Search Results - "Abaitua, Fernando"

Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals by Wesolowska-Andersen, Agata, Zhuo Yu, Grace, Nylander, Vibe, Abaitua, Fernando, Thurner, Matthias, Torres, Jason M, Mahajan, Anubha, Gloyn, Anna L, McCarthy, Mark I

“…Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a…”
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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development by Lau, Hwee Hui, Krentz, Nicole A. J., Abaitua, Fernando, Perez-Alcantara, Marta, Chan, Jun-Wei, Ajeian, Jila, Ghosh, Soumita, Lee, Yunkyeong, Yang, Jing, Thaman, Swaraj, Champon, Benoite, Sun, Han, Jha, Alokkumar, Hoon, Shawn, Tan, Nguan Soon, Gardner, Daphne Su-Lyn, Kao, Shih Ling, Tai, E. Shyong, Gloyn, Anna L., Teo, Adrian Kee Keong

“…The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In…”
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Polarized Cell Migration during Cell-to-Cell Transmission of Herpes Simplex Virus in Human Skin Keratinocytes by Abaitua, Fernando, Zia, F. Rabiya, Hollinshead, Michael, O'Hare, Peter

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Differing Roles of Inner Tegument Proteins pUL36 and pUL37 during Entry of Herpes Simplex Virus Type 1 by ROBERTS, Ashley P. E, ABAITUA, Fernando, O'HARE, Peter, MCNAB, David, RIXON, Frazer J, PASDELOUP, David

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Activation mechanism of a noncanonical RNA-dependent RNA polymerase by Garriga, Damià, Navarro, Aitor, Querol-Audí, Jordi, Abaitua, Fernando, Rodríguez, José F, Verdaguer, Núria

“…Two lineages of viral RNA-dependent RNA polymerases (RDRPs) differing in the organization (canonical vs. noncanonical) of the palm subdomain have been…”
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A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function by Grotz, Antje K., Abaitua, Fernando, Navarro-Guerrero, Elena, Hastoy, Benoit, Ebner, Daniel, Gloyn, Anna L.

“…Type 2 diabetes (T2D) is a global pandemic with a strong genetic component, but most causal genes influencing the disease risk remain unknown. It is clear,…”
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Host-range restriction of vaccinia virus E3L deletion mutant can be overcome in vitro, but not in vivo, by expression of the influenza virus NS1 protein by Guerra, Susana, Abaitua, Fernando, Martínez-Sobrido, Luis, Esteban, Mariano, García-Sastre, Adolfo, Rodríguez, Dolores

“…During the last decades, research focused on vaccinia virus (VACV) pathogenesis has been intensified prompted by its potential beneficial application as a…”
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The 2.6-Angstrom Structure of Infectious Bursal Disease Virus-Derived T=1 Particles Reveals New Stabilizing Elements of the Virus Capsid by GARRIGA, Damia, QUEROL-AUDI, Jordi, ABAITUA, Fernando, SAUGAR, Irene, POUS, Joan, VERDAGUER, Nuria, CASTON, José R, RODRIGUEZ, José F

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The Oligomerization Domain of VP3, the Scaffolding Protein of Infectious Bursal Disease Virus, Plays a Critical Role in Capsid Assembly by Maraver, Antonio, Oña, Ana, Abaitua, Fernando, González, Dolores, Clemente, Roberto, Ruiz-Díaz, Jose A, Castón, Jose R, Pazos, Florencio, Rodriguez, Jose F

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Intracellular Interference of Infectious Bursal Disease Virus by GONZALEZ, Dolores, FRANCISCO RODRIGUEZ, Jose, ABAITUA, Fernando

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Loss of ZnT8 function protects against diabetes by enhanced insulin secretion by Dwivedi, Om Prakash, Lehtovirta, Mikko, Hastoy, Benoit, Chandra, Vikash, Krentz, Nicole A. J., Kleiner, Sandra, Jain, Deepak, Richard, Ann-Marie, Abaitua, Fernando, Beer, Nicola L., Grotz, Antje, Prasad, Rashmi B., Hansson, Ola, Ahlqvist, Emma, Krus, Ulrika, Artner, Isabella, Suoranta, Anu, Gomez, Daniel, Baras, Aris, Champon, Benoite, Payne, Anthony J., Moralli, Daniela, Thomsen, Soren K., Kramer, Philipp, Spiliotis, Ioannis, Ramracheya, Reshma, Chabosseau, Pauline, Theodoulou, Andria, Cheung, Rebecca, van de Bunt, Martijn, Flannick, Jason, Trombetta, Maddalena, Bonora, Enzo, Wolheim, Claes B., Sarelin, Leena, Bonadonna, Riccardo C., Rorsman, Patrik, Davies, Benjamin, Brosnan, Julia, McCarthy, Mark I., Otonkoski, Timo, Lagerstedt, Jens O., Rutter, Guy A., Gromada, Jesper, Gloyn, Anna L., Tuomi, Tiinamaija, Groop, Leif

