Search Results - "Abad‐Fernandez, Maria"

OMIP‐087: Thirty‐two parameter mass cytometry panel to assess human CD4 and CD8 T cell activation, memory subsets, and helper subsets by Sponaugle, Alexis, Abad‐Fernandez, Maria, Goonetilleke, Nilu

“…We developed a highly reproducible 32‐marker mass cytometry panel able to measure all canonical immune lineages and perform detailed characterization of both…”
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Precision mouse models with expanded tropism for human pathogens by Wahl, Angela, De, Chandrav, Abad Fernandez, Maria, Lenarcic, Erik M., Xu, Yinyan, Cockrell, Adam S., Cleary, Rachel A., Johnson, Claire E., Schramm, Nathaniel J., Rank, Laura M., Newsome, Isabel G., Vincent, Heather A., Sanders, Wes, Aguilera-Sandoval, Christian R., Boone, Allison, Hildebrand, William H., Dayton, Paul A., Baric, Ralph S., Pickles, Raymond J., Braunstein, Miriam, Moorman, Nathaniel J., Goonetilleke, Nilu, Victor Garcia, J.

“…A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells…”
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Trastuzumab deruxtecan in patients with central nervous system involvement from HER2-positive breast cancer: The DEBBRAH trial by Pérez-García, José Manuel, Vaz Batista, Marta, Cortez, Patricia, Ruiz-Borrego, Manuel, Cejalvo, Juan Miguel, de la Haba-Rodriguez, Juan, Garrigós, Laia, Racca, Fabricio, Servitja, Sonia, Blanch, Salvador, Gion, María, Nave, Monica, Fernández-Abad, María, Martinez-Bueno, Alejandro, Llombart-Cussac, Antonio, Sampayo-Cordero, Miguel, Malfettone, Andrea, Cortés, Javier, Braga, Sofía

“…Trastuzumab deruxtecan (T-DXd) has shown durable antitumor activity in pretreated patients with HER2-positive advanced breast cancer (ABC), but its efficacy…”
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Potent Cell-Cycle Inhibition and Upregulation of Immune Response with Abemaciclib and Anastrozole in neoMONARCH, Phase II Neoadjuvant Study in HR + /HER2 - Breast Cancer by Hurvitz, Sara A, Martin, Miguel, Press, Michael F, Chan, David, Fernandez-Abad, María, Petru, Edgar, Rostorfer, Regan, Guarneri, Valentina, Huang, Chiun-Sheng, Barriga, Susana, Wijayawardana, Sameera, Brahmachary, Manisha, Ebert, Philip J, Hossain, Anwar, Liu, Jiangang, Abel, Adam, Aggarwal, Amit, Jansen, Valerie M, Slamon, Dennis J

“…neoMONARCH assessed the biological effects of abemaciclib in combination with anastrozole in the neoadjuvant setting. Postmenopausal women with stage I-IIIB HR…”
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Optimal [ 18 F]FDG PET/CT Cutoff for Pathologic Complete Response in HER2-Positive Early Breast Cancer Patients Treated with Neoadjuvant Trastuzumab and Pertuzumab in the PHERGain Trial by Gebhart, Geraldine, Keyaerts, Marleen, Guiot, Thomas, Flamen, Patrick, Ruiz-Borrego, Manuel, Stradella, Agostina, Bermejo, Begoña, Escriva-de-Romani, Santiago, Calvo Martínez, Lourdes, Ribelles, Nuria, Fernandez-Abad, María, Albacar, Cinta, Colleoni, Marco, Garrigos, Laia, Atienza de Frutos, Manuel, Dalenc, Florence, Prat, Aleix, Marmé, Frederik, Schmid, Peter, Kerrou, Khaldoun, Braga, Sofia, Gener, Petra, Sampayo-Cordero, Miguel, Cortés, Javier, Pérez-García, José Manuel, Llombart-Cussac, Antonio

