Search Results - "Abay, Efrem"

Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues by Wilhelm, Anke, Kendrekar, Pravin, Noreljaleel, Anwar E. M, Abay, Efrem T, Bonnet, Susan L, Wiesner, Lubbe, de Kock, Carmen, Swart, Kenneth J, van der Westhuizen, Jan Hendrik

“…A series of readily synthesized and inexpensive aminoalkylated chalcones and diarylpropane analogues (1–55) were synthesized and tested against…”
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Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products by Calitz, Carlemi, Gouws, Chrisna, Viljoen, Joe, Steenekamp, Jan, Wiesner, Lubbe, Abay, Efrem, Hamman, Josias

“…Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug…”
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The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice by Abay, Efrem T, van der Westhuizen, Jan H, Swart, Kenneth J, Gibhard, Liezl, Tukulula, Matshawandile, Chibale, Kelly, Wiesner, Lubbe

“…Malaria is one of the most lethal and life-threatening killer infectious diseases in the world, and account for the deaths of more than half a million people…”
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Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model by Abay, Efrem T, van der Westuizen, Jan H, Swart, Kenneth J, Gibhard, Liezl, Lawrence, Nina, Dambuza, Ntokozo, Wilhelm, Anke, Pravin, Kendrekar, Wiesner, Lubbe

“…Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the…”
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Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies by Wallis, Lonette, Malan, Maides, Gouws, Chrisna, Steyn, Dewald, Ellis, Suria, Abay, Efrem, Wiesner, Lubbe, Otto, Daniel P, Hamman, Josias

“…Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed…”
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Synthesis and in Vitro and in Vivo Pharmacological Evaluation of New 4‑Aminoquinoline-Based Compounds by Tukulula, Matshawandile, Njoroge, Mathew, Abay, Efrem T, Mugumbate, Grace C, Wiesner, Lubbe, Taylor, Dale, Gibhard, Liezl, Norman, Jennifer, Swart, Kenneth J, Gut, Jiri, Rosenthal, Philip J, Barteau, Samuel, Streckfuss, Judith, Kameni-Tcheudji, Jacques, Chibale, Kelly

“…A new class of 4-aminoquinolines was synthesized and evaluated in vitro for antiplasmodial activity against both the chloroquine-sensitive (3D7) and -resistant…”
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UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria by Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly

“…The 2-aminopyridine MMV048 was the first drug candidate inhibiting phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical…”
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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis by Khonde, Lutete Peguy, Müller, Rudolf, Boyle, Grant A, Reddy, Virsinha, Nchinda, Aloysius T, Eyermann, Charles J, Fienberg, Stephen, Singh, Vinayak, Myrick, Alissa, Abay, Efrem, Njoroge, Mathew, Lawrence, Nina, Su, Qin, Myers, Timothy G, Boshoff, Helena I. M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul D, Massoudi, Lisa M, Robertson, Gregory T, Lenaerts, Anne J, Basarab, Gregory S, Ghorpade, Sandeep R, Chibale, Kelly

“…Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media…”
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Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria by Gibhard, Liezl, Njoroge, Mathew, Paquet, Tanya, Brunschwig, Christel, Taylor, Dale, Lawrence, Nina, Abay, Efrem, Wittlin, Sergio, Wiesner, Lubbe, Street, Leslie J, Chibale, Kelly, Basarab, Gregory S

“…The antimalarial efficacies of two phosphatidylinositol 4-kinase (PI4K) inhibitors, a 3,5-diaryl-2-aminopyrazine sulfoxide and its corresponding sulfone…”
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In Vitro and In Vivo Pharmacokinetics of Aminoalkylated Diarylpropanes NP085 and NP102 by Gibhard, Liezl, Pravin, Kendrekar, Abay, Efrem, Wilhelm, Anke, Swart, Kenneth, Lawrence, Nina, Khoury, Rosal, van der Westhuizen, Jan, Smith, Peter, Wiesner, Lubbe

“…Malaria remains a great burden on humanity. Although significant advances have been made in the prevention and treatment of malaria, malaria control is now…”
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Novel Antitubercular 6‑Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target Identification Studies by Wilson, Colin R, Gessner, Richard K, Moosa, Atica, Seldon, Ronnett, Warner, Digby F, Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B, Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J, Ghorpade, Sandeep R, Chibale, Kelly

“…A BioFocus DPI SoftFocus library of ∼35 000 compounds was screened against Mycobacterium tuberculosis (Mtb) in order to identify novel hits with antitubercular…”
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Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria by Nchinda, Aloysius T, Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Wicht, Kathryn J, Brunschwig, Christel, Njoroge, Mathew, Abay, Efrem, Taylor, Dale, Lawrence, Nina, Wittlin, Sergio, Jiménez-Díaz, María-Belén, Santos Martínez, María, Ferrer, Santiago, Angulo-Barturen, Iñigo, Lafuente-Monasterio, Maria Jose, Duffy, James, Burrows, Jeremy, Street, Leslie J, Chibale, Kelly

“…Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the…”
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Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria" by Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S, Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Nchinda, Aloysius T, de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J, Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L, Charman, Susan A, Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L, van der Watt, Mariëtte E, Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C, Solapure, Suresh M, Burke, John E, McPhail, Jacob A, Vanaerschot, Manu, Fidock, David A, Fish, Paul V, Siegl, Peter, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Silue, Kigbafori D, Street, Leslie J, Chibale, Kelly

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