Search Results - "Abastado, Jean‐Pierre"

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor by Toh, Benjamin, Wang, Xiaojie, Keeble, Jo, Sim, Wen Jing, Khoo, Karen, Wong, Wing-Cheong, Kato, Masashi, Prevost-Blondel, Armelle, Thiery, Jean-Paul, Abastado, Jean-Pierre

“…In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of…”
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Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma by Eyles, Jo, Puaux, Anne-Laure, Wang, Xiaojie, Toh, Benjamin, Prakash, Celine, Hong, Michelle, Tan, Tze Guan, Zheng, Lin, Ong, Lai Chun, Jin, Yi, Kato, Masashi, Prévost-Blondel, Armelle, Chow, Pierce, Yang, Henry, Abastado, Jean-Pierre

“…Although metastasis is the leading cause of cancer-related death, it is not clear why some patients with localized cancer develop metastatic disease after…”
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Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy by Chew, Valerie, Toh, Han Chong, Abastado, Jean-Pierre

“…The tumor microenvironment plays a critical role in cancer development, progression, and control. The molecular and cellular nature of the tumor immune…”
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Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma by Chew, Valerie, Chen, Jinmiao, Lee, Deming, Loh, Evelyn, Lee, Joyce, Lim, Kiat Hon, Weber, Achim, Slankamenac, Ksenija, Poon, Ronnie T P, Yang, Henry, Ooi, London Lucien P J, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Abastado, Jean-Pierre

“…Hepatocellular carcinoma (HCC) is a heterogeneous disease with poor prognosis and limited methods for predicting patient survival. The nature of the immune…”
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Macrophage polarization to a unique phenotype driven by B cells by Wong, Siew-Cheng, Puaux, Anne-Laure, Chittezhath, Manesh, Shalova, Irina, Kajiji, Tasneem S, Wang, Xiaojie, Abastado, Jean-Pierre, Lam, Kong-Peng, Biswas, Subhra K

“…Regulation of adaptive immunity by innate immune cells is widely accepted. Conversely, adaptive immune cells can also regulate cells of the innate immune…”
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Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D by Tan, Kar Wai, Chong, Shu Zhen, Wong, Fiona H.S., Evrard, Maximilien, Tan, Sandra Min-Li, Keeble, Jo, Kemeny, D.M., Ng, Lai Guan, Abastado, Jean-Pierre, Angeli, Véronique

“…Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes…”
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TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression by Ho, Victor, Lim, Tong Seng, Lee, Justin, Steinberg, Jeffrey, Szmyd, Radoslaw, Tham, Muly, Yaligar, Jadegoud, Kaldis, Philipp, Abastado, Jean-Pierre, Chew, Valerie

“…Hepatocellular carcinoma (HCC) is associated with high mortality and the current therapy for advanced HCC, Sorafenib, offers limited survival benefits. Here we…”
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Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma by Penny, Hweixian Leong, Sieow, Je Lin, Gun, Sin Yee, Lau, Mai Chan, Lee, Bernett, Tan, Jasmine, Phua, Cindy, Toh, Florida, Nga, Yvonne, Yeap, Wei Hseun, Janela, Baptiste, Kumar, Dilip, Chen, Hao, Yeong, Joe, Kenkel, Justin A, Pang, Angela, Lim, Diana, Toh, Han Chong, Hon, Tony Lim Kiat, Johnson, Christopher I, Khameneh, Hanif Javanmard, Mortellaro, Alessandra, Engleman, Edgar G, Rotzschke, Olaf, Ginhoux, Florent, Abastado, Jean-Pierre, Chen, Jinmiao, Wong, Siew Cheng

“…Inflammation in the tumor microenvironment has been shown to promote disease progression in pancreatic ductal adenocarcinoma (PDAC); however, the role of…”
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Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma by Tham, Muly, Khoo, Karen, Yeo, Kim Pin, Kato, Masashi, Prevost-Blondel, Amelle, Angeli, Veronique, Abastado, Jean-Pierre

“…Surgical resection of tumors is often followed by regrowth at the primary site and metastases may emerge rapidly following removal of the primary tumor…”
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Mapping of HPV transcripts in four human cervical lesions using RNAseq suggests quantitative rearrangements during carcinogenic progression by Chen, Jinmiao, Xue, Yuezhen, Poidinger, Michael, Lim, Thimothy, Chew, Sung Hock, Pang, Chai Ling, Abastado, Jean-Pierre, Thierry, Françoise

