Search Results - "Abarzua, Lorena"
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Bulk serum extracellular vesicles from stressed mice show a distinct proteome and induce behavioral and molecular changes in naive mice
Published in PloS one (15-08-2024)“…Chronic stress can trigger several pathologies including mood disorders for which no clear diagnostic molecular markers have been established yet. Attractive…”
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2
The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis
Published in Autophagy (01-11-2024)“…Mesenchymal stem cells (MSCs) are used in cell therapy; nonetheless, their application is limited by their poor survival after transplantation in a…”
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Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Published in Biological research (28-09-2024)“…Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These…”
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4
Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light
Published in PloS one (13-08-2012)“…Surprisingly, in our modern 24/7 society, there is scant information on the impact of developmental chronodisruption like the one experienced by shift worker…”
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Gestational chronodisruption impairs hippocampal expression of NMDA receptor subunits Grin1b/Grin3a and spatial memory in the adult offspring
Published in PloS one (24-03-2014)“…Epidemiological and experimental evidence correlates adverse intrauterine conditions with the onset of disease later in life. For a fetus to achieve a…”
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Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
Published in Oncotarget (28-08-2015)“…The evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in…”
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Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity
Published in Cells (Basel, Switzerland) (10-04-2020)“…In the last few decades, it has been established that astrocytes play key roles in the regulation of neuronal morphology. However, the contribution of…”
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Rhythmic Expression of Functional MT1 Melatonin Receptors in the Rat Adrenal Gland
Published in Endocrinology (Philadelphia) (01-03-2008)“…We previously demonstrated that melatonin is involved in the regulation of adrenal glucocorticoid production in diurnal primates through activation of MT1…”
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Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex
Published in Frontiers in pharmacology (17-07-2019)“…Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat mood and anxiety disorders. Chronic treatment with this antidepressant drug is…”
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10
Abstract 5516: Regulation of TFPI-2 in the progression of ovarian cancer
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Ovarian cancer metastasis occurs when malignant cells migrate from the primary tumor into the ascitic fluid and form a secondary tumor in the peritoneal…”
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Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease
Published in Cells (Basel, Switzerland) (07-06-2022)“…Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by…”
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Abstract 3730: 2-Methoxyestradiol induces differentiation of epithelial ovarian cancer-initiating cells sensitizing them to chemotherapy
Published in Cancer research (Chicago, Ill.) (15-04-2013)“…Ovarian cancer is the most deadly gynecological malignancy. Its lethality is mainly due to late diagnosis and acquisition of resistance to available therapies…”
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13
Circadian rhythms in the fetus
Published in Molecular and cellular endocrinology (05-02-2012)“…► The information reviewed here suggests that the fetal circadian system is organized differently from that of the adult. ►Fetal circadian clocks develop as…”
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Abstract B61: Leptin induces a pro-inflammatory macrophage-cancer cell reinforcement loop that favors high-grade serous ovarian cancer progression among overweight/obese women
Published in Clinical cancer research (15-01-2016)“…Introduction: High-grade serous ovarian cancer remains as the most lethal gynecologic cancer. Despite achieving optimal debunking using ultra-radical surgery…”
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Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption
Published in BioMed research international (01-01-2018)“…In the capuchin monkey (Cebus apella), a new-world nonhuman primate, maternal exposure to constant light during last third of gestation induces precocious…”
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Impact of gestational chronodisruption on fetal cardiac genomics
Published in Journal of molecular and cellular cardiology (01-01-2014)“…Abstract We recently reported that gestational chronodisruption induces fetal growth restriction and marked effects on fetal adrenal physiology. Here,…”
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Abstract 2395: Leptin induces an IL-6 mediated interaction between macrophages and ovarian cancer cells that prompted invasiveness and migration
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Introduction: The current knowledge in ovarian epithelial carcinogenesis grants a major role for chronic inflammation in driving the multiple steps in the…”
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Maternal prenatal stress modifies the cargo of circulating small extracellular vesicles and their biodistribution to the placenta and fetus
Published in Placenta (Eastbourne) (01-08-2024)Get full text
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