Studies of Antimutagenic Effects of Vitamins A and C in Humans

Studies of Antimutagenic Effects of Vitamins A and C in Humans

We studied antimutagenic effects of vitamins A and C (in recommended daily doses for 30 days) and their effects on the kinetics of human buccal epitheliocytes. Buccal swab specimens were collected in 29 students before and after vitamin course. The cytogenetic parameters (cells with micronuclei and...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 154; no. 5; pp. 649 - 653
Main Authors: Abasova, O. Yu, Reutova, N. V., Sycheva, L. P., Chernysheva, E. A.
Format: Journal Article
Language:English
Published: Boston Springer US 01-03-2013
Springer
Springer Nature B.V
Subjects:
Antimutagenic Agents - pharmacology
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Ascorbic Acid - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Nucleus - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Female
Humans
Internal Medicine
Laboratory Medicine
Male
Micronucleus Tests
Mouth Mucosa - drug effects
Mouth Mucosa - metabolism
Pathology
Vitamin A - pharmacology
Vitamins
Young Adult
vitamins A and C
micronuclei
antimutagens
buccal epitheliocytes
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Summary:We studied antimutagenic effects of vitamins A and C (in recommended daily doses for 30 days) and their effects on the kinetics of human buccal epitheliocytes. Buccal swab specimens were collected in 29 students before and after vitamin course. The cytogenetic parameters (cells with micronuclei and protrusions) and parameters of proliferation (binuclear cells and cells with double nuclei) and nucleus destruction (karyopyknosis, karyorrhexis, karyolysis, etc. ) were analyzed. The levels of cells with micronuclei and total level of cytogenetic disorders decreased by 38% after vitamin course, which confirmed their antimutagenic effect. A slight increase in the percentage of apoptotic cells seemed to reflect more active process of elimination of genetically damaged cells.
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2022-7