“…Abstract Two classes of Human papillomaviruses (HPV) infect the anogenital track: high risk viruses that are associated with risk of cervical cancer and low…”
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Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients by CHEW, Valerie, TOW, Charlene, NG, Irene Oi-Lin, NARDIN, Alessandra, ABASTADO, Jean-Pierre, HUANG, Caleb, BARD-CHAPEAU, Emilie, COPELAND, Neal G, JENKINS, Nancy A, WEBER, Achim, HON LIM, Kiat, CHONGTOH, Han, HEIKENWALDER, Mathias

“…Hepatocellular carcinoma (HCC) is a highly aggressive cancer that is linked to chronically dysregulated liver inflammation. However, appropriate immune…”
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Expansion of cortical and medullary sinuses restrains lymph node hypertrophy during prolonged inflammation by Tan, Kar Wai, Yeo, Kim Pin, Wong, Fiona H S, Lim, Hwee Ying, Khoo, Kai Ling, Abastado, Jean-Pierre, Angeli, Véronique

“…During inflammation, accumulation of immune cells in activated lymph nodes (LNs), coupled with a transient shutdown in lymphocyte exit, results in dramatic…”
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Covert Human Immunodeficiency Virus Replication in Dendritic Cells and in DC-SIGN-Expressing Cells Promotes Long-Term Transmission to Lymphocytes by NOBILE, Cinzia, PETIT, Caroline, MORIS, Arnaud, SKRABAL, Katharina, ABASTADO, Jean-Pierre, MAMMANO, Fabrizio, SCHWARTZ, Olivier

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands by Chew, Valerie, Abastado, Jean-Pierre

“…In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that…”
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Dacarbazine Promotes Stromal Remodeling and Lymphocyte Infiltration in Cutaneous Melanoma Lesions by Nardin, Alessandra, Wong, Wing-Cheong, Tow, Charlene, Molina, Thierry Jo, Tissier, Frédérique, Audebourg, Anne, Garcette, Marylene, Caignard, Anne, Avril, Marie-Francoise, Abastado, Jean-Pierre, Prévost-Blondel, Armelle

“…Dacarbazine (DTIC) is the standard first-line drug for advanced stage melanoma, but it induces objective clinical responses in only 15% of patients. This study…”
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In silico modeling of cancer cell dissemination and metastasis by Wai, Lu-En, Narang, Vipin, Gouaillard, Alexandre, Ng, Lai Guan, Abastado, Jean-Pierre

“…Metastasis is the main cause of cancer‐related death. It is surprising then that the exact nature of metastasis—the process by which cancer cells leave the…”
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Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model by Bard-Chapeau, Emilie A, Nguyen, Anh-Tuan, Rust, Alistair G, Sayadi, Ahmed, Lee, Philip, Chua, Belinda Q, New, Lee-Sun, de Jong, Johann, Ward, Jerrold M, Chin, Christopher K Y, Chew, Valerie, Toh, Han Chong, Abastado, Jean-Pierre, Benoukraf, Touati, Soong, Richie, Bard, Frederic A, Dupuy, Adam J, Johnson, Randy L, Radda, George K, Chan, Eric Chun Yong, Wessels, Lodewyk F A, Adams, David J, Jenkins, Nancy A, Copeland, Neal G

“…Neal Copeland and colleagues use a transposon mutagenesis screen to identify drivers of hepatocellular carcinoma in a mouse model of chronic hepatitis B…”
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The Next Challenge in Cancer Immunotherapy: Controlling T-Cell Traffic to the Tumor by ABASTADO, Jean-Pierre

“…One of the steps that limits the efficacy of T-cell-based immunotherapy of cancer is T-cell access to the tumor. We recently showed that several…”
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Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma by Garnelo, Marta, Tan, Alex, Her, Zhisheng, Yeong, Joe, Lim, Chun Jye, Chen, Jinmiao, Lim, Kiat Hon, Weber, Achim, Chow, Pierce, Chung, Alexander, Ooi, London Lucien Pj, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Chen, Qingfeng, Abastado, Jean-Pierre, Chew, Valerie

“…The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However,…”
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Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma by Pin, Yeo Kim, Khoo, Karen, Tham, Muly, Karwai, Tan, Hwee, Thiam Chung, Puaux, Anne-Laure, Phua, Meow Ling Cindy, Kato, Masashi, Angeli, Veronique, Abastado, Jean-Pierre

“…Resection of infiltrated tumor-draining lymph nodes (TDLNs) is a standard practice for the treatment of several cancers including breast cancer and melanoma…”
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