“…The PHERGain trial investigated the potential of metabolic imaging to identify candidates for chemotherapy deescalation in human epidermal growth factor…”
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The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression by Serrano-Villar, Sergio, Gutiérrez, Carolina, Vallejo, Alejandro, Hernández-Novoa, Beatriz, Díaz, Laura, Abad Fernández, María, Madrid, Nadia, Dronda, Fernando, Zamora, Javier, Muñoz-Fernández, María Ángeles, Moreno, Santiago

“…Summary Objectives HIV-infected subjects on antiretroviral therapy often fail to normalize the CD4/CD8 ratio despite CD4 count normalization. We aimed to…”
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Olaparib plus trastuzumab in HER2-positive advanced breast cancer patients with germline BRCA1/2 mutations: The OPHELIA phase 2 study by Alés-Martínez, José Enrique, Balmaña, Judith, Sánchez-Rovira, Pedro, Salvador Bofill, Francisco Javier, García Sáenz, Jose Ángel, Pimentel, Isabel, Morales, Serafín, Fernández-Abad, María, Lahuerta Martínez, Ainhara, Ferrer, Neus, Zamora, Pilar, Bermejo, Begoña, Díaz-Redondo, Tamara, López-Ceballos, María Helena, Galán, María, Pérez-Escuredo, Jhudit, Calabuig, Laura, Sampayo, Miguel, Pérez-Garcia, José Manuel, Cortés, Javier, Llombart-Cussac, Antonio

“…To evaluate the efficacy and safety of the combination of olaparib plus trastuzumab in patients with HER2-positive advanced breast cancer (ABC) and germinal…”
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Corrigendum: Reliable estimation of CD8 T cell inhibition of in vitro HIV-1 replication by Xu, Yinyan, Weideman, Ann Marie, Abad-Fernandez, Maria, Mollan, Katie R, Kallon, Sallay, Samir, Shahryar, Warren, Joanna A, Clutton, Genevieve, Roan, Nadia R, Adimora, Adaora A, Archin, Nancie, Kuruc, JoAnn, Gay, Cynthia, Hudgens, Michael G, Goonetilleke, Nilu

“…[This corrects the article DOI: 10.3389/fimmu.2021.666991.]…”
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Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication by Xu, Yinyan, Weideman, Ann Marie, Abad-Fernandez, Maria, Mollan, Katie R, Kallon, Sallay, Samir, Shahryar, Warren, Joanna A, Clutton, Genevieve, Roan, Nadia R, Adimora, Adaora A, Archin, Nancie, Kuruc, JoAnn, Gay, Cindy, Hudgens, Michael G, Goonetilleke, Nilu

“…The HIV-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is increasingly used for clinical testing…”
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HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy by Xu, Yinyan, Trumble, Ilana M., Warren, Joanna A., Clutton, Genevieve, Abad-Fernandez, Maria, Kirchnerr, Jennifer, Adimora, Adaora A., Deeks, Steven G., Margolis, David M., Kuruc, JoAnn D., Gay, Cynthia L., Archin, Nancie M., Mollan, Katie R., Hudgens, Michael, Goonetilleke, Nilu

“…HIV infection induces a robust T cell response that is sustained by high viremia, but falls following the onset of antiretroviral therapy (ART). Relatively…”
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Molecular effects of lapatinib in patients with HER2 positive ductal carcinoma in situ by Estévez, Laura G, Suarez-Gauthier, Ana, García, Elena, Miró, Cristina, Calvo, Isabel, Fernández-Abad, María, Herrero, Mercedes, Marcos, Manuel, Márquez, Cristina, Lopez Ríos, Fernando, Perea, Sofía, Hidalgo, Manuel

“…Human epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly…”
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CD8 T Cell Virus Inhibition Assay Protocol by Xu, Yinyan, Weideman, Ann Marie, Abad-Fernandez, Maria, Mollan, Katie R, Kallon, Sallay, Samir, Shahryar, Warren, Joanna A, Clutton, Genevieve, Roan, Nadia, Adimora, Adaora A, Archin, Nancie, Kuruc, JoAnn, Gay, Cindy, Hudgens, Michael G, Goonetilleke, Nilu

