA), are elevated in many malignant tumors compared to their benign tumor…”
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Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 56-62 (antigenic site 2) of myoglobin by Abaza, M S, Atassi, M Z

“…This work was carried out in order to study the effects of substitutions outside antigenic site 2 of sperm whale myoglobin (SpMb) on the reactivity of protein…”
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Effects of amino acid substitutions outside an antigenic site on protein binding to monoclonal antibodies of predetermined specificity obtained by peptide immunization: demonstration with region 15-22 (antigenic site 1) of myoglobin by Abaza, M S, Young, C R, Atassi, M Z

“…Monoclonal antibodies (mAbs) of predetermined specificity were prepared by immunizing with a free (i.e., not conjugated to any carrier) synthetic peptide…”
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