“…A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2…”
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Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM by Przystal, Justyna Magdalena, Hajji, Nabil, Khozoie, Combiz, Renziehausen, Alexander, Zeng, Qingyu, Abaitua, Fernando, Hajitou, Amin, Suwan, Keittisak, Want, Elizabeth, Bomalaski, John, Szlosarek, Peter, O’Neill, Kevin, Crook, Tim, Syed, Nelofer

“…Glioblastoma multiforme (GBM) remains a cancer with a poor prognosis and few effective therapeutic options. Successful medical management of GBM is limited by…”
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Abstract LB-011: Arginine deprivation using ADI-PEG20 leads to regression of an ASS1-ve intracranial GBM tumor in mice and potentiates gamma irradiation of ASS1+ve GBM in vitro by Abaitua, Fernando, Przystal, Justyna, Hajitou, Amin, Syed, Nelofer

“…Abstract Patients with Gliobastoma Multiforme (GBM) have an extremely poor overall survival rate. Novel molecular targeted therapies have failed to provide…”
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression by Mattis, Katia K., Krentz, Nicole A. J., Metzendorf, Christoph, Abaitua, Fernando, Spigelman, Aliya F., Sun, Han, Ikle, Jennifer M., Thaman, Swaraj, Rottner, Antje K., Bautista, Austin, Mazzaferro, Eugenia, Perez-Alcantara, Marta, Manning Fox, Jocelyn E., Torres, Jason M., Wesolowska-Andersen, Agata, Yu, Grace Z., Mahajan, Anubha, Larsson, Anders, MacDonald, Patrick E., Davies, Benjamin, den Hoed, Marcel, Gloyn, Anna L.

“…Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related…”
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Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets by Barbosa, Sónia, Carreira, Suzanne, Bailey, Daniel, Abaitua, Fernando, O'Hare, Peter

“…CREB‑H, an endoplasmic reticulum-anchored transcription factor, plays a key role in regulating secretion and in metabolic and inflammatory pathways, but how…”
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249-LB: PAX4 Loss of Function Alters Human Endocrine Cell Development and Influences Diabetes Risk by KRENTZ, NICOLE, HUI LAU, HWEE, ABAITUA, FERNANDO, PEREZ-ALCANTARA, MARTA, WEI CHAN, JUN, AJEIAN, JILA N., CHAMPON, BENOITE, SUN, HAN, JHA, ALOKKUMAR, HOON, SHAWN, GARDNER, DAPHNE, LING KAO, SHIH, SHYONG TAI, E., GLOYN, ANNA L., TEO, ADRIAN

“…In an effort to identify disease-causing mechanisms, numerous genome-wide studies across different ancestries have discovered genetic variants influencing type…”
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309-OR: Deep Learning Model of Pancreatic Islet Epigenome Refines Association Signals at Type 2 Diabetes Susceptibility Loci by WESOLOWSKA-ANDERSEN, AGATA, THURNER, MATTHIAS, MAHAJAN, ANUBHA, ABAITUA, FERNANDO, TORRES, JASON, NYLANDER, VIBE, GLOYN, ANNA L., MCCARTHY, MARK

“…Translation of genome-wide association study findings is hampered by challenges in pinpointing the causal variant and interpretation of the biological…”
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3-LB: The Type 2 Diabetes-Associated Transcription Factor RREB1 Affects Beta-Cell Function and Development by MATTIS, KATIA K., ABAITUA, FERNANDO, GROTZ, ANTJE, WESOLOWSKA-ANDERSEN, AGATA, PEREZ-ALCANTARA, MARTA, MCCARTHY, MARK, MAHAJAN, ANUBHA, DAVIES, BENJAMIN, GLOYN, ANNA L.

“…Genome-wide association studies have identified multiple independent signals for type 2 diabetes risk at the RREB1 locus. Coding variant fine-mapping (D1171N,…”
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In vitro survival and germination of Candida albicans in the presence of nitrogen compounds by Abaitua, Fernando, Rementeria, Aitor, Millan, Rosario San, Eguzkiza, Ainhoa, Rodriguez, Jose Antonio, Ponton, Jose, Sevilla, Maria Jesus

“…Departamento de Inmunología, Microbiología y Parasitología, Universidad del País Vasco, Apartado 644, 48080-Bilbao, Spain Author for correspondence: María…”
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CB-01TARGETING COLLAGEN REGULATION IN GLIOBLASTOMA MULTIFORME by Abaitua, Fernando, Crook, Tim, O'Neill, Kevin, Syed, Nelofer

“…Extracellular matrices (ECM) are quintessential complex structures that provide cells and tissues of functional support for cell adhesion and migration,…”
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