“…The human immunodeficiency virus (HIV)-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is…”
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Concluding Remarks for Special Issue HTLV-HIV Co-Infections by Vallejo, Alejandro, Abad-Fernández, María

“…During the early 1980s, the first 3 human retroviruses were identified: human T-lymphotropic virus 1 and 2 (HTLV-1 and HTLV-2) and human immunodeficiency virus…”
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Human cytomegalovirus-vectored vaccines against HIV by Abad-Fernandez, Maria, Goonetilleke, Nilu

“…PURPOSE OF REVIEWCMV-vectored vaccines expressing SIV antigens have mediated unprecedented levels of virus control following SIV challenge in rhesus macaques…”
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Brief Report: Toll-like Receptor 9-1635A/G Polymorphism Is Associated With HIV-1 Rebound After Four Weeks of Interruption of Antiretroviral Therapy by Vallejo, Alejandro, Molina-Pinelo, Sonia, de Felipe, Beatriz, Abad-Fernández, María, González-Escribano, María Francisca, Leal, Manuel, Soriano-Sarabia, Natalia

“…OBJECTIVES:This study aims to analyze the association of the presence of common polymorphisms [single nucleotide polymorphisms (SNPs)] on Toll-like receptors…”
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Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo by Garrido, Carolina, Abad-Fernandez, Maria, Tuyishime, Marina, Pollara, Justin J, Ferrari, Guido, Soriano-Sarabia, Natalia, Margolis, David M

“…Current efforts toward human immunodeficiency virus (HIV) eradication include approaches to augment immune recognition and elimination of persistently infected…”
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The effect of intensification with raltegravir on the HIV-1 reservoir of latently infected memory CD4 T cells in suppressed patients by VALLEJO, Alejandro, GUTIERREZ, Carolina, MUNOZ-FERNANDEZ, María A, MORENO, Santiago, HERNANDEZ-NOVOA, Beatriz, DIAZ, Laura, MADRID, Nadia, ABAD-FERNANDEZ, María, DRONDA, Fernando, PEREZ-ELIAS, Maria J, ZAMORA, Javier, MUNOZ, Eduardo

“…The stability of the reservoir of latently infected memory CD4 T-cells may be associated with continuous replenishment from residual HIV-1, not completely…”
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Maintained complete response to talazoparib in a BRCA-2 mutated metastatic luminal breast cancer: case report and review of literature by Albarrán, Víctor, Chamorro, Jesús, Pozas, Javier, San Román, María, Rosero, Diana Isabel, Saavedra, Cristina, Gion, María, Cortés, Alfonso, Escalera, Elena, Guerra, Eva, López Miranda, Elena, Fernández Abad, María, Martínez Jañez, Noelia

“…PARP inhibitors are progressively becoming a part of our therapeutic arsenal against BRCA-defective tumors, because of their capacity to induce synthetic…”
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HTLV-2 Enhances CD8 + T Cell-Mediated HIV-1 Inhibition and Reduces HIV-1 Integrated Proviral Load in People Living with HIV-1 by Abad-Fernández, María, Hernández-Walias, Francisco J, Ruiz de León, María J, Vivancos, María J, Pérez-Elías, María J, Moreno, Ana, Casado, José L, Quereda, Carmen, Dronda, Fernando, Moreno, Santiago, Vallejo, Alejandro

“…People living with HIV-1 and HTLV-2 concomitantly show slower CD4 T cell depletion and AIDS progression, more frequency of the natural control of HIV-1, and…”
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Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART - the M&M Study by Xu, Yinyan, Samir, shahryat, Weideman, Ann Marie K., Kallon, Sallay, Conrad, Shayla, Shaw, Fiona, Warren, Joanna, Fernandez, Maria Abad, Fox, Lawrence, Margolis, David M., Hudgens, Michael G., Hanke, Tomas, Kuruc, JoAnn, Gay, Cindy, Goonetilleke, Nilu

“…CD8+ T cell immunity is essential to the control of HIV viremia. We examined the safety and immunogenicity of MVA-vectored vaccines expressing highly conserved…”
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